Dr Amanda Sainsbury-Salis
Senior Research Fellow; Group leader, Neuroscience Research Program, Garvan Institute of Medical Research; NHMRC Fellow; Conjoint Senior Lecturer, Faculties of Science & Medicine, The University of New South Wales
Email: a.sainsbury-salis 'at' garvan.org.au
Research Group: Eating Disorders
The aim of Amanda’s current research is to find ways to block neuropeptide Y and other mediators of the famine reaction so that more people can attain and maintain a healthy body weight. To read more about the implications of Amanda’s research for people trying to lose weight and keep it off, click here.
Education
1996 PhD, University of Geneva Switzerland
1993 Certificate of Specialization in Medical Biology, University of Geneva Switzerland
1990 Bachelor of Science (Hons) University of Western Australia
Awards
2008 Career Development Award, NHMRC
2004 NSW Young Tall Poppy Award
2002 Young Investigator of the Year, Australiasian Society for the Study of Obesity
2002 Career Development Award, NHMRC and Diabetes Australia Research Trust
2001 Travel Grant, Juvenile Diabetes Research Foundation
1998 Peter Doherty Fellowship, NHMRC
1997 Post-doctoral Fellowship, Milena Carvjal Foundation Switzerland
1995 Travel Grant, European Neuroendocrine Association
1991 Postgraduate Scholarship, Swiss Government
1989 Stansen's Prize, University of Western Australia
Publications
Boey D, Lin S, Enriquez RF, Lee NJ, Slack K, Couzens M, Baldock PA, Herzog H, Sainsbury A. PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides, 2008;42(1):19-30.
Sainsbury A, Lin S, McNamara K, Slack K, Enriquez R, Lee NJ, Boey D, Smythe GA, Schwarzer C, Baldock P, Karl T, Lin EJ, Couzens M, Herzog H. Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice. Mol Endocrinol 2007; 21(7):1722-1735.
Sainsbury A, Bergen HT, Boey D, Bamming D, Cooney GJ, Lin S, Couzens M, Stroth N, Lee NJ, Lindner D, Singewald N, Karl T, Duffy L, Enriquez R, Slack K, Sperk G, Herzog H. Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Diabetes 2006; 55(1):19-26.
Lin EJ, Sainsbury A, Lee NJ, Boey D, Couzens M, Enriquez R, Slack K, Bland R, During MJ, Herzog H. Combined deletion of Y1, Y2, and Y4 receptors prevents hypothalamic neuropeptide Y overexpression-induced hyperinsulinemia despite persistence of hyperphagia and obesity. Endocrinology 2006; 147(11):5094-101.
Wheway J, Mackay CR, Newton RA, Sainsbury A, Boey D, Herzog H, Mackay F. A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J Exp Med 2005; 202(11):1527-38.
Sainsbury A, Baldock PA, Schwarzer C, Ueno N, Enriquez RF, Couzens M, Inui A, Herzog H, Gardiner EM. Synergistic reduction in adiposity and increase in bone mass in Y2/Y4 receptor double knockout mice. Mol Cell Biol 2003; 23:5225-5233.
Sainsbury A, Schwarzer C, Couzens M, Herzog H. Y2 receptor deletion reverses the type 2 diabetic syndrome of ob/ob mice. Diabetes 2002; 51:3420-3427.
Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Fürtinger S, Jenkins A, Cox HM, Sperk G, Hökfelt T, Herzog H. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. P Natl Acad Sci USA 2002; 99:8938-8943.
Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, Ormandy CJ, Herzog H. Y4 receptor knockout rescues fertility in ob/ob mice. Gene Dev 2002; 16:1077-1088.
