Associate Professor Chris Ormandy
Principal Research Fellow; Group Leader, Cancer Research Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Department of Medicine, The University of New South Wales
Email: c.ormandy 'at' garvan.org.au
Research Group: Mammary Development
Education
1992 PhD ,The University of New South Wales
1984 BSc (Hons), University of Sydney
Publications
Ormandy CJ, Camus A, Barra J, Damotte D, Lucas B, Buteau H, Edery M, Brousse N, Babinet C, Binart N and Kelly PA (1997). Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11: 167-78.Ormandy CJ, Lee CS, Ormandy HF, Fantl V, Shine J, Peters G and Sutherland RL (1998). Amplification, expression, and steroid regulation of the preprogalanin gene in human breast cancer. Cancer Res 58: 1353-7.
Wynick D, Small CJ, Bacon A, Holmes FE, Norman M, Ormandy CJ, Kilic E, Kerr NC, Ghatei M, Talamantes F, Bloom SR and Pachnis V (1998). Galanin regulates prolactin release and lactotroph proliferation. Proc Natl Acad Sci U S A 95: 12671-6.
Brisken C, Kaur S, Chavarria TE, Binart N, Sutherland RL, Weinberg RA, Kelly PA and Ormandy CJ (1999). Prolactin controls mammary gland development via direct and indirect mechanisms. Dev Biol 210: 96-106.
Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ and Visvader J (2001). SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 15: 1631-6.
Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, Ormandy CJ and Herzog H (2002). Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 16: 1077-88.
Zhou J, Chehab R, Tkalcevic J, Naylor MJ, Harris J, Wilson TJ, Tsao S, Tellis I, Zavarsek S, Xu D, Lapinskas EJ, Visvader J, Lindeman GJ, Thomas R, Ormandy CJ, Hertzog PJ, Kola I and Pritchard MA (2005). Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. Embo J 24: 635-44.
Harris J Stanford PM, Sutherland K, Oakes SR, Naylor MJ, Robertson FG, Blazek KD, Kazlauskas M, Hilton HN, Wittlin S, Alexander WS, Lindeman GJ, Visvader JE and Ormandy CJ. (2006) Socs2 and Elf5 mediate prolactin-induced mammary gland development. Mol Endocrinology 201177-1187.
Oakes SR, Robertson FG, Kench JG, Gardiner-Garden M, Wand MP, Green JE and Ormandy, CJ. (2007) Loss of mammary epithelial prolactin receptor delays tumor formation by reducing cell proliferation in low-grade preinvasive lesions. Oncogene 26: 543-553.
Oakes SR, Naylor, MJ, Asselin-Labat Blazek KD, Gardiner-Garden M, Hilton H, Kazlauskas K, Pritchard M, Chodosh L, Pfeffer P, Lindeman G, Visvader J and Ormandy CJ. The ets transcription factor Elf5 specifies mammary alveolar cell fate. (2008) Genes and Development 22:581-586
