Dr Paul Baldock

Lab Head - Skeletal Metabolism

Senior Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Dr Paul Baldock completed his PhD in Human Physiology at the University of Adelaide in 2001. He joined the Osteoporosis and Bone Biology Division at Garvan and held a postdoctoral position until he was appointed Head of the Skeletal Metabolism Group in 2005. He moved to the Neuroscience Division in 2008 before returning to the Osteoporosis and Bone Biology Division in 2013 to take up his position as an ARC Future Fellow. 

Paul has a sustained record of research excellence, as detailed by prizes from a number of skeletal and general organisations. In 1996, he was awarded the Campion Ma Playoust Prize for Best Researcher under 30 from the Australian Society from Medical Research’s. Between 2004 and 2006 he was awarded a total of 4 Young Investigator Awards from the International (IBMS) and the American (ASBMR) Societies for Bone and Mineral Research. In 2006 he received a Fellowship from the International Human Frontier Science Program, and in 2013 was awarded an ARC Future Fellowship.

Paul has been recognized as one of the fundamental contributors to this rapidly evolving field, being invited to present plenary symposia at the 2 most prestigious bone meetings (IBMS-2008 and ASBMR-2009), as well as invited symposia at broader endocrine meetings in the US (The Pituitary Society), Europe (International Symposium on Endocrinology and Metabolism, International Conference on Children’s Bone Health) and Asia Pacific (Asia Pacific Paediatric Endocrinologist Society). He has been on the Program Organising Committee of international Bone conferences (IBMS), and is currently on the Organising Committee for the Annual meeting of the Australian and New Zealand Bone and Mineral Society and the Australian Endocrine Society. 

He envisages that his research work will redefine the regulatory influences both to and importantly, from bone and contribute to a new generation of therapeutic tools to modulate bone mass, as well as obesity and diabetes.

Research Interests

Bone interactions with energy and glucose metabolism
Neural control of bone mass
Bone feedback to the brain
Murine models of altered bone metabolism
Anabolic therapies for bone mass accrual

Awards and Honours

2013 - Australian Research Council, Future Fellowship
2008 - Australian and New Zealand Bone and Mineral Society, Kaye Ibbertson Award for Bone and Mineral Medicine
2007 - National Health and Medical Reserch Council, Career Development Award
2007 - Australian and New Zealand Bone and Mineral Society/AMGEN, Outstanding Abstract Award, National Annual Scientific Meeting
2006 - International Human Frontier Science Program Organisation, Short-Term International Fellowship, University Hospital Geneva, Switzerland.
2005 - American Society for Bone and Mineral Research, Advances in Mineral Metabolism (Annual Scientific Conference) Young Investigator Award
2004 - American Society for Bone and Mineral Research, Anabolic Agents for the Treatment of Osteoporosis Young Investigator Award
2003 - American Society for Bone and Mineral Research, Young Investigator Award
2002 - American Society for Bone and Mineral Research), Plenary Poster Award, Annual Scientific Conference
2001 - International Bone and Mineral Society, Young Investigator Award
1996 - Australian Society for Medical Research, AMRAD award
1994 - Australian Society for Medical Research, Campion Ma Ploust Award

Education

2001 - PhD, Department of Human Physiology, University of Adelaide - Australia
1992 - BSc (Hons 1), Department of Human Physiology, University of Adelaide - Australia

Selected Publications

Horsnell H, Baldock PA. Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis. Curr Osteoporos Rep. 2016 Feb;14(1):26-31.

Khor EC, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni RN, Enriquez RF, Purtell L, Lee NJ, Wee NK, Croucher PI, Campbell L, Herzog H, Baldock PA. Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PLoS One. 2016 Jan 29;11(1):e0148155.

Khor EC, Yulyaningsih E, Driessler F, Kovaĉić N, Wee NK, Kulkarni RN, Lee NJ, Enriquez RF, Xu J, Zhang L, Herzog H, Baldock PA. The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay. Bone. 2016 Mar;84:139-47.

