Dr Ross Laybutt
Senior Research Fellow; Group Leader, Diabetes and Obesity Research Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, The University of New South Wales
Email: r.laybutt 'at' garvan.org.au
Research Group: Laybutt
Education
1994 BSc (Hons) Class 1, The University of New South Wales
1998 PhD, The University of New South Wales
Awards and Honours
1999 Juvenile Diabetes Foundation Post-Doctoral Fellowship (USA)
2002 RD Wright Biomedical Career Development Award (NHMRC)
2005 NHMRC Early Career Researcher Award, Australian Academy of Science
Publications
Åkerfeldt MC, Howes J, Chan JY, Stevens VA, Boubenna N, McGuire HM, King C, Biden TJ, Laybutt DR. Cytokine-induced β-cell death is independent of endoplasmic reticulum stress signalling. Diabetes 2008; 57:3034-3044
Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation. Diabetologia 2007; 50:2117-2125
Schmitz-Peiffer C, Laybutt DR, Burchfield JG, Gurisik E, Narasimhan S, Mitchell CJ, Pedersen DJ, Braun U, Cooney GJ, Leitges M, Biden TJ. Inhibition of PKC epsilon improves glucose-stimulated insulin secretion and reduces insulin clearance. Cell Metab 2007; 6:320-328
Laybutt DR, Preston AM, Åkerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ. Endoplasmic reticulum stress contributes to β-cell apoptosis in type 2 diabetes. Diabetologia 2007; 50: 752-763
Kjørholt C, Åkerfeldt MC, Biden TJ, Laybutt DR. Chronic Hyperglycemia, Independent of Plasma Lipid Levels, Is Sufficient for the Loss of {beta}-Cell Differentiation and Secretory Function in the db/db Mouse Model of Diabetes. Diabetes 2005; 54(9):2755-63.
Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC. Critical reduction in β-cell mass results in two distinct outcomes over time. J Biol Chem 2003; 278:2997-3005.
Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas J-C, Groff A, Ferran F, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes 2002; 51:413-423
Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in β-cells disrupted by hyperglycemia. J Biol Chem 2002; 277:10912-21
Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression and diabetes. Diabetes 2002; 51:1793-1804
Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell 2001; 7:1165-1176
