Dr Nigel Turner
Senior Research officer; Group Leader, Diabetes and Obesity Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Faculty of Medicine, The University of New South Wales
Email: n.turner 'at' garvan.org.au
Research Group: Turner
Education
2004 PhD (Comparative Physiology and Biochemistry) University of Wollongong
1999 BSc (Hons 1) University of Wollongong
Awards
2010 Australia Society of Medical Research, NSW meeting – Best postdoctoral poster
2008 NHMRC Career Development Award
2007 Scientific Travel Grant, Australian Academy of Science
2006 Keystone Symposia Scholarship
2006 EASD Travel Fellowship
2005 NHMRC Peter Doherty Fellowship
2000 Australian Postgraduate Award
2000 University Medal, Health and Behavioural Sciences, University of Wollongong
Publications
Wright LE, Brandon AE, Hoy AJ, Forsberg G-B, Lelliott CJ, Reznick J, Löfgren L, Oscarsson J, Strömstedt M, Cooney GJ & Turner N. Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1β involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia (in press)
Hoehn KL, Turner N (co-first author), Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE & Cooney GJ. (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole body energy expenditure or adiposity. Cell Metab 11: 70-76.
Qiu B, Turner N, Li Y, Gu M, Huang M, Wu F, Pang T, Nan F, Ye J, Li J & Li J. (2010). A high-throughput assay for modulators of mitochondrial membrane potential identifies a novel compound with beneficial effects on db/db mice. Diabetes 59:256-265.
Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li J, Kraegen EW, Cooney GJ & Ye J. (2009). Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species-dependent: Potent tissue-specific effects of medium chain fatty acids. Diabetes 58:2547-2554.
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Cooney GJ, Richardson A, & James DE. (2009). Insulin Resistance is a Cellular Antioxidant Defence Mechanism. Proc Natl Acad Sci 106:17787-17792.
Turner N & Heilbronn LK. (2008). Is mitochondrial dysfunction a cause of insulin resistance? Trends Endocrinol Metab 19: 324-330.
Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, Ebina Y & James DE. (2008). IRS1-independent defects define major nodes of insulin resistance. Cell Metab 7: 421–433.
Turner N, Li J, Gosby A, To SWC, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE, Hu L, Li J & Ye J. (2008). Berberine, and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory Complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 57:1414–1418.
Tan M, Ye J, Turner N (co-first author), Hohnen-Behrens C, Ke C, Tang C, Rowland A, Chen T, Weiss H, Gesing E, James DE & Ye Y. (2008). Anti-diabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem Biol 15: 263–273.
Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS & Cooney GJ. (2007). Excess lipid availability increases mitochondrial fatty acid oxidative capacity in skeletal muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 56: 2085–2092.