Wee NK, Kulkarni RN, Horsnell H, Baldock PA. The brain in bone and fuel metabolism. Bone. 2016 Jan;82:56-63.

Houweling P, Kulkarni RN, Baldock PA. Neuronal control of bone and muscle. Bone. 2015 Nov;80:95-100.

Wee NK, Baldock PA. The hunger games of skeletal metabolism. Bonekey Rep. 2014 Nov 12;3:588.

Khor EC, Wee NK, Baldock PA. Influence of hormonal appetite and energy regulators on bone. Curr Osteoporos Rep. 2013 Sep;11(3):194-202.

Wee NK, Kulkarni RN, Horsnell H, Baldock PA. The brain in bone and fuel metabolism. Bone. 2016;82:56-63.

Khor EC, Yulyaningsih E, Driessler F, Kovacic N, Wee NK, Kulkarni RN, Lee NJ, Enriquez RF, Xu J, Zhang L, Herzog H, Baldock PA. The y6 receptor suppresses bone resorption and stimulates bone formation in mice via a suprachiasmatic nucleus relay. Bone. 2016;84:139-47.

Khor EC, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni RN, Enriquez RF, Purtell L, Lee NJ, Wee NK, Croucher PI, Campbell L, Herzog H, Baldock PA. Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome. PloS one. 2016;11:e0148155.

Horsnell H, Baldock PA. Osteoblastic Actions of the Neuropeptide Y System to Regulate Bone and Energy Homeostasis. Current osteoporosis reports. 2016;14:26-31.

Nguyen AD, Lee NJ, Wee NK, Zhang L, Enriquez RF, Khor EC, Nie T, Wu D, Sainsbury A, Baldock PA, Herzog H. Uncoupling protein-1 is protective of bone mass under mild cold stress conditions. Bone. 2015 Jun 6.

Lee NJ, Nguyen AD, Enriquez RF, Luzuriaga J, Bensellam M, Laybutt R, Baldock PA, Herzog H. NPY signalling in early osteoblasts controls glucose homeostasis. Molecular metabolism. 2015;4:164-74.

Lawson MA, McDonald MM, Kovacic N, Hua Khoo W, Terry RL, Down J, Kaplan W, Paton-Hough J, Fellows C, Pettitt JA, Neil Dear T, Van Valckenborgh E, Baldock PA, Rogers MJ, Eaton CL, Vanderkerken K, Pettit AR, Quinn JM, Zannettino AC, Phan TG, Croucher PI. Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche. Nature communications. 2015;6:8983.

Baldock PA, Lin S, Zhang L, Karl T, Shi Y, Driessler F, Zengin A, Hormer B, Lee NJ, Wong IP, Lin EJ, Enriquez RF, Stehrer B, During MJ, Yulyaningsih E, Zolotukhin S, Ruohonen ST, Savontaus E, Sainsbury A, Herzog H. Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2014;29:2238-49.

Sousa DM, McDonald MM, Mikulec K, Peacock L, Herzog H, Lamghari M, Little DG, Baldock PA. Neuropeptide Y modulates fracture healing through Y1 receptor signaling. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2013;31:1570-8.

Shi YC, Lau J, Lin Z, Zhang H, Zhai L, Sperk G, Heilbronn R, Mietzsch M, Weger S, Huang XF, Enriquez RF, Castillo L, Baldock PA, Zhang L, Sainsbury A, Herzog H, Lin S. Arcuate NPY Controls Sympathetic Output and BAT Function via a Relay of Tyrosine Hydroxylase Neurons in the PVN. Cell Metab. 2013; 5:236-48.  

Wong IP, Nguyen AD, Khor EC, Enriquez RF, Eisman JA, Sainsbury A, Herzog H, Baldock PA. Neuropeptide Y is a critical modulator of leptin's regulation of cortical bone. J Bone Miner Res. 2012; 28:886-98.

