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Dr Adam Cole

 

NHMRC Peter Doherty Fellow, Group Leader, Neurosignalling Group, Neuroscience Program, Garvan Institute for Medical Research

Email: a.cole 'at' garvan.org.au
Research Group: Neurosignalling

 
 
Adam’s biochemical career began at the Ludwig Institute for Cancer Research in Melbourne, where he performed proteomic analyses of colorectal cancer for his PhD. This sparked an interest in protein phosphorylation, so he moved to one of the world’s most famous phosphorylation labs, the MRC Protein Phosphorylation Unit at the University of Dundee in Scotland. His first post-doc position was with Sir Philip Cohen, the unit director, where he was introduced to an important enzyme called GSK3. His second post-doc position was with Calum Sutherland, a defector from the unit to the nearby teaching hospital, where he focused on the role of GSK3 in the brain.
 
 
 

In 2010, Adam established the Neurosignalling Group at the Garvan Institute, where he continues his research on GSK3 in the brain and has expanded his program to include two closely-related enzymes called Cdk5 and PCTK2.  This research will lead to a better understanding of signalling pathways that maintain healthy brain function (e.g. cognition, learning and memory).  Importantly, it will inform us about signalling defects that arise during aging and in devastating neurodegenerative diseases like Alzheimer’s disease.

Education

2002 PhD Ludwig Institute for Cancer Research and University of Melbourne
1997 B.Sc.(Hons) Ludwig Institute for Cancer Research and University of Melbourne
1996 B.Sc. LaTrobe University, Melbourne
1996 Dip.Ed. LaTrobe University, Melbourne

Awards and Honours

2007-2011 NHMRC Peter Doherty Fellowship
1997 Dean's Honours List, University of Melbourne

Selected Publications

Clayton EL, Sue N, Smillie KJ, O’Leary T, Bache N, Cheung G, Cole AR, Wyllie DJ, Sutherland C, Robinson PJ and Cousin MA. DynaminI phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles Nat. Neuroscience (accepted, in-press)

Cole, AR  PCTK proteins: the forgotten brain kinases?  Neurosignals 17(4):288-97 (2009)

Cole AR, Soutar MPM, Rembutsu M, VanAalten L, Hastie CJ, McLauchlan H, Peggie MW, Balastik M, Lu KP and Sutherland C.  Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation.  J. Biol. Chem. 283(26):18227-37 (2008)

Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, LaFrancois J, Taylor M, Gunn-Moore F, Verkhratsky A, Oddo S, La Ferla F, Duff K, Giese KP, Dineley KT, Richardson  JC, Yan SD, Hanger DP, Allan SM and Sutherland C.  Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer’s disease progression.  J. Neurochem. 103(3):1132-44 (2007)

Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, Hernandez F, Eickholt BJ, Nikolic M, Sutherland C.  Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo.  J. Biol. Chem. 281:16591-8 (2006)

Cole AR, Knebel A, Morrice NA, Robertson LA, Irving AJ, Connolly CN, Sutherland C.  GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons.  J. Biol. Chem. 279:50176-80 (2004)

Cole AR, Frame S and Cohen P.  Further evidence that the tyrosine phosphorylation of glycogen synthase kinase 3 (GSK3) in mammalian cells is an autophosphorylation event.  Biochem J. 377:249-55 (2004)

Cole AR, Hall NE, Treutlein HR, Eddes JS, Reid GE, Moritz RL and Simpson RJ.  Disulfide bond structure and N-glycosylation sites of the human interleukin-6 receptor extracellular domain.  J. Biol. Chem. 274 (11):7207-7215 (1999)

 

 

Search for all publications by AR Cole

 

 

 
 
 

Areas of Interest

Protein phosphorylation, kinases, brain function, neuronal signalling, neurite outgrowth, synapse formation, neurotransmission, aging, neurodegenerative diseases, Alzheimer’s disease
 
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