Dr Shane T Grey
Senior Research Fellow; Group Leader, Gene Therapy & Autoimmunity Group, Immunology and Inflammation Program, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Department of Medicine, The University of New South Wales
Email: s.grey 'at' garvan.org.au
Research Group: Gene Therapy and Autoimmunity
Education
1999 Post Doctoral Fellow Harvard Medical School, Boston, USA
1994 PhD Monash University, Melbourne
1988 BSc(Hons) Monash University, Melbourne
1985 Bsc La Trobe University, Melbourne
Awards and Honours
2005 Mary Jane Kugel Award, Juvenile Diabetes Research Foundation International, USA
2003 NSW Biofirst Award, Australia
2001 Boston Area Diabetes and Endocrinology Research Center Pilot Project Award (NIH), USA
2000 Career Development Award, Juvenile Diabetes Research Foundation International, USA
Publications
Mariño E, Batten M, Groom J, Walters S, Liuwantara D, Mackay F, Grey ST: Marginal-zone B-cells of nonobese diabetic mice expand with diabetes onset, invade the pancreatic lymph nodes, and present autoantigen to diabetogenic T-cells. Diabetes 2008; 57:395-404.
Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST. Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection. Diabetes 2006; 55(9):2491-501.
Silveira PA, Grey ST. B cells in the spotlight: innocent bystanders or major players in the pathogenesis of type 1 diabetes. Trends Endocrinol Metab 2006; 17(4):128-35.
Soizic D, Arvelo MB, Patel VI, Longo CR, Shrikhande G, Shukri T, Mahiou J, Sun DW, Mottley C, Grey ST, Ferran C. A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation. Blood 2004; 104(8):2376-84.
Hartman MG, Lu D, Kim ML, Kociba GJ, Shukri T, Buteau J, Wang X, Frankel WL, Guttridge D, Prentki M, Grey ST, Ron D, Hai T. Role for activating transcription factor 3 in stress-induced beta-cell apoptosis. Mol Cell Biol. 2004 Jul;24(13):5721-32.Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003; 112(12):1831-42.
Grey ST, Longo C, Shukri T, Patel VI, Csizmadia E, Daniel S, Arvelo MB, Tchipashvili V, Ferran C. Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. J Immunol 2003; 170(12):6250-6.
Grey ST, Arvelo MB, Hasenkamp W, Bach FH, Ferran C. A20 inhibits cytokine-induced apoptosis and NF β dependent gene activation in islets. J Exp Med 1999; 190 (8): 1135-1145.
