Professor Herbert Herzog
Leader, Neuroscience Research Program, Garvan Institute of Medical Research; NHMRC Principal Research Fellow; Adjunct Professor, Faculty of Medicine, The University of New South Wales
Email: h.herzog 'at' garvan.org.au
Research Group: Eating Disorders
In 1991, Herbert joined the Garvan Institute and was the first to isolate and characterise a member of the Neuropeptide Y (NPY) receptor family. He has continued to study the molecular biology, genetics and pharmacology of NPY receptors and investigate the numerous functions of neuropeptide signalling. Herbert’s current work focuses mostly on the brain’s role in the regulation of eating behaviour, energy storage and stress.
Education
1996 Habilitation - Priv. Doz. (Doctor of Science), Free University of Berlin (Germany)
1989 Doktorprüfung - Dr. rer. nat., University of Innsbruck (Austria)
1986 Diplomprüfung Chemie - Mag. rer. nat., University of Innsbruck, (Austria)
1980 - 1986 Study of Chemistry, University of Innsbruck, (Austria)
Awards and Honours
2009 Victor Mutt Award (International Regulatory Peptide Society)
2007 NHMRC Principal Research Fellowship (Australia)
2000 Wellcome Trust Short Term Travel Fellowship (UK)
1991 Erwin Schrödinger Fellowship (Austria)
Publications
Cox H.M, Iain R, Tough R.I, Woolston A.M, Zhang L, Nguyen A.D, Sainsbury A and Herzog H (2010) Peptide YY is critical for Gpr119-induced activation of gastrointestinal mucosal responses and effects on glucose tolerance. Cell Metabolism. In press
Lin S, Shi YC, Yulyaningsih E, Aljanova A, Zhang L, Macia L, Nguyen A.D, Lin EJ, During M.J, Herzog H, & Sainsbury A (2009) Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLOS One 4(12):e8488.
Baldock P.A, Lee N.J, Driessler F, Lin S, Allison S, Stehrer B, Lin EJ, Zhang L, Enriquez R.F, Wong I.PL, McDonald M.M, During M, Pierroz D.D, Slack K, Shi YC, Yulyaningsih E, Aljanova A, Little D.G, Ferrari S.L, Sainsbury A, Eisman J.A, & Herzog H (2009) Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to bodyweight. PLOS One 4(12):e8415.
Stanic, D., Paratcha, G., Ledda, F., Herzog, H., Kopin, A.S. & Tomas Hökfelt (2008) Peptidergic influences on proliferation, migration and placement of neural progenitors in the adult mouse forebrain. Proc. Natl. Acad. Sci. U.S.A., 105(9), 3610-5.
Johnen H, Lin S, Kuffner T, Brown D.A, Tsai VWW, Bauskin A.R, Wu L, Pankhurst G, Jiang L, Junankar S, Hunter M, Fairlie W, Lee N.J, Enriquez R, Baldock P.A, Corey E, Apple F.S, Murakami M.M, Lin EJ, Wang C, During M.J, Sainsbury A, Breit* SN & Herzog* H Tumour-induced anorexia and weight loss are mediated by the TGF-≤ superfamily cytokine MIC-1. Nat. Med 2007 13(11):1333-1340. * equal last author
Kuo LE, Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, Lee EW, Burnett MS, Fricke ST, Kvetnansky R, Herzog H, Zukowska Z. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007; 13(7):803-11.
Batterham RL, Heffron H, Kapoor S, Chivers JE, Chandarana K, Herzog H, Le Roux CW, Thomas EL, Bell JD, Withers DJ. Critical role for peptide YY in protein-mediated satiation and body-weight regulation. Cell Metab 2006; 4(3):223-33.
Wheway J, Mackay CR, Newton RA, Sainsbury A, Boey D, Herzog H, Mackay F. A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J Exp Med 2005; 202(11):1527-38.
Karl T, Lin S, Schwarzer C, Sainsbury A, Couzens M, Wittmann W, Boey D, von Horsten S, Herzog H. Increased aggressive behaviour revealed in Y1 knockout mice. P Natl Acad Sci USA 2004; 101(34):12742-12747.
Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA, Cone RD, Bloom SR. The gut hormone, PYY3-36, physiologically inhibits food intake. Nature 2002; 418:650-654.
Sainsbury A, Schwarzer C, Couzens M, Fetissov S, Fürtinger S, Jenkins A, Cox HM, Sperk G, Hökfelt T, Herzog H. Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. P Natl Acad Sci USA 2002; 99:8938-8943.
Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, Ormandy CJ, Herzog H. Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev 2002; 16:1077-1088.
Baldock PA, Sainsbury A, Couzens M, Enriquez RF, Thomas GP, Gardiner EM, Herzog H. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002; 109:915-921.
Herzog H, Hort Y, Schneider R, Shine J. Seminalplasmin: recent evolution of a new member of the neuropeptide Y gene family. P Natl Acad Sci USA 1995; 92:594-598.
Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA. Cloned human neuropeptide Y receptor couples to two different second messenger systems. P Natl Acad Sci USA 1992; 89:5794-5798.
