Professor Roger Daly
Senior Principal Research Fellow; Group Leader, Cancer Research Program, Garvan Institute of Medical Research; NHMRC Principal Research Fellow; Conjoint Professor, Faculty of Medicine, The University of New South Wales
Email: r.daly 'at' garvan.org.au
Research Group: Signal Transduction
This led to an interest in growth factor action, and combined with exciting developments in the signalling field in the late 1980's, drew Roger into the analysis of tyrosine kinase signalling mechanisms. His second postdoc, with Joseph Schlessinger at New York University, led to the cloning and characterisation of Grb2, which established a paradigm for adapter protein signalling. This research resulted in a joint first author Cell paper that has been cited more than 1000 times. Roger’s next move was to the Garvan Institute in 1993. His Signal Transduction Group cloned Grb14 and determined that it is a physiological regulator of insulin action. They have also identified new roles for the cytoskeletal protein cortactin in head and neck cancer, and characterized novel regulatory mechanisms and functions for the Gab2 docking protein. More recently, they have used phosphoproteomic profiling to characterize signalling networks associated with particular cancer subtypes.
1988 PhD University of Liverpool
1984 BSc (Hons) Class I University of Liverpool
Hochgrafe F, Zhang L, O'Toole SA et al. Tyrosine phosphorylation profiling reveals the signalling network characteristics of basal breast cancer cells. Cancer Res: In Press.
Croucher DR, Rickwood D, Tactacan CM et al. Cortactin modulates RhoA activation and expression of Cip/Kip cyclin dependent kinase inhibitors to promote cell cycle progression in 11q13-amplified head and neck squamous cell carcinoma cells. Mol Cell Biol: In Press.
Holt LJ, Lyons RJ, Ryan AS et al. Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis. Mol Endocrinol 2009; 23:1406-1414.
Brummer T, Larance M, Herrera Abreu MT et al. Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. EMBO J 2008; 27:2305-2316.
Bennett HL, Brummer T, Jeanes A et al. Gab2 and Src co-operate in human mammary epithelial cells to promote growth factor independence and disruption of acinar morphogenesis. Oncogene 2008; 27:2693-2704.
Timpson P, Wilson AS, Lehrbach GM et al. Aberrant expression of cortactin in head and neck squamous cell carcinoma cells is associated with enhanced cell proliferation and resistance to the epidermal growth factor receptor inhibitor gefitinib. Cancer Res 2007; 67:9304-9314.
Brummer T, Schramek D, Hayes VM et al. Increased proliferation and altered growth factor dependence of human mammary epithelial cells overexpressing the Gab2 docking protein. J Biol Chem 2006; 281:626-637.
Timpson P, Lynch DK, Schramek D et al. Cortactin overexpression inhibits ligand-induced downregulation of the epidermal growth factor receptor. Cancer Res 2005; 65:3273-3280.
Cooney GJ, Lyons RJ, Crew AJ et al. Improved glucose homeostasis and enhanced insulin signaling in Grb14-deficient mice. EMBO J 2004; 23:582-593.
Lynch DK, Winata SC, Lyons RJ et al. A cortactin/CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. J Biol Chem 2003; 278:21805-21813.