Dr Dominique Hess (Gatto)

Manager, Genomic Cancer Medicine

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Dominique received her PhD from the Swiss Federal Institute of Technology in Zurich in 2005 and subsequently moved to Garvan to undertake post-doctoral studies. Her research has focused on investigating basic aspects of the regulation of immune responses in the field of B cell biology and leukocyte migration.

Dominique’s post-doctoral studies led to the identification of the G protein-coupled receptor EBI2 as an essential chemotactic receptor for the generation of immune responses. She continues to pursue her interest in EBI2 and its lipid ligand to improve to the understanding of the role of EBI2 in human health and disease.

Research Interests

Leukocyte migration
Antibody responses
Infectious diseases
Autoimmune disorders

Awards and Honours

2014-2017 - NHMRC Career Development Fellowship
2011-2013 - NHMRC Project Grant
2009 - US Alliance for Lupus Research Pilot grant
2008-2011 - NHMRC Early Career Fellowship
2005 - Swiss Federal Institute of Technology Medal of Distinction for PhD Thesis

Education

2005 - PhD, Swiss Federal Institute of Technology, Zurich - Switzerland
2000 - MSc, Swiss Federal Institute of Technology, Zurich - Switzerland

Selected Publications

Gatto, D., Wood, K., Caminschi, I., Murphy-Durland, D., Schofield, P., Christ, D., Karupiah, G. & Brink, R. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells. Nat. Immunol. 2013; 14:446-453.

Gatto, D. & Brink, R. B cell localization: regulation by EBI2 and its oxysterol ligand. Trends Immunol. 2013; 34:336-342.

Gatto, D., Wood, K. & Brink, R. EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center. J. Immunol. 2011; 187:4621-4628.

Gatto, D. & Brink, R. The germinal center reaction. J. Allergy. Clin. Immunol. 2010; 126:898-907.

Gatto, D., Paus, D., Basten, A., Mackay, C.R. & Brink, R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 2009; 31:259-269.

Chan, T.D., Gatto, D., Wood, K., Camidge, T., Basten, A. & Brink, R. Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. J. Immunol. 2009; 183:3139-3149.

Gatto, D., Martin, S.W., Bessa, J., Pellicioli, E., Saudan, P., Hinton, H.J. & Bachmann, M.F. Regulation of memory antibody levels: the role of persisting antigen versus plasma cell life span. J. Immunol. 2007; 178:67-76.

Gatto, D., Pfister, T., Jegerlehner, A., Martin, S.W., Kopf, M. & Bachmann, M.F. Complement receptors regulate differentiation of bone marrow plasma cell precursors expressing transcription factors Blimp-1 and XBP-1. J. Exp. Med. 2005; 201:993-1005.

Gatto, D. & Bachmann, M.F. Function of marginal zone B cells in antiviral B-cell responses. Crit. Rev. Immunol. 2005; 25:331-342.

Gatto, D., Ruedl, C., Odermatt, B. & Bachmann, M.F. Rapid response of marginal zone B cells to viral particles. J. Immunol. 2004; 173:4308-4316.

Macpherson, A.J., Gatto, D., Sainsbury, E., Harriman, G.R., Hengartner, H. & Zinkernagel, R.M. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 2000; 288:2222-2226.

Dr Dominique Hess (Gatto)