Dr Ilse Rooman
Senior Research Officer; Group leader, Pancreatic Carcinogenesis Group, Cancer Program, Garvan Institute of Medical Research
Email: i.rooman 'at' garvan.org.au
Research Group: Pancreatic Carcinogenesis
Ilse leads the Pancreatic Carcinogenesis group, which is focused on identifying key drivers and biomarkers of pancreatic cancer through studying the earliest cellular changes in the exocrine pancreas with the aim to define novel screening and therapeutic targets.
Education
2002 Ph.D. Medical Sciences (Biomedical Sciences), Vrije Universiteit Brussel, Brussels, Belgium
1996 Graduate in Biomedical Sciences, Vrije Universiteit Brussel, Brussels, Belgium
Awards and Honours
2011 Future Research Leader, Cancer Institute NSW (Australia)
2009 Research Professorship, Free University Brussels (VUB) (Belgium)
2009 Francqui Foundation Professorship (Belgium)
2008 Marie Curie Reintegration Grant (EU)
2006 MarieCurie Intra-European fellowship (EU)
2005 post-doctoral fellowship, Fund for Scientific Research–Flanders (Belgium)
2003 Ishango-prize for young scientists, Minister-president of the Brussels government (Belgium)
2002 Prize of the fund Dr. Karel-Lodewijk Verleysen (Belgium)
2002 Aventis award in Diabetes
2002 post-doctoral fellowship, Fund for Scientific Research-Flanders (Belgium)
1996 EASD-Bayer Travel Fellowship
1996 Ph.D. Fellowship, Fund for Scientific Research-Flanders (Belgium)
Selected Publications
Rooman I and Real FX. Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development? Gut (2011), accepted for publication
Houbracken I, De Waele E, Lardon J, Ling Z, Heimberg H, Rooman I, Bouwens L. Lineage Tracing Evidence for Transdifferentiation of Acinar to Duct Cells and Plasticity of Human Pancreas. Gastroenterology (2011), in press
Pinho AV, Rooman I*, De Medts N, Reichert M, Rustgi AK, Bouwens L, Real FX. Pancreatic acinar cells can acquire an embryonic progenitor phenotype and activate a senescence program that is present in chronic pancreatitis. Gut (2010) Dec 30. [Epub ahead of print] *equally contributing first author
Martínez-Romero C, Rooman I*, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I. The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. J Pathol 219:205-13 (2009) *equally contributing first author
Rooman I, De Medts N, Baeyens L, Lardon J, De Breuck S, Heimberg H, Bouwens L. Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas. Am J Pathol 169, 1206-1214 (2006)
Bouwens L, Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev 85, 1255-1270 (2005)
Rooman I, Bouwens L. Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan. Diabetologia 47, 259-65 (2004)
Rooman I, Lardon J, Bouwens L. Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue. Diabetes 51, 686-90 (2002)
Rooman I, Lardon J, Flamez D, Schuit F, Bouwens L. Mitogenic effect of gastrin and expression of gastrin receptors in duct-like cells of rat pancreas. Gastroenterology 121, 940-9 (2001)
Rooman I, Heremans Y ,Heimberg H, Bouwens L. Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro. Diabetologia 43(7), 907-14 (2000)
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