Dr Maria Findeisen

Research Officer

Born in Leipzig, Germany, I finished my Prediploma in Molecular Medicine/Biochemistry (Friedrich-Schiller-University, Jena) followed by an undergraduate degree at Leipzig University. During this time I participated in the international exchange program ERASMUS (Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland) and belonged to the Clinical Research Unit 152 (Atherobesity) where I investigated Adiponectin and its interaction with AdipoR1/2.

Later on, my PhD thesis (Faculty of Biosciences, Pharmacy and Psychology, Leipzig University) aimed to disclose subtype-selective mechanisms within the NPY-related receptor family of Neuropeptide FF. At that time I was a member of the Integrated Research Training Group "Protein Science" and successfully participated and qualified in a three-year graduate program.

After finishing my PhD thesis, I travelled through Australia before undertaking my first post-doctoral studies in the Atherothrombosis and Vascular Laboratory at the Baker IDI Heart and Diabetes Institute in Melbourne, in 2013, where I investigated the pro- and anti-inflammatory properties of C-reactive protein (CRP). Here I focused on CRP mutants and their interaction with recombinant β-sheet aggregates to establish the role of CRP in protein misfolding disorders.

In 2015, I started a post-doctoral position under the guidance of Prof Mark Febbraio within the project “Targeting gp130 to prevent inflammation and promote insulin action” which will allow me to investigate the chimeric designer cytokine IC7 and its efficacy as a treatment strategy for obesity-induced insulin resistance and for type 2 diabetes.

Throughout my career I have been fascinated with biologically interesting protein interactions in various complexes and have now applied my knowledge and skills to metabolism. Specifically, this post-doctoral position will allow me to expand my training in pre-clinical animal models aiming at identifying and understanding molecular pathways.

Research Interests

Obesity
Insulin Resistance
Cytokines
Multiligand / Multireceptor Systems
Mouse Models

Awards and Honours

2009-2012 - Certified Member of the Graduate Program “Protein Science”
2007 - ERASMUS Grant, International Exchange Program

Education

2012 - PhD (Dr rer nat), Institute of Biochemistry, Leipzig University - Germany
2008 - Diploma in Biochemistry (eq MSc), Institute of Biochemistry, Leipzig University - Germany
2005 - Prediploma in Molecular Medicine/Biochemistry (eq BSc), Institute for Biochemistry and Biophysics, Friedrich-Schiller-University Jena - Germany

Selected Publications

Findeisen M*, Würker C*, Rathmann D, Meier R, Meiler J, Olsson R and Beck-Sickinger A.G. (2012). Selective Mode of Action of Guanidine Containing Non Peptides at Human Neuropeptide FF Receptors. J Med Chem. 55(13):6124-6136

Findeisen M*, Rathmann D* and Beck-Sickinger A.G. (2011). RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential. Pharmaceuticals. 4(9):1248-1280

Findeisen M*, Rathmann D* and Beck-Sickinger A.G. (2011). Structure-Activity Studies of RFamide Peptides Reveal Subtype-Selective Activation of Neuropeptide FF1 and FF2 Receptors. ChemMedChem. 6(6):1081-1093

Dr Maria Findeisen