Dr Aurelie Cazet

Research Officer

Aurélie graduated with a M.S (Hons I) in Biomedical Sciences and Biotechnology from the University Lille Nord de France in 2007. During her doctoral studies, her research interests included understanding the biology of glycosphingolipids and growth factor receptors in breast cancer progression and aggressiveness.

Her first postdoctoral position at Yale School of Medicine (Department of Therapeutic Radiology) gave her the invaluable opportunity to develop her knowledge in cancer biology and, most importantly, to discover the stimulating world of personalized translational medicine. She is currently undertaking research in the Tumor Progression Group of Dr Alex Swarbrick at the Garvan Institute/Kinghorn Cancer Centre. 

Research Interests

Cellular heterogeneity in the breast tumour microenvironment
Hedgehog signalling
Metastasis
Translational research

Awards and Honours

2010, 2011 - L’Association de la Recherche contre le Cancer Grant (Professor Philippe Delannoy’s laboratory)
2010, 2011 - La Ligue Régionale contre le Cancer Grant (Professor Philippe Delannoy’s laboratory)
2010 - International Mobility Research Fellowship from La Région Nord-Pas de Calais
2008, 2009 - Le Financement Hubert Curien STAR which supported two trips to South Korea during the PhD course (Professor Cheorl-Ho Kim’s laboratory; Molecular and Cellular Glycobiology Unit, Department of Biological Science, SungKyunKwan University, Suwon City, Korea)
2007-2010 - University of Lille Teaching Assistant Fellowship obtained from the University Lille Nord de France, Lille 1, France
2007-2010 - French Government MENRT Postgraduate Research Scholarship supporting stipend during my PhD course
2004 - International Mobility Research Fellowship from CROUS (Centre Régional des oeuvres universitaires et scolaires) Nord-Pas de Calais
2010, 2011 - La Ligue Régionale contre le Cancer Grant for buying consumables and equipments (Professor Philippe Delannoy’s laboratory)
2010 - International Mobility Research Fellowship from La Région Nord-Pas de Calais
2008, 2009 - Le Financement Hubert Curien STAR which supported two trips to South Korea during the PhD course (Professor Cheorl-Ho Kim’s laboratory; Molecular and Cellular Glycobiology Unit, Department of Biological Science, SungKyunKwan University, Suwon City, Korea)
2007-2010 - University of Lille Teaching Assistant Fellowship obtained from the University Lille Nord de France, Lille 1, France
2007-2010 - French Government MENRT Postgraduate Research Scholarship supporting stipend during my PhD course

Education

2010 - PhD, Université Lille Nord de France, Lille 1 - France
2007 - MS 1st Class Honours in Biotechnology, Université Lille Nord de France, Lille 1 - France
2005 - BS 1st Class Honours in Biochemistry, Université Lille Nord de France, Lille 1 - France

Selected Publications

Hui M*, Cazet A*, Nair R, Watkins ND, O’Toole SA, Swarbrick A. The Hedgehog Signalling Pathway in Breast Development, Carcinogenesis and Cancer Therapy. Breast Cancer Research. 2013; 15:203. * These authors contributed equally to this review.

O'Toole SA, Beith JM, Millar EK, West R, McLean A, Cazet A, Swarbrick A, Oakes SR. Therapeutic targets in triple negative breast cancer. J Clin Pathol, 2013; 66:530-42.

Steenackers A, Vanbeselaere J, Cazet A, Bobowski M, Rombouts Y, Le Bourhis X, Guérardel Y, Delannoy P. Accumulation of unusual gangliosides GQ3 and GT3 in breast cancer cells expressing the GD3 synthase. Molecules, 2012; 17:9559-9572.

Cazet A, Bobowski M, Rombouts Y, Lefebvre J, Steenackers A, Popa I, Guérardel Y, Le Bourhis X, Tulasne D, Delannoy P. The ganglioside GD2 induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the GD3 synthase. Glycobiology, 2012; 22:806-816.

Steenackers A*, Cazet A*, Bobowski M, Rombouts Y, Lefebvre L, Guérardel Y, Tulasne D, Le Bourhis X, Delannoy. The expression of GD3 synthase modifies ganglioside profile and increases migration of MCF-7 breast cancer cells. C.R Chimie, 2012; 15:3-14. * These authors contributed equally to this work.

Cazet A, Lefebvre J, Adriaenssens E, Julien S, Bobowski M, Grigoriadis A, Tutt A, Tulasne D, Le Bourhis X and Delannoy P. GD3 synthase expression enhanced proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation. Molecular Cancer Research, 2010; 8:1526-1535.

Cazet A, Julien S, Bobowski M, Burchell J, Delannoy P. The Expression of Tumour-Associated Carbohydrate Antigens in Breast Cancer. Breast Cancer Research. 2010; 12:204-217.

Cazet A, Julien S, Bobowski M, Krzewinski-Recchi MA, Harduin-Lepers A, Groux-Degroote S, Delannoy P. Consequences of the expression of sialylated antigens in breast cancer. Carbohydrate Research. 2010; 345: 1377-1383.

Bernardin A, Cazet A, Guyon L, Delannoy P, Vinet F, Bonnaffé D, Texier I. Copper-free click chemistry for highly luminescent quantum dot conjugates: application to in vivo metabolic imaging. Bioconj. Chem. 2010; 21: 583-588.

Lehoux S, Groux-Degroote S, Cazet A, Dhaenens CM, Maurage CA, Caillet-Boudin ML, Delannoy P, Krzewinski-Recchi MA. Transcriptional regulation of the human ST6GAL2 gene in cerebral cortex and neuronal cells. Glycoconj. J. 2010; 27:99-114.

Trottein F, Schaffer L, Ivanov S, Paget C, Vendeville C, Cazet A, Groux-Degroote S, Lee S, Krzewinski-Recchi MA, Faveeuw C, Head SR, Gosset P, Delannoy P. Glycosyltransferase and sulfotransferase gene expression profiles in human monocytes, dendritic cells and macrophages. Glycoconj J. 2009; 26:1259-1274.

Cazet A, Groux-Degroote S, Teylaert B, Kwon KM, Lehoux S, Slomianny C, Kim CH, Le Bourhis X, Delannoy P. GD3 synthase overexpression enhances proliferation and migration of MDA-MB-231 breast cancer cells. Biol Chem. 2009; 390:601-609.

Groux-Degroote S, Krzewinski-Recchi MA, Cazet A, Vincent A, Lehoux S, Lafitte JJ, Van Seuningen I, Delannoy P. IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewisx epitopes in the human bronchial mucosa. Biochem J. 2008; 410:213-223.

Book chapter:

Bobowski M, Cazet A, Steenackers A, Delannoy P. Role of Complex Gangliosides in Cancer Progression.

Specialist Periodical Reports Carbohydrate Chemistry, 2011, Volume 37.

Dr Aurelie Cazet



Collaborative Program

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