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Dr Marcel Batten

 

Senior Research Officer, Group Leader, Immunobiology of Cytokines, Immunology Program, Garvan Institute of Medical Research; Lecturer (conjoint appointment), The University of New South Wales

Email: m.batten 'at' garvan.org.au
Research Group: Immunobiology of Cytokines

 
 
Marcel carried out her PhD studies on the development of systemic autoimmune disease at the Garvan Institute before venturing over to San Francisco as a post doctoral fellow at Genentech Inc. Returning to the Garvan Institute at the beginning of 2009, her primary area of interest involves the study of how cytokines of the IL-12 family coordinate interactions between various immune cells.
 
 
 

Marcel’s group is interested in studying how newly discovered cytokines work during normal immune responses to infection as well as how they are involved in autoimmune disease and whether they can activate the immune system to delete emerging tumours.  This will inform us as to whether the new cytokines could be valuable new therapeutic targets in these diseases.

Education

2004 PhD The University of New South Wales

2000 BSc (Hons1) The University of New South Wales

Publications

Fernandez HR, Batten M, Kugathasan K, Lutze-Mann LH. Long-term mutagenic effects of ionising radiation on mice which vary in their p53 status. DNA Repair (Amst) 2008; 7:641-7.

Batten M, Kljavin NM, Li J, Walter MJ, de Sauvage FJ, Ghilardi N. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J Immunol 2008; 180:2752-6.

Marino E, Batten M, Groom J, Walters S, Liuwantara D, Mackay F, Grey ST. Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells. Diabetes 2008; 57:395-404.

Batten M, Ghilardi N. The biology and therapeutic potential of interleukin 27. J Mol Med 2007; 85:661-72.

Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, Lee J, de Sauvage FJ, Ghilardi N. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 2006; 7:929-36.

Batten M, Fletcher C, Ng LG, Groom J, Wheway J, Laabi Y, Xin X, Schneider P, Tschopp J, Mackay CR, Mackay F. TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol 2004; 172:812-22.

Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, Mauri D, Cavill D, Gordon TP, Mackay CR, Mackay F. Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest 2002; 109:59-68.

Batten M, Groom J, Cachero TG, Qian F, Schneider P, Tschopp J, Browning JL, Mackay F. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 2000; 192:1453-66.

 

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