Associate Professor Jiming Ye
Senior Research Officer, Group Leader, Diabetes & Obesity Research Program, Garvan Institute of Medical Research; Conjoint Associate Professor, School of Medical Sciences, University of NSW; NHMRC Program Grant Co-Chief Investigator.
Email: j.ye "at" garvan.org.au
Research Group: Ye
Education
1995 PhD (Biochemistry) University of Tasmania, Australia
1985 Master of Medicine (Pathophysiology) Kunming Medical University, China
1982 Bachelor (Medicine) Kunming Medical University, China
Awards
1986 Second Prize for S&T Advances (Novel Therapies for Brain Ischaemia), China.
2005 Visiting Professor, The First Hospital of Hebei Province, China.
2007 Visiting Professor, The Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
Selected Publications
Turner N, Hariharan K, Tid-Ang J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie S, Li JY, Kraegen EW, Cooney GJ & Ye JM. Enhancement of muscle mitochondrial oxidative capacity and preservation of insulin action is lipid species-dependent: Potent tissue-specific effects of medium chain fatty acids. Diabetes [Epub ahead of print]. Aug 31,2009.
Turner N, Li JY, Gosby A, To SWC, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu LH, Li J & Ye JM. Berberine, and its more biologically available derivative dihydroberberine, inhibit mitochondrial respiratory Complex I: a mechanism for the action of berberine to activate AMPK and improve insulin action. Diabetes 57:1414-1418, 2008.
Tan MJ, Ye JM (co-first author), Turner N, Hohnen-Behrens C, Ke CQ, Tang CP, Chen T, Weiss HC, Gesing ER, Rowland A, James DE & Ye Y. Anti-diabetic activities of newly-identified triterpenoids from bitter melon associated with activation of the AMPK pathway. Chem Biol 15:263-273, 2008.
Ye JM, Dzamko N, Hoy AJ, Kemp B & Kraegen EW. Rosiglitazone enhances acute AMPK-mediated muscle and adipose tissue glucose uptake in high fat-fed rats. Diabetes 55: 2797-804, 2006.
Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Keun WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB. Berberine, a natural plant product, activates AMPK with beneficial metabolic effects in diabetic and insulin resistant states. Diabetes 55:2256-64, 2006.
Frangioudakis G, Ye JM & Cooney GJ. Both saturated and n-6 polyunsaturated fat diets reduce phosphorylation of IRS-1 and PKB in muscle during the initial stages of in vivo insulin stimulation. Endocrinology 146:5596-603, 2005.
Cleasby M, Dzamko N, Hergarty B, Cooney GJ, Kraegen EW & Ye JM. Metformin prevents the development of acute lipid-induced insulin resistance in the rats through altered lipids hepatic signalling mechanisms. Diabetes 53:3258-66, 2004.
Ye JM, Dzamko N, Cleasby M, Hergarty B, Cooney GJ & Kraegen EW: Direct demonstration of the "lipid steal" mechanism of action of rosiglitazone in the prevention of lipid-induced insulin resistance in the rats: comparison with metformin. Diabetologia 47: 1306-1313, 2004.
Iglesias MA, Furler SF, Cooney GJ & Kraegen EW & Ye JM. Activation of AMPK with AICAR simultaneously increases glucose and fatty acid uptake in muscle of lipid-induced insulin resistant rats. Diabetes 53: 1649-1654, 2004.
Ye JM, Iglesias MA, Wassermann K, Watson DG, Cooney GJ & Kraegen EW. PPARalpha/gammar agonist ragaglitazar eliminates fatty liver and insulin resistance in high-fat fed rats in the absence of hepatomegaly. Am J Physiol 284: E531-E540, 2003.
Ye JM, Frangioudakis G, Iglesias MA, Furler SM, Ellis B, Dzamko N, Cooney GJ & Kraegen EW. Prior thiazolidinedione treatment preserves insulin sensitivity in normal rats during acute fatty acid elevation: role of the liver. Endocrinology 143:4527-4535, 2002.
Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tom·s E, Ruderman NB, Cooney GJ & Kraegen EW: AICAR administration causes a prolonged enhancement of muscle and liver insulin action high-fat fed rats. Diabetes 51:2886-2894, 2002.
Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ & Kraegen EW. PPARalpha activation lowers muscle lipids and improves insulin sensitivity in high-fat-fed rats: comparison with PPARgamma activation. Diabetes 50:411-417, 2001.
Ye JM & Colquhoun EQ. Changes in functional expression of alpha1-adrenoceptors in hindlimb vascular bed of spontaneously hypertensive rats and their effects on oxygen consumption. J Pharmacol Exp Ther 286: 599-606, 1998.
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