Dr Georgina Hollway

Visiting Scientist

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Georgina completed a PhD at the Women’s and Children’s Hospital in Adelaide, looking at the genetic basis of human Craniosynostosis syndromes, before moving to MRC Human Genetics Unit in Edinburgh, Scotland to study embryonic development and muscle cell specification in zebrafish. The work using zebrafish as a model organism of human muscle development, and investigation of genetic defects at the molecular level continued at the Victor Chang Cardiac Research Institute, following a move to Sydney.

Having seen that the genetic pathways of normal development are often perturbed in carcinoma, Georgina then wanted to combine an interest in human health with considerable experience in developmental research, particularly the zebrafish system, into a career as a cancer researcher. To this end Georgina started in the Cancer Program at the Garvan Institute in 2009, using zebrafish to study Hedgehog and Sdf1 signalling pathways in carcinoma development and progression.

Research Interests

Embryonic development in zebrafish
Carcinoma development and progression
Muscle fibre specification and development
Hedgehog signalling
Sdf1 signalling
Translational research based on developmental models

Awards and Honours

2011-2013 - CINSW Career Development Fellowship (Cancer Institute, NSW, Australia)
2005-2006 - Freedman Foundation Fellowship (Freedman Foundation, Australia)
2004 - Prize in Paul Korner Seminar Series (VCCRI, Australia)
1999-2000 and 2003 - Howard Florey Fellowship (The Royal Society, UK and NHMRC, Australia)
1997 - Prize in Student Research Presentation Competition (WCH, Australia)
1995-1998 - Australian Postgraduate Award (Australia)
1991 - The Sir Ronald Fisher Prize for Genetics III (The University of Adelaide, Australia)
1990 - The Sir Ronald Fisher Prize for Genetics II (The University of Adelaide, Australia)

Education

1998 - PhD, Faculty of Medicine, University of Adelaide - Australia
1992 - BSc (Hons), University of Adelaide - Australia

Selected Publications

Nguyen PD*, Hollway GE*, Sonntag C, Miles LB, Hall TE, Berger S, Fernandez KJ, Gurevich DB, Cole NJ, Alaei S, Ramialison M, Sutherland RL, Polo JM, Lieschke GJ and Currie PD*. Haematopoietic stem cell induction by somite-derived endothelial cells controlled by meox1.  Nature 2014; 512: 314-318.

Johnson, JLFA, Hall, TE, Dyson, JM, Sonntag, C, Ayers, K, Berger, S, Gautier, P, Mitchell, C, Hollway, GE* and Currie, PD*.  Scube activity is necessary for Hedgehog signal transduction in vivo.  Developmental Biology 2012; 368:193-202.

Hall, TE, Bryson-Richardson, RJ, Berger, S, Jacoby, AS, Cole, NJ, Hollway, GE, Berger, J and Currie, PD.  The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin alpha2-deficient congenital muscular dystrophy.  PNAS USA  2007; 104:7092-7097.

Hollway, GE, Bryson-Richardson, RJ, Berger, S, Jacoby, AS, Cole, NJ, Hall, TE and Currie, PD.  Whole somite rotation generates muscle progenitor cell compartments in the developing zebrafish embryo.  Developmental Cell 2007; 12:207-219.

Svetic, V*, Hollway, G*, Elworthy, S, Chipperfield, T, Davison, C, Adams, R J, Eisen, J S, Ingham, PW, Currie, P and Kelsh, RN. Sdf1a patterns zebrafish melanophores and links the somite and melanophore pattern defects in choker mutants.  Development 2007; 134:1011-1022.

Hollway, GE, Maule J, Gautier P, Evans TM, Keenan DG, Lohs C, Fischer D, Wicking C, Currie PD. Scube2 mediates Hedgehog signalling in the zebrafish embryo.  Developmental Biology 2006; 294:104-118.

Hollway* GE, Currie P. Vertebrate Myotome Development. Birth Defects Research (Part C) 2005; 75:172-179.

Haines L, Neyt C, Gautier P, Keenan DG, Bryson-Richardson RJ, Hollway, GE, Cole NJ and Currie PD. Met and Hgf signalling controls hypaxial muscle and lateral line development in zebrafish.  Development 2004; 131:4857-4869.

Cortés, F, Daggett, D, Bryson-Richardson, R, Neyt, C, Maule, J, Gautier, P, Hollway, G E, Keenan, D and Currie, PD.  Cadherin-mediated differential cell adhesion controls slow muscle cell migration in the developing zebrafish myotome.  Developmental Cell 2003; 5:865-876.

Hollway, G* and Currie, P Myotome meanderings.  Cellular morphogenesis and the making of muscle.  EMBO Reports 2003; 4:855-860.

Kalscheuer, V M, Jiong, T, Donnelly, A, Hollway, G, Schwinger, E, Kubart, S, Menzel, C, Hoeltzenbein, M, Tommerup, N, Eyre, H, Harbord, M, Haan, E, Sutherland, G, Ropers, H-H, and Gecz, J.  Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.  American Journal of Human Genetics 2003; 72:1401-1411.

Gecz, J, Barnett, S, Liu, J, Hollway, G, Donnelly, A, Eyre, H, Eshkevari, H S, Baltazar, R, Grunn, A, Nagaraja, R, Gilliam, C, Peltonen, L, Sutherland G R, Baron, M and Mulley, J C.  Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation.  Genomics 1999; 62:356-368.

Hollway, G E, Suthers, G K, Battese, K M, Turner, A M, David, D J and Mulley, J C. Deafness due to Pro250Arg Mutation of FGFR3. The Lancet 1998; 351:877-878.

Muenke, M, Gripp, K W, McDonald-McGinn, D M, Gaudenz, K, Whitaker, L A, Bartlett, S P, Markowitz, R I, Robin, N H, Nwokoro, N, Mulvihill, J J, Losken, W, Mulliken, J B, Guttmacher, A E, Wilroy, R S, Clarke, L A, Hollway, G E, Ades, L, Haan, E, Mulley, J C, Cohen, M M, Jr, Bellus, G A, Francomano, C A, Moloney, D M, Wall, S A, Wilkie, A O M and Zackai, EH. A unique point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene defines a new syndrome. American Journal of Human Genetics 1997; 60:555-564.

Hollway, G E, Suthers, G K, Haan, E A, Thompson, E, David, D J, Gecz, J and Mulley, JC. Mutation detection in FGFR2 craniosynostosis syndromes. Human Genetics 1997;99: 251-255.

Phillips, H A, Scheffer, I E, Berkovic, S F, Hollway, G E, Sutherland, G R and Mulley, JC. Localisation of a Gene for Autosomal Dominant Nocturnal Frontal Lobe Epilepsy to chromosome 20q13.2. Nature Genetics 1995; 10:117-118.

Hollway, G E, Phillips, H A, Ades, L C, Haan, E A and Mulley, JC. Localisation of Craniosynostosis Adelaide Type to 4p16. Human Molecular Genetics 1995; 4:681-683.

Dr Georgina Hollway