Dr Dorit Samocha-Bonet

Group Leader - Clinical Insulin Resistance

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, School of Medical Sciences, UNSW Australia

After completing a BSc degree in Nutritional Sciences at the Hebrew University (Israel) in 1992, Samocha-Bonet joined the Nutrition and Dietetics Department at Tel Aviv Medical Centre as a clinical dietician. In 1996 she completed a MSc in Clinical Biochemistry at Tel Aviv University (Israel).

As a clinical dietician, Samocha-Bonet came to terms with the fact that only a minority of her patients could maintain a reduced healthy weight in the long term and she decided to turn to research into obesity and metabolic disease. After the birth of her second child, she embarked on a PhD in medical science.

After completing a PhD in Physiology and Pharmacology at Tel Aviv University (Israel, 2006), she relocated to Sydney where she took a postdoctoral position at the Diabetes & Metabolism Division at the Garvan Institute of Medical Research. In 2011 she was awarded the Skip Martin Early Career Fellowship from the Australian Diabetes Society.

In 2013, she established the Clinical Insulin Resistance group at the Garvan Institute.

Research Interests

Insulin resistance
Metabolic disease
Metabolically-healthy obese
Adiposity
Glutamine effect on glucagon-like peptide-1 secretion

Awards and Honours

2011 - Skip Martin Early Career Fellow, Australian Diabetes Society

Education

2006 - PhD, Sackler School of Medicine, Tel Aviv University - Israel
1996 - MSc, Sackler School of Medicine, Tel Aviv University - Israel
1993 - RD (Registered Dietician), Israeli Ministry of Health Department of Medical Professions
1992 - BSc, Hebrew University - Israel

Selected Publications

Tonks KT, Coster ACF, Christopher MJ, Chaudhuri R, Xu A, Gagnon-Bartsch J, Chisholm DJ, James DE, Meikle PJ, Greenfield JR, Samocha-Bonet D. Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Obesity 2016; 24: 908-916.

Williams RS, Kozan P, Samocha-Bonet D The role of dietary acid load and mild metabolic acidosis in insulin resistance in humans. Biochimie 2015 Sep 10. pii: S0300-9084(15)00287-4. doi: 10.1016/j.biochi.2015.09.012. [Epub ahead of print]

Chen DL, Liess C, Poljak A, Xu A, Zhang J, Thoma C, Trenell M, Milner B, Jenkins AB, Chisholm DJ, *Samocha-Bonet D, *Greenfield JR Phenotypic characterization of insulin-resistant and insulin-sensitive obesity. J Clin Endocrinol Metab 2015 Sep 17:jc20152712. [Epub ahead of print]

Williams RS, Heilbronn LK, Chen DL, Coster AC, Greenfield JR, Samocha-Bonet D Dietary acid load, metabolic acidosis and insulin resistance - lessons from cross-sectional and overfeeding studies in humans. Clin Nutr 2015 Aug 12. pii: S0261-5614(15)00218-6. doi: 10.1016/j.clnu.2015.08.002. [Epub ahead of print]

Samocha-Bonet D, Chisholm DJ, Holst JJ, Greenfield JR L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like peptide-1 in type 2 diabetes patients. Nutrients 2015 7(4):2101-8

Samocha-Bonet D, Chisholm DJ, Gribble FM, Coster AC, Carpenter KH, Jones GR, Holst JJ, Greenfield JR Glycemic Effects and Safety of L-Glutamine Supplementation with or without Sitagliptin in Type 2 Diabetes Patients-A Randomized Study. PLoS One 2014 9(11):e113366.

Samocha-Bonet D, Dixit VD, Kahn CR, Leibel RL, Lin X, Nieuwdorp M, Pietiläinen, KH, Rabasa-Lhoret R, Roden M, Scherer PE, Klein S, Ravussin E Metabolically healthy and unhealthy obese - the 2013 Stock Conference report. Obes Rev 2014 15(9):697-708. doi: 10.1111/obr.12199.

Wu LE, Samocha-Bonet D, Whitworth T, Fazakerley DJ, Turner N, Biden TJ, James DE, Cantley J  Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity. Mol Metab 2014 14;3(4):465-73. 

Samocha-Bonet D, Tam CS, Campbell LV, Heilbronn LK Raised circulating fetuin-A after 28-day overfeeding in healthy humans Diabetes Care 2014 37(1): e15-6.

Heilbronn LK, Coster ACF, Campbell LV, Greenfield JR, Lange K, Christopher MJ, Meikle PJ, Samocha-Bonet D The effect of short term overfeeding on serum lipids in healthy humans. Obesity 2013 Dec;21(12):E649-59. doi: 10.1002/oby

Heilbronn LK, Campbell LV, Xu A, Samocha-Bonet D Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans. PLoS One 2013 8(10):e78864

Hocking S, Samocha-Bonet D, Milner K-L, Greenfield JR, Chisholm DJ Adiposity and Insulin Resistance in Humans: The Role of the Different Tissue and Cellular Lipid Depots. Endo Rev 2013 34:463-500

Samocha-Bonet D, Chisholm DJ, Tonks K, Campbell LV, Greenfield JR Insulin-sensitive obesity in humans - a 'favorable fat' phenotype? Trends Endocrinol Metab 2012 23:116-124

Samocha-Bonet D, Campbell LV, Mori TA, Croft KD, Greenfield JR, Turner N, Heilbronn LK Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PLoS One 2012 7:e36320

Samocha-Bonet D, Wong O, Synnott EL, Piyaratna N, Douglas A, Gribble FM, Holst JJ, Chisholm DJ, Greenfield JR Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients. J Nutr 2011 141:1233-1238

Tam CS, Viardot A, Clement K, Tordjman J, Tonks K, Greenfield JR, Campbell LV, Samocha-Bonet D, Heilbronn LK Short-term overfeeding may induce peripheral insulin resistance without altering subcutaneous adipose tissue macrophages in humans. Diabetes 2010 59:2164-2170

Samocha-Bonet D, Heilbronn LK, Lichtenberg D, Campbell LV Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals? Trends Endocrinol Metab 2010 21 (2):83-87

Samocha-Bonet D, Campbell LV, Viardot A, Freund J, Tam CS, Greenfield JR, Heilbronn LK A family history of type 2 diabetes increases risk factors associated with overfeeding. Diabetologia 2010 53:1700-1708

Assayag EB, Bornstein N, Shapira I, Mardi T, Goldin Y, Tolshinski T, Vered Y, Zakuth V, Burke M, Berliner S, Samocha-Bonet D Inflammation-sensitive proteins and erythrocyte aggregation in atherothrombosis. Int J Cardiol 2005 98:271-276

Samocha-Bonet D, Gal S, Schnitzer E, Lichtenberg D, Pinchuk I Lipid peroxidation in the presence of albumin, inhibitory and prooxidative effects. Free Radic Res 2004 38:1173-1181

Samocha-Bonet D, Ben-Ami R, Shapira I, Shenkerman G, Abu-Abeid S, Stern N, Mardi T, Tulchinski T, Deutsch V, Yedgar S, Barshtein G, Berliner S Flow-resistant red blood cell aggregation in morbid obesity. Int J Obes Relat Metab Disord 2004 28:1528-1534

Samocha-Bonet D, Lichtenberg D, Tomer A, Deutsch V, Mardi T, Goldin Y, Abu-Abeid S, Shenkerman G, Patshornik H, Shapira I, Berliner S Enhanced erythrocyte adhesiveness/aggregation in obesity corresponds to low-grade inflammation. Obes Res 2003 11:403-407

Dr Dorit Samocha-Bonet