Dr Daniel Christ
Senior Research Officer; Group Leader, Immunology and Inflammation, Immunology Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer Faculty of Medicine, The University of New South Wales
Email: d.christ "at"garvan.org.au
Research Group: Antibody Engineering
After undergraduate studies in Switzerland, Daniel joined Sir Gregory Winter's laboratory at Cambridge University for his PhD. Winter had shown that in-vitro evolution technology (such as phage display) can be used for the generation of therapeutic antibodies, initiating a multi-billion dollar biotechnology industry. At Cambridge, Daniel was able to demonstrate that in-vitro evolution can be applied to molecules others than antibodies and can help to decipher the evolutionary origins of proteins. He was elected a Fellow of Trinity College (Cambridge University) at age 29. He maintains close links with industry and was involved the foundation of Domantis Ltd, (now GSK), for which he worked as a consultant for many years. Daniel joined the Garvan in 2007 to head the newly established antibody engineering lab.
Education
2003 PhD, Cambridge University
1999 Dipl. Natw. (M.Sc.), Swiss Federal Institute of Technology (ETH)
Awards and Honours
2002 Fellow, Trinity College, Cambridge University
1999 Studer Prize, Swiss Federal Institute of Technology (ETH)
Publications
Lee CM, Iorno N, Sierro F & Christ D. Selection of human antibody fragments by phage display. Nat Protoc 2007; 2(11):3001-3008
Famm K, Hansen L, Christ D & Winter G. Thermodynamically stable aggregation-resistant antibody domains through directed evolution. J Mol Biol 2007; doi: 10.1016/j.jmb.2007.10.075.
Christ D, Famm K, Winter G. Repertoires of aggregation-resistant human antibody domains. Protein Eng Des Sel 2007; 20(8):413-416.
Christ D, Famm K, Winter G. Tapping diversity lost in transformation - in vitro amplification of ligation reactions. Nucl Acids Res 2007; 34(16):e108.
Christ D, Winter G. Identification of protein domains by shotgun proteolysis. J Mol Biol 2006; 358(2):364-371.
Christ D, Winter G. Identification of functional similarities between proteins by directed evolution. Proc Natl Acad Sci U S A 2003; 100(23):13202-13206.
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