Associate Professor Amanda Sainsbury-Salis
Senior Research Fellow; Group leader, Neuroscience Research Program, Garvan Institute of Medical Research; NHMRC Fellow; Conjoint Senior Lecturer, Faculties of Science & Medicine, The University of New South Wales
Email: a.sainsbury-salis 'at' garvan.org.au
Research Group: Eating Disorders
The aim of Amanda’s current research is to find ways to block neuropeptide Y and other mediators of the famine reaction so that more people can attain and maintain a healthy body weight. To read more about the implications of Amanda’s research for people trying to lose weight and keep it off, click here.
Education
1996 PhD, University of Geneva Switzerland
1993 Certificate of Specialization in Medical Biology, University of Geneva Switzerland
1990 Bachelor of Science (Hons) University of Western Australia
Awards
2008 Career Development Award, NHMRC
2004 NSW Young Tall Poppy Award
2002 Young Investigator of the Year, Australiasian Society for the Study of Obesity
2002 Career Development Award, NHMRC and Diabetes Australia Research Trust
2001 Travel Grant, Juvenile Diabetes Research Foundation
1998 Peter Doherty Fellowship, NHMRC
1997 Post-doctoral Fellowship, Milena Carvjal Foundation Switzerland
1995 Travel Grant, European Neuroendocrine Association
1991 Postgraduate Scholarship, Swiss Government
1989 Stansen's Prize, University of Western Australia
Selected Publications
Zhang L, Riepler SJ, Turner N, Enriquez RF, Lee IC, Herzog H, Baldock PA, Sainsbury A: Y2 and Y4 receptor signalling synergistically act on energy expenditure and physical activity. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 2010; 299(6)R1618-28
Shi Y, Lin S, Wong IPL, Baldock PA, Aljanova A, Enriquez RF, Castillo L, Mitchell NF, Ye J, Zhang L, Macia L, Yulyaningsih E, Nguyen AD, Riepler S, Herzog H, Sainsbury A: NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice. PLoS ONE 2010; 29;5(6):e11361
Cox HM, Tough IR, Woolston AM, Zhang L, Nguyen AD, Sainsbury A, Herzog H: Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. Cell Metabolism 2010; 11(6): 532-542
Zhang L, Lee NJ, Nguyen AD, Enriquez RF, Riepler SJ, Stehrer B, Yulyaningsih E, Lin S, Shi YC, Baldock PA, Herzog H, Sainsbury A: Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation. Diabetes, Obesity and Metabolism 2010; 12(7): 591-603
Zhang L, Macia L, Turner N, Enriquez RF, Riepler SJ, Nguyen AD, Lin S, Lee NJ, Shi Y, Yulyaningsih E, Slack K, Baldock PA, Herzog H, Sainsbury A: Peripheral Neuropeptide Y Y1-Receptors Regulate Lipid Oxidation and Fat Accretion. International Journal of Obesity 2010; 34(2): 357-373
Lin S, Shi YC, Yulyaningsih E, Aljanova A, Zhang L, Macia L, Nguyen AD, Lin EJD, During MJ, Herzog H, Sainsbury A: Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS ONE 2009; 4(12): e8488
Lee, NJ, Enriquez RF, Boey D, Lin S, Slack K, Baldock PA, Herzog H, Sainsbury A: Synergistic attenuation of obesity by Y2 and Y4 receptor double knockout in ob/ob mice. Nutrition: The International Journal of Applied and Basic Nutritional Sciences 2008; 24(9): 892-899
Boey D, Lin S, Enriquez RF, Lee NJ, Slack K, Couzens M, Baldock PA, Herzog H, Sainsbury A. PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides, 2008;42(1):19-30.
Sainsbury A, Lin S, McNamara K, Slack K, Enriquez R, Lee NJ, Boey D, Smythe GA, Schwarzer C, Baldock P, Karl T, Lin EJ, Couzens M, Herzog H. Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice. Mol Endocrinol 2007; 21(7):1722-1735.
Wheway J, Mackay CR, Newton RA, Sainsbury A, Boey D, Herzog H, Mackay F. A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J Exp Med 2005; 202(11):1527-38.
Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Fürtinger S, Jenkins A, Cox HM, Sperk G, Hökfelt T, Herzog H. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. P Natl Acad Sci USA 2002; 99:8938-8943.
