Dr Will Hughes
Senior Research Fellow; Group Leader Diabetes and Obesity Research Program and Director Molecular Imaging Facility, Garvan Institute of Medical Research; Conjoint Senior Lecturer, Faculty of Medicine, The University of New South Wales
Email: w.hughes 'at' garvan.org.au
Research Group: Hughes
Education
1996 PhD University of Leicester, UK
1992 MSc University of Leicester, UK
1990 BSc (Hons) University of Bristol, UK
Awards
2002 Howard Florey Centenary Fellowship
2002 Royal Society Travelling Fellowship
1998 ICRF Postdoctoral Research Fellowship
1996 GlaxoWellcome Postdoctoral Research Fellowship
Publications
McGuire, H. M., Vogelzang, A., Ma, C. S., Hughes, W. E., Silviera, P., Tangye, S. G., Christ, D., Fulcher, D., Falcone, M. and C. King (2011). A novel subset of IL-21 producing T helper cells that co-express CCR9 target accessory organs of the digestive system for autoimmunity. Immunity, 34, 602-615.
Herrera-Abreu, M. T., Hughes, W. E., Mele, K., Lyons, R. J., Rickwood, D., Browne, B. C., Bennett, H., Vallotton, P., Brummer, T. and R. J. Daly (2011) Gab2 regulates cytoskeletal organization and migration of mammary epithelial cells by modulating RhoA activation. Molecular Biology of the Cell, 22, 105-116.
Passam, F. H., Rahgozar, S., Qi, M., Raftery, M. J., Wong, J. W. H., Tanaka, K., Ioannou, Y., Zhang, J. Y., Gemmell, R., Qi, J. C., Giannakopoulos, B., Hughes, W. E., Hogg, P. J. and S. A. Krillis (2010) Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116, 1995-1997.
Naughtin, M.J., Sheffield, D.A., Rahman, P., Hughes, W.E., Gurung, R., Stow, J.L., Nandurkar, H.H., Dyson, J.M. and Mitchell, C.A. (2010) The myotubularin phosphatase, MTMR4, regulates sorting from early endosomes. Journal of Cell Science, 123, 3071-3083.
Passam, F.H., Rahgozar, S., Qi, M., Raftery, M.J., Wong, J.W.H., Tanaka, K., Gemmell, R. Giannakopoulos, B. Qi, J.C., Ioannou, Y., Zhang, J.Y., Hughes, W.E., Hogg, P.J and S. A. Krillis (2010) Redox control of β2GPI-von Willebrand factor interaction by thioredoxin-1. Journal of Thrombosis and Haemostasis, 8, 1754-1762.
Burchfield, J. G., Lopez, J. A., Mele, K., Vallotton, P., James, D. E. and W. E. Hughes (2010) Exocytotic Vesicle Behaviour Assessed by Total Internal Reflection Fluorescence Microscopy. Traffic, 11, 429-439
Mele, K., Burchfield, J. G., Lopez, J. A., James, D. E. Hughes, W. E. Coster, A. and P. Vallotton (2009) TIRF Microscopy Software for Automated Vesicle Fusion Detection. American Biotechnology Laboratory, 27, 8-9
Mele, K., Vallotton, P., Burchfield, J. G., James, D. E. and W. E. Hughes (2009) Towards fully automated Identification of Vesicle-Membrane Fusion Events in TIRF Microscopy. International Journal of Computer Aided Engineering and Technology, 1, 502-515.
Lopez, J. A., Burchfield, J. G., Blair, D. H., Mele, K., Ng, Y., Vallotton, P. A., James, D. E. and W. E. Hughes (2009) Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20, 3918-3929.
Cazzolli, R., Huang, P. Teng, S and W. E. Hughes (2009) Measuring Phospholipase D activity in Insulin secreting and Insulin Responsive Cells and Tissues. Methods in Molecular Biology 462, 241-251.
Katsoulotos, G. P., Qi, M., Qi, J. C., Tanaka, K., Hughes, W. E. Molloy, T. J., Adachi, R., Stevens, R. L. and S. A. Krilis, (2008) The Diacylglycerol Dependent Translocation of Ras Guanine Nucleotide-Releasing Protein 4 (RasGRP4) Inside a Human Mast Cell Line Results in Substantial Phenotypic Changes Including Expression of the Interleukin 13 Receptor IL13Rα2. Journal of Biological Chemistry 283, 1610-1621.
