Cancer is a disease of excessive cell division, with cancer cells proliferating uncontrollably, leading to the disruption of normal tissue function and ultimately death. The focus of my research is to understand the molecular mechanisms that regulate and ensure correct DNA replication, repair and cell division utilising cutting edge techniques including phosphoproteomics, mathematical modelling, qualitative multi-dimension live cell imaging and fate mapping, combined with clinical samples and bioinformatics analysis of big data. Through this, my goal is to understand how cancer cells obtain and maintain unstable genomes. This mechanistic information is essential for determining how chromosomal instability contributes to the initiation and evolution of cancer cells. Furthermore, this information will help uncover the mechanisms of innate and acquired resistance, thereby facilitating the personalised use of current therapeutics, and identification of novel treatments, thereby improving clinical practice and patient care.
In the News
Garvan Institute participates in National Science Week Space Oddity event - Aug 25, 2014