Diabetes and Metabolism
The overarching goal of the Diabetes and Metabolism Division is to understand the relationship between changes in the environment and the emergence of human disease. The obesity epidemic is having an enormous impact on world health and economies and there is a desperate need to understand how alterations in the diet and lifestyle have triggered this rapid onslaught of metabolic diseases.
Specific interests include: control of insulin secretion and its disruption in type 2 diabetes; mapping the insulin action pathway using mass spectrometry; developing systems biology approaches (genomics, proteomics, metabolomics) to study the aetiology and pathology of metabolic disease; defining the intersection between fuel metabolism and signal transduction; understanding the relationship between food intake and insulin resistance in humans; dissecting nutrient partitioning pathways in mammals in relation to whole body adiposity; establishing the importance of mitochondria in regulating insulin resistance; beta cell biology (regeneration, trans-differentiation, survival).
The Garvan Mass Spectrometry facility has been established within the Diabetes and Metabolism Division.
- Adipose Tissue Biology in Diabetes and Obesity (Lab Head: Prof Katherine Samaras)
- Appetite and Adiposity in Type 2 Diabetes and Prader Willi Syndrome (Lab Head: Prof Lesley Campbell)
- Beta Cell Regeneration (Lab Head: Dr Daniel Hesselson)
- Beta Cell Signalling (Lab Head: Prof Trevor Biden)
- Cellular Systems Biology (Lab Head: Prof David James)
- Clinical Diabetes and Metabolism (Lab Head: A/Prof Jerry Greenfield)
- Molecular Metabolism (Lab Head: Prof Greg Cooney)
- Insulin Signalling (Lab Head: Dr Carsten Schmitz-Peiffer)
- Islet Biology (Lab Head: A/Prof Ross Laybutt)
- Phospholipid and Cell Biology (Lab Head: Dr William Hughes)