Wong IPL, Driessler F, Shi Y-C, Hörmer B, Nguyen AD, Enriquez RF, Eisman JA, Sainsbury A, Herbert Herzog H,  Baldock PA. Peptide YY regulates bone remodeling in mice: A link between gut and skeletal biology. PLoS One 2012; 7:e40038.

Sousa DM, Baldock PA, Enriquez RF, Zhang L, Sainsbury A, Lamghari M, Herzog H. Neuropeptide Y Y1 receptor antagonism increases bone mass in mice. Bone 2012; 51:8-16.

Lee NJ, Nguyen AD, Enriquez RF, Doyle KL, Sainsbury A, Herzog H,  Baldock PA. Osteoblast specific Y1 receptor deletion enhances bone mass. Bone. 2011; 48:461-7.

Baldock PA, Lee NJ, Driessler F, Lin S, Allison S, Stehrer B, Lin EJ, Zhang L, Enriquez RF, Wong IP, McDonald MM, During M, Pierroz DD, Slack K, Shi YC, Yulyaningsih E, Aljanova A, Little DG, Ferrari SL, Sainsbury A, Eisman JA, Herzog H. Neuropeptide Y knockout mice reveal a central role of NPY in the coordination of bone mass to bodyweight. PLoS One  2009; 4 :12 e8415.

Igwe JC, Jiang X, Paic F Ma L, Adams DJ, Baldock  PA, Pilbeam C, Kalajzic I. Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity. J Cell Biochem 2009; 108:621-630.

Baldock PA, Allison SJ, Enriquez RF, Lin, EJ, During M, Gardiner, EM, Eisman JA, Sainsbury A, Herzog H. Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis. J Bone Miner Res 2008; 24:294-304.

Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, Bauskin AR, Wu L, Pankhurst G, Jiang L, Junankar S, Hunter M, Fairlie WD, Lee NJ, Enriquez R, Baldock PA, Corey E, Apple FS, Murakami MM, Lin EJ, Wang C, During MJ, Sainsbury A, Herzog H, Breit SN. Tumour-induced anorexia and weight loss is mediated by the TGF-b superfamily cytokine MIC-1. Nat Med 2007; 13:1333-1340.

Baldock PA, Allison SJ, Lundberg P, Lee NJ, Slack K, Lin EJD, Enriquez RF, McDonald MM, Zhang L, During MJ, Little DG, Eisman JA, Gardiner EM, Yulyaningsih E, Lin S, Sainsbury A, Herzog H. Novel role of Y1 Receptors in the Coordinated Regulation of Bone and Energy Homeostasis. J Biol Chem 2007; 282:19092-19102.

Lundberg P, Allison SJ, Lee N, Baldock PA, Brouard N, Rost S, Enriquez R, Sainsbury A, Lamghari M, Simmons P, Eisman JA, Gardiner EM, Herzog H. Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1-receptor expression. J Biol Chem 2007; 282:19082-19091.

Baldock PA, Sainsbury A, Allison S, Lin D, Couzens M, Boey D, Enriquez, RF, Lin S, During M, Herzog H, Gardiner, EM. Hypothalamic control of bone formation: Distinct actions of leptin and Y2 receptor pathways. J Bone Miner Res. 2005; 20:1851-1857.

Baldock PA, Sainsbury A, Schwarzer C, Ueno N, Enriquez RF, Couzens M, Inui A, Herzog H, Gardiner EM. Synergistic Reduction in Adiposity and Increase in Bone Mass in Y2 / Y4 Receptor Double Knockout Mice. Mol Cell Biol, 2003; 23: 5225-5233

Baldock PA, Sainsbury A, Couzens M, Enriquez RF, Thomas GP, Gardiner EM, Herzog H. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002; 109:915-921.

Gardiner EM, Baldock PA, Thomas GP, Sims NA, Henderson NK, Hollis B, White CP, Sunn KL, Morrison NA, Walsh WR, Eisman J. Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage. FASEB J 2000; 14:1908-1916.

Dr Paul Baldock