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Dr Cecile King

 

Senior Research Fellow; Group leader, Immunology Program, Garvan Institute of Medical Research

Email: c.king 'at' garvan.org.au
Research Group: Mucosal Autoimmunity

 
 
Cecile established her Lab at the Garvan in 2005 after completing post-doctoral research on type 1 diabetes at the Scripps Research Institute. While at TSRI, Cecile focused on how cytokines can act on specific immune cells to influence the development of type-1 diabetes. Cecile’s group is looking at the role of genetically linked cytokines in immunity and autoimmunity.
 
 
 

Education

PhD Institute for Child Health Research, University of Western Australia
BSc University of Western Australia

Publilcations

Cecile King and Nora Sarvetnick (2011). The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. Plos One, in press.

Helen M. McGuire, Stacey Walters, Alexis Vogelzang, Carol M.Y. Lee, Kylie E. Webster, Jonathan Sprent, Daniel Christ, S. Grey and Cecile King (2011). Interleukin-21 Is Critically Required in Autoimmune and Allogeneic Responses to Islet Tissue in Murine Models. Diabetes; 60(3):867-75.

Carol MY Lee, Helen McGuire, Antony Basten, Cecile King and Daniel Christ (2010). Expression, purification and characterization of recombinant interleukin-21. J. Immunol. Methods. Oct 31; 362(1-2): 185-189.

Helen McGuire, Alexis Vogelzang, Natasha Hill, Malin Flodström-Tullberg, Jonathan Sprent and Cecile King (2009). Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus. Proceedings of the national academy of Sciences (PNAS) Nov 17;106(46):19438-43.

Cecile King (2009). New insights into the development and function of T follicular helper cells. Nat Rev Immunol. Nov;9(11):757-66.

Yu D, Batten M, Mackay CR, King C (2009). Lineage specification and heterogeneity of T follicular helper cells. Curr Opin Immunol. Dec;21(6):619-25.

Alexis Vogelzang, Helen M. McGuire, Jon Sprent Charles R. Mackay and Cecile King (2008). A fundamental role for IL-21 in T helper cell differentiation. Immunity, Jul;29(1):127-37

Ivo Sonderegger, Reto Meier, Cecile King, Manfred Kopf (2008). IL-21R is not required for development of Th17 mediated autoimmunity Eur J Immunol. Jul;38(7):1833-8

Cecile King, Stuart G. Tangye and Charles R. Mackay (2008). T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol. 26:741-66.

Natasha J. Hill, Cecile King and Malin Flodström-Tullberg (2007). Recent acquisitions on the genetic basis of autoimmune disease. Front Biosci. May 1;13:4838-5.

Cecile King, Alex Ilic, Kersten Koelsch and Nora Sarvetnick (2004). Homeostatic expansion of T cells during immune insufficiency generates autoimmunity Cell, 117, 265-277.

Cecile King, Regula Mueller, Mary Malo Cleary, Murali Krishner, Rafi Ahmed, Ernest King and Nora Sarvetnick (2002). Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T cell responses. Nature Medicine, 7, 206-214.

Cecile King, Joanna Davies, Regula Mueller, Myung-Shik Lee, Troy Krahl, Brian Yeung, Eric O'Connor and Nora Sarvetnick (1998). TGF-B1 alters APC preference, polarizing islet antigen responses to Th2. Immunity, 8, 601-613.

Cecile King and Nora Sarvetnick (1997). Organ-specific autoimmunity (Review). Current Opinion in Immunology, 9 (6): 863-71

 

Search for all publications by Cecile King

 
 
 

Areas of Interest

Autoimmunity, type 1 diabetes, mucosal immunity, tolerance
 

News

 

Breakthrough study links Type 1 diabetes and Sjogren’s syndrome

MEDIA RELEASE: 22 Apr 2011
Garvan scientists have identified a new group of immune cells that for the first time directly link two autoimmune diseases, Type 1 diabetes and Sjogren’s syndrome. Autoimmune diseases arise when the body’s defences become overactive, and instead of attacking invading microbes, it starts to attack itself. In the case of Type 1 diabetes, the body attacks insulin-producing cells in the pancreas. In the case of Sjogren’s syndrome, it attacks its own salivary glands.
 
 

Potential anti-rejection drug for insulin cell transplantation

MEDIA RELEASE: 01 Mar 2011
Garvan scientists have developed a reagent with the potential to prevent rejection of transplanted insulin-producing cells into people with Type 1 diabetes – one of the most promising immunology developments in recent years.
 
 

The genetic fuse that may ignite Type 1 diabetes

MEDIA RELEASE: 20 Oct 2009
Garvan scientists have discovered that a tiny genetic irregularity, which boosts the expression of a key gene, may lead to the development of Type 1 diabetes. While there is no cure yet, prevention therapies are on the horizon, making the development of reliable screening tools critical. And that's where the current finding has promise.
 
 

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