Dr Niantao Deng

Bioinformatician

Research Officer

Niantao Deng obtained his bachelors degree in Applied Mathematics from Shanghai Jiao Tong University in 2006. He then completed his Masters study in statistics and his PhD study in Computation Biology at the National University of Singapore.

He has worked on multiple projects on genetic and epigenetic characterisation of Gastric Cancer using large cohorts of high-throughput microarray and sequencing data. His current interests are to extend the use of statistical methodologies to analyse/integrate large cohorts of breast cancer datasets and help to address some critical questions, such as disease stratification and drug response prediction.

Research Interests

Bioinformatics
Cancer Genomics
Data Mining

Awards and Honours

2013 - Chinese Government Award for Outstanding Self-Financed Students Abroad
2013 - JSPS HOPE Fellow
2012 - Merck Millipore Young Scientist Award 2011 (top10)
2009-2013 - NGS Scholarship, NUS
2006-2008 - Research Scholarship, NUS

Education

2013 - PhD (Computational Biology), National University of Singapore - Singapore
2008 - MSc (Statistics), National University of Singapore - Singapore
2006 - BSc (Applied Mathematics), Shanghai Jiao Tong University - China

Selected Publications

van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger CI, O'Toole SA, Rasko JE, Holst J. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene. 2015 Oct 12. doi: 10.1038/onc.2015.381. [Epub ahead of print]

Cutcutache I, Wu AY, Suzuki Y, McPherson JR, Lei Z, Deng N, Zhang S, Wong WK, Soo KC, Chan WH, Ooi LL, Welsch R, Tan P, Rozen SG. Abundant copy-number loss of CYCLOPS and STOP genes in gastric adenocarcinoma. Gastric Cancer. 2015 Jul 24. [Epub ahead of print]

Phua YW, Nguyen A, Roden DL, Elsworth B, Deng N, Nikolic I, Yang J, Mcfarland A, Russell R, Kaplan W, Cowley MJ, Nair R, Zotenko E, O'Toole S, Tan SX, James DE, Clark SJ, Kouros-Mehr H, Swarbrick A. MicroRNA profiling of the pubertal mouse mammary gland identifies miR-184 as a candidate breast tumour suppressor gene. Breast Cancer Res. 2015 Jun 13;17:83. doi: 10.1186/s13058-015-0593-0.

Das K, Gunasegaran B, Tan IB, Deng N, Lim KH, Tan P. Mutually exclusive FGFR2, HER2 and KRAS gene amplifications in gastric cancer revealed by multicolour FISH. Cancer Lett. 2014 Jul 30. pii: S0304-3835(14)00368-1. doi: 10.1016/j.canlet.2014.07.021. [Epub ahead of print]

Chia NY*, Deng N*, Das K, Huang D, Hu L, Zhu Y, Lim KH, Lee MH, Wu J, Sam XX, Tan GS, Wan WK, Yu W, Gan A, Tan LK, Tay ST, Soo KC, Wong WK, Dominguez LT, Ng HH, Rozen S, Goh LK, Teh BT, Tan P. Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development. Gut. Published Online First: 22 July 2014  doi:10.1136/gutjnl-2013-306596. (*joint first authors)

Muratani M, Deng N, Ooi WF, Lin SJ, Xing M, Xu C, Qamra A, Tay ST, Malik S, Wu J, Lee MH, Zhang S, Tan LL, Chua H, Wong WK, Ong HS, Ooi LL, Chow PK, Chan WH, Soo KC, Goh LK, Rozen S, Teh BT, Yu Q, Ng HH, Tan P. Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. Nat Commun. 2014 Jul 10;5:4361. doi: 10.1038/ncomms5361.

Qian J, Kong X, Deng N, Tan P, Chen H, Wang J, Li Z, Hu Y, Zou W, Xu J, Fang JY. OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer. Gut. 2014 Apr 9. doi: 10.1136/gutjnl-2013-306584. [Epub ahead of print]

Lei Z, Tan IB, Das K, Deng N, Zouridis H, Pattison S, Chua C, Feng Z, Guan YK, Ooi CH, Ivanova T, Zhang S, Lee M, Wu J, Ngo A, Manesh S, Tan E, Teh BT, Yan So JB, Goh LK, Boussioutas A, Hon Lim TK, Flotow H, Tan P, Rozen SG. Identification of Molecular Subtypes of Gastric Cancer with Different Responses to PI3-Kinase Inhibitors and 5-Fluorouracil.
 Gastroenterology. 2013 Sep;145(3):554-65.

