Associate Professor Greg Cooney
Principal Research Fellow; Group Leader and Deputy Director, Diabetes & Obesity Research Program, Garvan Institute of Medical Research; NHMRC Senior Research Fellow; Conjoint Associate Professor, Faculty of Medicine, The University of New South Wales
Email: g.cooney 'at' garvan.org.au
Research Group: Cooney
1980 PhD (Biochemistry) University of Sydney
1976 BSc (Hons 1) University of Sydney
Roslyn Flora Goulston Prize for Biochemistry.
Eleanor Sophia Wood Travelling Fellowship
NHMRC Senior Research Fellowship
Overexpression of the orphan receptor Nur77 alters glucose metabolism in rat muscle cells and rat muscle in vivo. Kanzleiter T, Preston E, Wilks D, Ho B, Benrick A, Reznick J, Heilbronn LK, Turner N, Cooney GJ. Diabetologia. 2010 53:1174-83
Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle. Quinlan KG, Seto JT, Turner N, Vandebrouck A, Floetenmeyer M, Macarthur DG, Raftery JM, Lek M, Yang N, Parton RG, Cooney GJ, North KN. Hum Mol Genet. 2010 19:1335-46
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, Cooney GJ. Cell Metab. 2010 11:70-6
Insulin resistance is a cellular antioxidant defense mechanism. Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Proc Natl Acad Sci U S A. 2009 106:17787-92.
Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids. Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EW, Cooney GJ, Ye JM. Diabetes. 2009 58:2547-54.
Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Holt LJ, Lyons RJ, Ryan AS, Beale SM, Ward A, Cooney GJ, Daly RJ. Mol Endocrinol. 2009 23:1406-14
Regulation of the nuclear hormone receptor nur77 in muscle: influence of exercise-activated pathways in vitro and obesity in vivo. Kanzleiter T, Wilks D, Preston E, Ye J, Frangioudakis G, Cooney GJ. Biochim Biophys Acta. 2009 1792:777-82
Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. Hoy AJ, Brandon AE, Turner N, Watt MJ, Bruce CR, Cooney GJ, Kraegen EW. Am J Physiol Endocrinol Metab. 2009 297:E67-75
Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, Perry M, Bazzani R, Sheardown SA, Hegarty BD, Lyons RJ, Cooney GJ, Daly RJ, Ward A. Mol Cell Biol. 2007 27:5871-86.
Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ. Diabetes. 2007 56:2085-92