Prof Andrew Biankin

Lab Head - Pancreatic Cancer Research

Conjoint/Adjunct Role(s)

Professor, Conjoint Appointee UNSW Australia
Consultant Hepato-Pancreato-Biliary (HPB) and Upper GI Surgeon, Sydney South West Area Health Service
Chairman, NSW Pancreatic Cancer Network
Regius Chair of Surgery/Director of Translational Research Centre, University of Glasgow

Andrew and his team at The Kinghorn Cancer Centre are developing a personalised medicine strategy for pancreatic cancer based on genomic sequence data.

Andrew is a Surgeon Scientist who specialises in Pancreatic Diseases, particularly focusing on Pancreatic Cancer and its precursor lesions. His clinical practice is part of a specialist unit treating pancreatic disease. His research is focused on translating scientific discoveries into patient care through improved application of current therapies, early detection and novel therapeutics.

He is the clinical lead of the Australian Pancreatic Cancer Genome Initiative with Prof Sean Grimmond of the QCMG (scientific lead), which aims to sequence the genome, transcriptome and epigenome of approximately 400 pancreatic cancers as part of the International Cancer Genome Consortium.

Research Interests

Pancreatic cancer
Translational research

Awards and Honours

2010 - Landon Foundation-AACR INNOVATOR Award for International Collaboration in Cancer Research
2008 - Hirshberg Award for Pancreatic Cancer, American Pancreatic Association
2008 - Cancer Institute NSW Career Development and Support Fellowship
2007 - Cancer Institute NSW Premier's Award for Outstanding Cancer Research Fellow
2005 - Cancer Institute NSW Career Development and Support Fellowship
2005 - Cure Cancer Australia Young Investigator of the Year
2005 - Travel Award, Surgical Research Society of Australia
2004 - Excellence in Translational Research Award, Johns Hopkins University
2003 - Thesis Prize, Garvan Institute of Medical Research
2003-2006 - Neil Hamilton Fairley Postdoctoral Fellowship, National Health & Medical Research Council
2003 - Travelling Fellowship, Royal Australasian College of Surgeons
2002 - Travelling Fellowship, St Vincent's Clinic Foundation
2002 - Warren Fellowship (International Hepato-Pancreato-Biliary Association)
2001 - Annual St Vincent's Campus Research Symposium Award for excellence in research
2001 - Young Investigator Award, Johns-Hopkins Medical Institutions, Baltimore, Maryland, USA/The Lustgarten Foundation for Pancreatic Cancer Research
2001 - Travelling Fellowship, International Surgical Society
2000 - Annual St Vincent's Campus Research Symposium Award for excellence in poster presentation.
1999-2002 - National Health & Medical Research Council, Medical Postgraduate Scholarship
1999-2002 - Sir Roy McCaughey Fellowship, Royal Australasian College of Surgeons
1999 - Di Boyd Cancer Research Award, St Vincent's Clinic Foundation

Education

2004 - Postdoctoral Fellow, Department of Surgery, Johns Hopkins University, Baltimore - USA
2003 - PhD University of New South Wales - Australia
1999 - FRACS, Royal Australasian College of Surgeons
1992 - MB, BS (Hons), University of New South Wales - Australia
1988 - BMed Sc, University of New South Wales - Australia

Selected Publications

Hochgräfe F, Zhang L, O'Toole SA, Browne BC, Pinese M, Porta Cubas A, Lehrbach GM, Croucher DR, Rickwood D, Boulghourjian A, Shearer R, Nair R, Swarbrick A, Faratian D, Mullen P, Harrison DJ, Biankin AV, Sutherland RL, Raftery MJ, Daly RJ. (2010) Tyrosine phosphorylation profiling reveals the signaling network characteristics of Basal breast cancer cells. Cancer Res.15;70(22):9391-401. Epub Sep 21.

Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ, Chang DK, Liu PY, Jankowski K, Iraci N, Haber M, Norris MD, Keating J, Sekyere E, Jonquieres G, Stossi F, Katzenellenbogen BS, Biankin AV, Perini G, Liu T. (2010) Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Oncogene. 29(44):5957-68. Epub Aug 9.

Cheng K, Ho K, Stokes R, Scott C, Lau SM, Hawthorne WJ, O'Connell PJ, Loudovaris T, Kay TW, Kulkarni RN, Okada T, Wang XL, Yim SH, Shah Y, Grey ST, Biankin AV, Kench JG, Laybutt DR, Gonzalez FJ, Kahn CR, Gunton JE. (2010) Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. J Clin Invest. 120(6):2171-83. doi: 10.1172/JCI35846. Epub May 5

International Cancer Genome Consortium; Member of writing team (2010). International network of Cancer Genome Projects. Nature 464:993-8

Biankin AV, Kench JG, Colvin EK, Segara D, Scarlett CJ, Nguyen NQ, Chang DK, Skalicky DA, Morey AL, Lee CS, O’Toole SA, Pinese M, Kuo SCL, Susanto JM, Cosman PH, Lindeman GJ, Visvader JE, Merrett ND, Musgrove EA, Henshall SM, Sutherland RL. (2009) Expression of S100A2 calcium-binding protein Predicts Response to Pancreatectomy for Pancreatic Cancer. Gastroenterolgy. 137:558-68

Pinese M, Scarlett CJ, Kench JG, Colvin EK, Segara D, Henshall SM, Sutherland RL, Biankin AV. (2009) Messina: a novel analysis tool to identify biologically relevant molecules in disease. PLoS One. 4(4):e5337. Epub Apr 28.

Chang DK, Johns AL, Merrett ND et al. Margin clearance and outcome in resected pancreatic cancer. JClin Oncol 2009; 27(17):2855-2862.

Leong RWL, Nguyen N, Meredith CG et al. In vivo confocal endomicroscopy in the diagnosis and evaluation of celiac disease. Gastroenterology 2008; 135(6):1870-1876.

Pasca di Magliano M, Biankin AV, Heiser PW et al. Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One 2007; 2(11):e1155.

Henshall SM, Horvath LG, Quinn DI et al. Zinc-alpha2-glycoprotein expression as a predictor of metastatic prostate cancer following radical prostatectomy. J Natl Cancer Inst 2006; 98(19):1420-1424.

Prof Andrew Biankin