Associate Professor Antony Cooper
Senior Research Fellow, Diabetes & Obesity Research Program; Adjunct Senior Lecturer, School of Biotechnology and Biomolecular Sciences, The University of New South Wales
Email: a.cooper 'at' garvan.org.au
Research Group: Cooper
Education & Research
1981-1984 BSc (Honours) 1st Class Otago University, Dunedin, New Zealand
1985-1990 PhD McGill University, Montreal, Canada
1991-1995 Post-Doctoral Fellow, University of Oregon, Eugene, USA
1996-2006 Assistant/Associate Professor, University of Missouri, Kansas City, USA
Awards and Honours
2006 NSW Government BioFirst Award
2006 US Patent: Genes Suppressing Alpha-Synuclein Toxicity in Yeast Model System
2001 University of Missouri, Kansas City Faculty Scholar
1992 American Heart Association Post-doctoral Fellow
1990 US Patent: Protease for Specific Processing of Secreted Proteins
1990 McGill University, Dean of Research Honor’s List of Doctoral Theses of Merit
1985 Canadian Commonwealth Scholarship for Doctoral Studies
Publications
Kincaid MM, Cooper AA (In Press 2007) ERADicate ER Stress or Die Trying. Antioxidants and Redox Signaling.
Kincaid MM, Cooper AA. Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals. Mol Biol Cell 2007; 18(2):455-63.
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006; 313:324-8
Haynes C, Titus E, Cooper AA. Degradation of misfolded proteins prevents ER- derived oxidative stress and cell death. Molecular Cell 2004; 15(5):767-76
Haynes CM, Caldwell S, Cooper AA. An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. J Cell Biol 2002; 158(1):91-101.
Caldwell SR, Hill KJ, Cooper AA. Degradation of endoplasmic reticulum (ER) quality control substrates requires transport between the ER and Golgi. J Biol Chem 2001; 276(26):23296-303.
Hill K, Cooper AA. Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system. Embo J 2000; 19(4):550-61.
Cooper AA, Stevens TH. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. J Cell Biol 1996; 133(3):529-41.
Piper RC, Cooper AA, Yang H, Stevens TH. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol 1995; 131(3):603-17.
Cooper AA, Stevens TH. Protein splicing: self-splicing of genetically mobile elements at the protein level. Trends Biochem Sci 1995; 20(9):351-6.
Cooper AA, Chen YJ, Lindorfer MA, Stevens TH. Protein splicing of the yeast TFP1 intervening protein sequence: a model for self-excision. Embo J 1993; 12(6):2575-83.
