Dr Claire Edwards

ProMis Team Member Profile

Claire-EdwardsDr Claire Edwards, BSc, PhD

University Lecturer in Bone Oncology,

University of Oxford

Full research profile

 

 

Dr Edwards graduated from the University of Sheffield with a first class honours degree in Pharmacology in 1995. Her interest in bone oncology began with her PhD studies, and she completed a PhD at theUniversity of Sheffield in 1999. She undertook postdoctoral studies at the University of Sheffield and the University of Oxford. Dr Edwards then relocated to the University of Texas Health Science Centre at San Antonio, and subsequentlyVanderbilt University to work with the late Prof Gregory Mundy as an Assistant Professor. In 2010, she was recruited to the University of Oxford, where she is currently a University Lecturer in Bone Oncology.

Dr Edwards’ research is centred around the cellular and molecular mechanisms that mediate tumour growth within bone and the development of cancer-induced bone disease, with a particular focus on multiple myeloma and prostate cancer bone metastases. Dr Edwards’ early research investigated the role of anti-resorptive drugs such as bisphosphonates, and signalling mechanisms including the RANKL and Wnt signalling pathways. More recently, she has concentrated on the contributions from the host microenvironment, and has developed a murine model enabling the molecular investigation of the host microenvironment in vivo. Her studies have revealed novel roles for bone marrow stromal cells and adipokines in the pathogenesis of cancer-induced bone disease.

Dr Edwards is the recipient of a number of awards, including the European Calcified Tissue Society Iain T. Boyle Award, designed to acknowledge the contributions of the recipient to bone biology. Her research is currently funded by the National Institute of Health/ National Cancer Institute, Leukaemia and Lymphoma Research, the Kay Kendall Leukaemia Foundation and the European Union.