Nagarajan N, Bertrand D, Hillmer AM, Zang ZJ, Yao F, Jacques PE, Teo AS, Cutcutache I, Zhang Z, Lee WH, Sia YY, Gao S, Ariyaratne PN, Ho A, Woo XY, Veeravali L, Ong CK, Deng N, Desai KV, Khor CC, Hibberd ML, Shahab A, Rao J, Wu M, Teh M, Zhu F, Chin SY, Pang B, So JB, Bourque G, Soong R, Sung WK, Teh BT, Rozen S, Ruan X, Yeoh KG, Tan PB, Ruan Y. Whole-genome reconstruction and mutational signatures in gastric cancer.
 Genome Biol. 2012 Dec 13;13(12):R115. [Epub ahead of print]

Zouridis H*, Deng N*, Ivanova T, Zhu Y, Wong B, Huang D, Wu YH, Wu Y, Tan IB, Liem N, Gopalakrishnan V, Luo Q, Wu J, Lee M, Yong WP, Goh LK, Teh BT, Rozen S, Tan P.  Molecular Subtypes and Large Scale Epigenetic Alterations in Gastric Cancer Revealed by Genomic Methylome Profiling
. Sci Transl Med. 2012 Oct 17;4(156):156ra140. (*joint first authors)

Zang ZJ, Cutcutache I, Poon SL, Zhang SL, McPherson JR, Tao J, Rajasegaran V, Heng HL, Deng N, Gan A, Lim KH, Ong CK, Huang D, Chin SY, Tan IB, Ng CC, Yu W, Wu Y, Lee M, Wu J, Poh D, Wan WK, Rha SY, So J, Salto-Tellez M, Yeoh KG, Wong WK, Zhu YJ, Futreal PA, Pang B, Ruan Y, Hillmer AM, Bertrand D, Nagarajan N, Rozen S, Teh BT, Tan P. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
 Nat Genet. 2012;44(5):570-4.

Deng N*, Goh LK*, Wang H, Das K, Tao J, Tan IB, Zhang S, Lee M, Wu J, Lim KH, Lei Z, Goh G, Lim QY, Tan AL, Sin Poh DY, Riahi S, Bell S, Shi MM, Linnartz R, Zhu F, Yeoh KG, Toh HC, Yong WP, Cheong HC, Rha SY, Boussioutas A, Grabsch H, Rozen S, Tan P. A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. Gut. 2012 May;61(5):673-84. Epub 2012 Feb 7. (*joint first authors)

Yan B, Yau EX, Samanta S, Ong CW, Yong KJ, Ng LK, Bhattacharya B, Lim KH, Soong R, Yeoh KG, Deng N, Tan P, Lam Y, Salto-Tellez M; Singapore Gastric Cancer Consortium. Clinical and therapeutic relevance of PIM1 kinase in gastric cancer.
 Gastric Cancer. 2012 Apr;15(2):188-97. Epub 2011 Oct 13.

Tan IB, Ivanova T, Lim KH, Ong CW, Deng N, Lee J, Tan SH, Wu J, Lee MH, Ooi CH, Rha SY, Wong WK, Boussioutas A, Yeoh KG, So J, Yong WP, Tsuburaya A, Grabsch H, Toh HC, Rozen S, Cheong JH, Noh SH, Wan WK, Ajani JA, Lee JS, Tellez MS, Tan P. Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy.
 Gastroenterology. 2011 Aug;141(2):476-85, 485.e1-11. Epub 2011 Apr 28.

Tao J, Deng NT, Ramnarayanan K, Huang B, Oh HK, Leong SH, Lim SS, Tan IB, Ooi CH, Wu J, Lee M, Zhang S, Rha SY, Chung HC, Smoot DT, Ashktorab H, Kon OL, Cacheux V, Yap C, Palanisamy N, Tan P. CD44-SLC1A2 gene fusions in gastric cancer.
 Sci Transl Med. 2011 Apr 6;3(77):77ra30.

Oh HK, Tan AL, Das K, Ooi CH, Deng NT, Tan IB, Beillard E, Lee J, Ramnarayanan K, Rha SY, Palanisamy N, Voorhoeve PM, Tan P. Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.
 Clin Cancer Res. 2011 May 1;17(9):2657-67. Epub 2011 Mar 17. 

Dr Niantao Deng



Collaborative Program

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