Dr Daniel Hesselson

Lab Head - Beta Cell Regeneration

Conjoint/Adjunct Role(s)

Conjoint Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Daniel established his lab at the Garvan in 2012 following postdoctoral training with Didier Stainier at UCSF. His group is exploiting the experimental advantages of the zebrafish model system to develop new approaches for tackling the growing diabetes epidemic.

Research Interests

Pancreas development and regeneration
In vivo drug screening

Awards and Honours

2010 - Juvenile Diabetes Research Foundation Advanced Postdoctoral Fellowship
2007 - Larry L. Hillblom Postdoctoral Fellowship
2003 - CIHR Doctoral Research Award

Education

2006 - PhD in Genetics, University of Wisconsin – Madison - USA
2001 - BSc (Honors) in Molecular Genetics, University of Alberta - Canada

Selected Publications

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST (2015) Nuclear factor kappaB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity. J Exp Med. Jun 29 Released with Commentary: http://jem.rupress.org/content/212/8/1140.2?etoc

Ye L, Robertson MA, Hesselson D, Stainier DY, Anderson RM (2015) Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis. Development 142(8),1407-17.

Anderson RM, Delous M, Bosch JA, Lihua Y, Robertson MA, Hesselson D, Stainier D (2013) Hepatocyte Growth Factor signaling in intrapancreatic ductal cells drives pancreatic morphogenesis. PLOS Genetics 9(7), e1003650.

Ninov N, Hesselson D, Gut, P, Zhou A, Fidelin, K, Stainier, DYR (2013) Metabolic regulation of cellular plasticity in the pancreas. Current Biology 23(13), 1242-50.

Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. (2013) Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nature Chemical Biology 9, 97-104

Ni TT, Lu J, Zhu M, Maddison LA, Boyd KL, Huskey L, Ju B, Hesselson D, Zhong TP, Page-McCaw PS, Stainier DY, Chen W. (2012) Conditional control of gene function by an invertible gene trap in zebrafish. PNAS 109(38), 15389-94.

Hesselson D, Anderson RM, Stainier DYR. (2011) Suppression of Ptf1a induces acinar-to-endocrine conversion. Current Biology 21, 712-717.

Anderson RM, Bosch JA, Goll MG, Hesselson D, Dong PDS, Shin D, Chi NC, Shin CH, Schlegel A, Halpern M, Stainier DYR. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology 334(1), 213-223.

Hesselson D, Anderson RM, Beinat M, Stainier DYR. (2009) Distinct populations of quiescent and proliferative pancreatic β-cells identified by HOTcre mediated labeling. PNAS 106(35), 14896-14901.

Hesselson D and Kimble J. (2006) Growth control by EGF-repeats of the C. elegans Fibulin-1C isoform. Journal of Cell Biology 175, 217-223.

Hesselson D, Newman C, Kim KW, Kimble J. (2004) GON-1 and Fibulin have antagonistic roles in control of organ shape. Current Biology 14, 2005-2010

Dr Daniel Hesselson