Dr Bryce Vissel

Lab Head - Neurodegenerative Diseases

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Dr Vissel completed his PhD at University of Melbourne and then spent 10 years at the Salk Institute in the USA, working as a senior scientist at the world’s leading neuroscience laboratory (based on worldwide scientific rankings).

Dr Vissel was recruited to Australia from the Salk Institute in the USA to establish and lead research for brain and spinal cord repair, with the assistance of the State Government of NSW.  His work gained international recognition and he received a number of awards, including the prestigious Fulbright award, a Liebermann award and a BIOFIRST award. He has a record of leadership and team building.

Dr Vissel is on the Advisory Boards of Alzheimer’s Australia, Parkinson’s NSW and SpinalCure Australia. He was a founder of Spinal Cord Injury Network. He has strong links to cancer researchers. Dr Vissel also regularly appears in the media and has advised State and Federal Goverrnment, committees, ministers and advisors as well as industry.  He has strong international links and strong links to leading clinicians. 

Research Interests

Alzheimer’s disease
Parkinson’s disease
Spinal cord injury
motor neuron disease’
Neurodegeneration / neurodegenerative diseases
Regeneration of the brain and spinal cord
Neurogenesis
Stem cells
Learning and memory
Movement and Movement disorders
Dementia
Preclinical and translational research
Neuro-inflammation
Inflammation
Glial cells (microglia and astrocytes)
Excitotoxicity
Synapses Synaptic transmission, synapses, neural circuits
Advanced behavioural studies, microscopy, molecular biology, biochemistry, advanced imaging techniques

Awards and Honours

2003 - BIOFIRST award
2000 - Liebermann award
1998 - Fulbright award
1996 - NHMRC CJ Martin Award
1994 - EMBO Award
1991 - William Shopee Prize

Education

1991 - PhD, University of Melbourne - Australia
1984 - B Pharm (Hons 1), Sydney University - Australia

Selected Publications

Zelikowsky M, Bissiere S, Hast TA, Bennett RZ, Abdipranoto A, Vissel B, Fanselow MS. Prefrontal microcircuit underlies contextual learning after hippocampal loss. Proc Natl Acad Sci USA. 2013; 110(24):9938-43.  

Wright AL, Zinn R, Hohensinn B, Konen LM, Beynon SB, Tan RP, Clark IA, Abdipranoto A, Vissel B. Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease. PLoS One. 2013; 8(4):e59586.   

Clark I, Atwood C, Bowen R, Paz-Filho G, Vissel B. Tumor necrosis factor-induced cerebral insulin resistance in Alzheimer's disease links numerous treatment rationales. Pharmacol Rev. 2012; 64(4):1004-26.

Wiltgen BJ, Royle GA, Gray EE, Abdipranoto A, Thangthaeng N, Jacobs N, Saab F, Tonegawa S, Heinemann SF, O'Dell TJ, Fanselow MS, Vissel B.  A role for calcium-permeable AMPA receptors in synaptic plasticity and learning. PLoS One. 2010; 5(9)pii: e12818.

Galbraith S, Daniel JA, Vissel B. A study of clustered data and approaches to its analysis. J Neurosci. 2010; 30(32):10601-8.    

Daniel JA, Galbraith S, Iacovitti L, Abdipranoto A, Vissel B. Functional heterogeneity at dopamine release sites. J Neurosci. 2009; 29(46):14670-80.  

Abdipranoto-Cowley A, Park JS, Croucher D, Daniel J, Henshall S, Galbraith S, Mervin K, Vissel B.  Activin A is essential for neurogenesis following neurodegeneration. Stem Cells. 2009; 27(6):1330-46. 

Abdipranoto A, Wu S, Stayte S, Vissel B. The role of neurogenesis in neurodegenerative diseases and its implications for therapeutic development. CNS Neurol Disord Drug Targets. 2008; 7(2):187-210. 

Sans N, Vissel B, Petralia RS, Wang YX, Chang K, Royle GA, Wang CY, O'Gorman S, Heinemann SF, Wenthold RJ. Aberrant formation of glutamate receptor complexes in hippocampal neurons of mice lacking the GluR2 AMPA receptor subunit. J Neurosci. 2003; 23(28):9367-73.  

Sekirnjak C, Vissel B, Bollinger J, Faulstich M, du Lac S. Purkinje cell synapses target physiologically unique brainstem neurons. J Neurosci. 2003; 23(15):6392-8. 

South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT, Ohata M, Jenab S, Sailer AW, Malkmus S, Masuyama T, Horner P, Bogulavsky J, Gage FH, Yaksh TL, Woolf CJ, Heinemann SF, Inturrisi CE. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci. 2003; 23(12):5031-40.  

31. Kaspar BK, Vissel B, Bengoechea T, Crone S, Randolph-Moore L, Muller R, Brandon EP, Schaffer D, Verma IM, Lee KF, Heinemann SF, Gage FH. Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci USA. 2002; 99(4):2320-5.   

Vissel B, Krupp JJ, Heinemann SF, Westbrook GL. A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat Neurosci. 2001; 4(6):587-96.  

Vissel B, Royle GA, Christie BR, Schiffer HH, Ghetti A, Tritto T, Perez-Otano I, Radcliffe RA, Seamans J, Sejnowski T, Wehner JM, Collins AC, O'Gorman S, Heinemann SF. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron. 2001; 29(1):217-27.  

Krupp JJ, Vissel B, Heinemann SF, Westbrook GL. N-terminal domains in the NR2 subunit control desensitization of NMDA receptors. Neuron. 1998; 20(2):317-27.

Dr Bryce Vissel