Prof Tuan Nguyen

Lab Head - Genetic Epidemiology of Osteoporosis

Principal Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Professor, School of Public Health and Community Medicine; St Vincent's Clinical School, UNSW Medicine, UNSW Australia; Adjunct Professor, Centre for Health Technologies, University of Technology, Sydney.

Dr. Tuan V. Nguyen is a Principal Research Fellow and Head of the Genetics and Epidemiology Research Lab (Bone Biology Division). He received his PhD in Medicine from the University of New South Wales and a Master’s degree in Statistics from Macquarie University. He has been involved in osteoporosis research for more than 20 years. The primary focus of his research is on the discovery and translation of novel genetic and environmental factors that determine the risk of fracture.

Dr. Nguyen has published more than 200 papers, including 184 original papers, 21 invited reviews and 10 book chapters. Dr. Nguyen’s work has been published in many influential journals, including New England Journal of Medicine, JAMA, Annals of Internal Medicine, British Medical Journal, Lancet, Nature, Nature Genetics, Nature Review Endocrinology, JBMR, JCEM. His total citations amounted to 19,472 (as at 20/2/2014). His career-wise H-index is 65, and his last five-year H index is 45.

One of his achievements is the translation of 20-year research into a prognostic tool called “Garvan Fracture Risk Calculator” for assessing fracture risk for an individual. This model was developed based on the idea of individualised assessment which he had advanced previously. The model has been implemented in a dedicated website (infractureriskcalculator.com).

Dr. Nguyen has contributed to the profession through his services in journal editorial boards and peer review. He has served on the Publication Committee of the American Society for Bone and Mineral Research (2008-2012). Currently, he is on the editorial board of journals such as the Journal of Bone and Mineral Research, Osteoporosis International, and Journal of Clinical Endocrinology and Metabolism, and associate editor of BMC Musculoskel Disorders.  He is a regular reviewer for more than 20 medical and bone journals. He also contributed to grant review for many funding agencies around the world, including NHMRC, Wellcome Trust, NIH, Elan (Germany), etc.  Dr. Nguyen regularly speaks or gives lectures in major osteoporosis conferences. He has also been invited to serve on organising committees of various international conferences.  

Research Interests

Genetics and epidemiology of osteoporosis
Personalised medicine
Development of prognostic models for individualising fracture risk
Bayesian interpretation of clinical studies

Awards and Honours

2008-2013 - NHMRC Senior Research Fellowship
1998 - Garvan Best Thesis Award

Education

1997 - PhD (Medicine), University of New South Wales, Sydney - Australia

Selected Publications

Ho-Pham LT, Nguyen U, Nguyen TV. Association between lean mass, fat mass and bone mineral density: a meta-analysis. J Clin Endocrinol Metab 2014; 99:30-8. 

Yang S, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Association between abdominal obesity and fracture risk: a prospective study. J Clin Endocrinol Metab. 2013;98(6):2478-83. 

Tran B, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility. Clin Endocrinol (Oxf). 2013 Sep 21.

Frost SA, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Excess mortality attributable to hip-fracture: A relative survival analysis. Bone 2013;56(1):23-29.

Chan MY, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Quantitative ultrasound and fracture risk prediction in non-osteoporotic men and women as defined by WHO criteria. Osteoporos Int. 2013;24(3):1015-22.

Bliuc D, Nguyen ND, Nguyen TV, Eisman JA, Center JR. Compound risk of high mortality following osteoporotic fracture and re-fracture in elderly women and men. J Bone Miner Res 2013; Apr 24.

Styrkarsdottir U, Thorleifsson G, Sulem P, Gudbjartsson DF, Sigurdsson A, Jonasdottir A, Jonasdottir A, Oddsson A, Helgason A, Magnusson OT, Walters GB, Frigge ML, Helgadottir HT, Johannsdottir H, Bergsteinsdottir K, Ogmundsdottir MH, Center JR, Nguyen TV, Eisman JA, Christiansen C, Steingrimsson E, Jonasson JG, Tryggvadottir L, Eyjolfsson GI, Theodors A, Jonsson T, Ingvarsson T, Olafsson I, Rafnar T, Kong A, Sigurdsson G, Masson G, Thorsteinsdottir U, Stefansson K. Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits. Nature. 2013;497(7450):517-20.

Nguyen HT, von Schoultz B, Nguyen TV, Dzung DN, Duc PT, Thuy VT, Hirschberg AL. Vitamin D deficiency in northern Vietnam: prevalence, risk factors and associations with bone mineral density. Bone. 2012;51(6):1029-34.

Chan MY, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Absolute fracture-risk prediction by a combination of calcaneal quantitative ultrasound and bone mineral density. Calcif Tissue Int. 2012;90(2):128-36. 

Ho-Pham LT, Vu BQ, Lai TQ, Nguyen ND, Nguyen TV. Vegetarianism, bone loss, fracture and vitamin D: a longitudinal study in Asian vegans and non-vegans. Eur J Clin Nutr. 2012;66(1):75-82.

Tran BN, Nguyen ND, Nguyen VX, Center JR, Eisman JA, Nguyen TV. Genetic profiling and individualized prognosis of fracture. J Bone Miner Res. 2011;26(2):414-9. 

Frost SA, Nguyen ND, Black DA, Eisman JA, Nguyen TV. Risk factors for in-hospital post-hip fracture mortality. Bone. 2011;49(3):553-8.

Center JR, Bliuc D, Nguyen ND, Nguyen TV, Eisman JA. Osteoporosis medication and reduced mortality risk in elderly women and men. J Clin Endocrinol Metab. 2011;96(4):1006-14.

Langsetmo L, Nguyen TV, Nguyen ND, Kovacs CS, Prior JC, Center JR, Morin S, Josse RG, Adachi JD, Hanley DA, Eisman JA; Canadian Multicentre Osteoporosis Study Research Group. Independent external validation of nomograms for predicting risk of low-trauma fracture and hip fracture. CMAJ. 2011;183(2):E107-14

Ho-Pham LT, Nguyen ND, Nguyen TV. Effect of vegetarian diets on bone mineral density: a Bayesian meta-analysis. Am J Clin Nutr. 2009;90(4):943-50.

Frost SA, Nguyen ND, Center JR, Eisman JA, Nguyen TV. Timing of repeat BMD measurements: development of an absolute risk-based prognostic model. J Bone Miner Res. 2009;24(11):1800-7.

Bliuc D, Nguyen ND, Milch VE, Nguyen TV, Eisman JA, Center JR. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA. 2009;301(5):513-21.

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Snorradóttir S, Center JR, Nguyen TV, Alexandersen P, Gulcher JR, Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K. New sequence variants associated with bone mineral density. Nat Genet. 2009;41(1):15-7.

Reviews

Nguyen TV, Eisman JA. Genetic profiling and individualized assessment of fracture risk. Nat Rev Endocrinol 2013;9(3):153-61.

Nguyen TV, Center JR, Eisman JA. Individualized fracture risk assessment: progresses and challenges. Curr Opin Rheumatol 2013;25(4):532-41.

Nguyen TV, Eisman JA. Genetics and the individualized prediction of fracture. Curr Osteoporos Rep 2012;10(3):236-44.

Nguyen TV, Center JR, Eisman JA. Pharmacogenetics of osteoporosis and the prospect of individualized prognosis and individualized therapy. Curr Opin Endocrinol Diabetes Obes. 2008;15(6):481-8.

Prof Tuan Nguyen