Diabetes and Metabolism
The goal of the Diabetes and Metabolism Division is to better understand how genes and the environment interact in the emergence of human disease, particularly diabetes and obesity. The obesity epidemic is having an enormous impact on the health and economies of developed and developing countries and there is a desperate need to understand how alterations in the diet and lifestyle have triggered this rapid increase in obesity, diabetes and other diseases such as cardiovascular disease, dementia and cancer.
The Division investigates the control of insulin production and secretion, and its disruption in type 2 diabetes. Potential mechanisms of beta cell failure and strategies for beta cell survival and regeneration are also being studied. We have researchers mapping the insulin action pathway using mass spectrometry and developing systems biology approaches (genomics, proteomics, metabolomics) to study the aetiology and pathology of metabolic disease. Defining the interplay between energy metabolism and signal transduction and understanding the relationship between food intake and insulin resistance in humans are also under investigation in our Division. The complexities of fat tissue metabolism and its role in energy storage (white fat) and energy production (brown fat) is being investigation at both a basic science and a clinical level.
The Garvan Mass Spectrometry facility has been established within the Diabetes and Metabolism Division.
- Adipose Tissue Biology in Diabetes and Obesity (Lab Head: Prof Katherine Samaras)
- Beta Cell Regeneration (Lab Head: Dr Daniel Hesselson)
- Beta Cell Signalling (Lab Head: Prof Trevor Biden)
- Cellular Systems Biology (Lab Head: Prof David James)
- Clinical Diabetes, Appetite and Metabolism (Lab Heads: Prof Lesley Campbell and A/Prof Jerry Greenfield)
- Molecular Metabolism (Lab Head: Prof Greg Cooney)
- Insulin Signalling (Lab Head: Dr Carsten Schmitz-Peiffer)
- Islet Biology (Lab Head: A/Prof Ross Laybutt)
- Phospholipid and Cell Biology (Lab Head: Dr William Hughes)