Dr Matthew Naylor
Senior Research Officer; Group Leader, Integrin & Cell Biology, Cancer Research Program, Garvan Institute of Medical Research; Conjoint Lecturer, Faculty of Medicine, University of New South Wales
Email: m.naylor'at'garvan.org.au
Research Group: Integrin and Cell Biology
Education
2003 PhD, University of New South Wales
1999 BSc (Hons I), University of Western Sydney
Awards
2007 Cancer Institute NSW Fellowship
2004 CJ Martin Fellowship (declined) and Peter Doherty Fellowship (accepted), National Health & Medical Research Council of Australia.
2000 Young Researcher of the Year Award, St Vincent’s Campus Research Symposium
1999 University of New South Wales, Faculty of Medicine, Deans Research
Scholarship
1998 Linbrook Medal for Academic Excellence, UWS
1997 Cooperative Education for Enterprise Development (CEED) award funded by Fort Dodge Australia Pty Limited and UWS
Selected Publications
Oakes SR*, Naylor MJ*, Asselin-Labat ML, Blazek KD, Gardiner-Garden M, Hilton HN, Kazlauskas M, Pritchard MA, Chodosh LA, Pfeffer PL, Lindeman GJ, Visvader JE and Ormandy CJ. The Ets transcription factor Elf5 is essential for specifying mammary alveolar cell fate. Genes Dev 2008; 22: 581-586. *Co-first authors
Harris J, Stanford P, Sutherland K, Oakes SR, Naylor MJ, Robertson FG, Blazek K, Kazlauskas M, Wittlin S, Alexander WS, Linderman GJ, Visvader JE and Ormandy CJ. Socs2 and Elf5 are key members of the set of prolactin-regulated genes that drive mammary gland development. Mol Endocrinol 2006; 20:1177-87.
Naylor MJ, Li N, Cheung J, Lowe EA, Lambert E, Wang P, Marlow R, Schatzmann F, Wintermantel T, Schuetz G, Clarke AR, Mueller U, Hynes NE and Streuli CH. Ablation of β1 integrins in mammary epithelium reveals a critical role for integrin in glandular morphogenesis and differentiation. J Cell Biol 2005; 171:717-28
Li N, Zhang Y, Naylor MJ, Schatzmann F, Maurer F, Wintermantel T, Schuetz G, Mueller U, Streuli CH and Hynes NE. β1 integrins regulate mammary gland proliferation and maintain the integrity of mammary luminal alveoli. EMBO J 2005; 24:1942-53.
Naylor MJ, Oakes SR, Gardiner-Garden M, Harris J, Blazek K, Ho TWC, Li FC, Wynick D, Walker AM and Ormandy CJ. Investigation of the transcriptional changes underlying the secretory activation phase of mammary gland development. Mol Endocrinol 2005; 19:1868-83.
Zhou J, Chehab R, Tkalcevic J, Naylor MJ, Harris J, Wilson TJ, Tsao S, Tellis I, Zavarsek S, Xu D, Lapinskas EJ, Visvader J, Lindeman GJ, Thomas R, Ormandy CJ, Hertzog PJ, Kola I, and Pritchard MA. Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation. EMBO J 2005; 24: 635-44.
Green KA, Naylor MJ, Lowe ET, Wang P, Marshman E and Streuli CH. Caspase-mediated cleavage of insulin receptor substrate. J Biol Chem 2004; 279: 25149-25156.
Naylor MJ, Ginsburg E, Iismaa, TP, Vonderhaar BK, Wynick D and Ormandy CJ. The neuropeptide galanin augments lobuloalveolar development. J Biol Chem 2003; 278: 29145-29152.
Naylor MJ and Ormandy CJ. Mouse strain-specific patterns of mammary ductal side branching are elicited by stromal components. Dev Dynamics 2002; 225: 100-105
Lindeman GJ, Wittlin S, Lada H, Naylor MJ, Santamaria M, Zhang, JG, Starr R, Hilton DJ, Alexander WS, Ormandy CJ and Visvader J. SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice. Genes Dev 2001; 15: 1631-1636.
