Dr Andreia Pinho

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Andreia was a fellow of the Portuguese graduate program GABBA and carried out her PhD research in the Spanish National Cancer Research Centre in Madrid, Spain, under the supervision of Dr Francisco Real. Her doctoral research project focused on understanding the mechanisms of pancreatic cell differentiation involved in pancreatitis and pancreatic cancer.

Andreia joined the Garvan in 2011, where she is engaged in providing further insights into the molecular mechanisms implicated in the development of pancreatic cancer. Her project’s aim is to uncover the function of novel signalling pathways altered in pancreatic cancer patients, identified through the Australian Pancreatic cancer Genome Initiative (APGI). Her functional studies will determine whether these novel genes have a role in the development or dissemination of the tumour, and consequently could lead to the discovery of new biomarkers for early detection or new therapeutic targets for pancreatic cancer treatment.

Research Interests

Pancreatic ductal adenocarcinoma
Signalling pathways involved in cancer development
Tumour microenvironment
Chronic pancreatitis
Acinar to ductal metaplasia

Awards and Honours

2014-16 - Cancer Institute NSW Early Career Fellowship
2014 and 2015- Hirshberg Award for Best Oral Presentation at the Australasian Pancreatic Club meeting
2014 - Ian Potter Foundation Travel Grant
2013 - EACR Conference on Cancer Genomics Meeting Bursary
2013 - Sydney Catalyst Education and Travel Award
2012 - Abbott/Australasian Pancreatic Club (APC) Travel Grant
2012 - Young Garvan Fellowship from the Garvan Research Foundation
2010 - European Molecular Biology Laboratory Corporate Partnership Programme Fellowship
2006-10 - PhD fellowship from the Portuguese Foundation for Science and Technology (FCT, Portugal)
2005 - Fellow of the GABBA PhD program from the University of Porto, Portugal

Education

2011 - PhD in Biomedicine, University Pompeu Fabra, Barcelona - Spain.
2005 - Degree in Biology (variant Microbiology and Genetics), University of Lisbon - Portugal

Selected Publications

Pinho AV, Bensellam M, Wauters E et al. Pancreas-Specific Sirt1-Deficiency in Mice Compromises Beta-Cell Function without Development of Hyperglycemia. PLoS One 2015 (In Press).

Grimont A, Pinho AV, Cowley MJ et al. SOX9 regulates ERBB signalling in pancreatic cancer development. Gut 2015; 64(11):1790-9.

Waddell N, Pajic M, Patch AM et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 2015; 518(7540):495-501.

Pinho AV, Chantrill L, Rooman I. Chronic pancreatitis: A path to pancreatic cancer. Cancer Lett 2014; 345(2):203-9.

Wauters E, Sanchez-Arévalo Lobo VJ*, Pinho AV* et al. Sirtuin-1 regulates acinar to ductal metaplasia and supports cancer cell viability in pancreatic cancer. Cancer Res 2013; 73(7):2357-2367. *equal contribution

Rooman I, Lutz C, Pinho AV et al. Amino acid transporters expression in acinar cells is changed during acute pancreatitis. Pancreatology 2013; 13(5):475-85.

Biankin AV, Waddell N, Kassahn KS et al. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012; 491(7424):399-405.

Pinho AV, Rooman I, Reichert M et al. Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis. Gut 2011; 60(7):958-66.

Pinho AV, Rooman I, Real FX. p53-dependent regulation of growth, epithelial-mesenchymal transition, and stemness in normal pancreatic epithelial cells. Cell Cycle 2011; 10(8):1312-1321.

Dr Andreia Pinho