Prof Gregory Cooney

Prof Gregory Cooney

Lab Head - Insulin Action and Energy Metabolism

Senior Principal Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Professor, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Greg Cooney completed his PhD at the Department of Biochemistry, University of Sydney in 1980 and from 1980 to 1984 worked as a Departmental Demonstrator in the Department of Biochemistry at the University of Oxford, UK. There he developed an interest in the role of thermogenic brown adipose tissue in energy balance and the development of obesity. Greg returned to Sydney in 1985 to work in the Department of Endocrinology, Royal Prince Alfred Hospital on the biochemical mechanisms involved in the development of obesity and insulin resistance.

He joined the Diabetes Group at the Garvan Institute in 1997 to continue examination of the links between obesity, insulin resistance and type 2 diabetes. Greg is an NHMRC Senior Research Fellow and Conjoint Professor at the University of New South Wales. He is an author on more that 140 original papers and review articles in peer-reviewed journals dealing with mechanisms of obesity-induced insulin resistance. He has been a Senior Editor for the Journal of Endocrinology, has served as an Associate Editor and on the Advisory Board of the journal Diabetologia and is a member of the Editorial Board of Diabetes and the American Journal of Physiology – Endocrinology and Metabolism.

Greg has served on the Council of the Australasian Society for the Study of Obesity acting as Honorary Treasurer of the Society.  He has also been a councillor, Treasurer and Vice President of the Australian Diabetes Society.

Research Interests

Obesity and insulin action
Glucose and fat metabolism
Muscle metabolism
Circadian rhythms and metabolism

Awards and Honours

NHMRC Senior Research Fellow
1980 - Eleanor Sophia Wood Travelling Fellowship
1975 - Roslyn Flora Goulston Prize for Biochemistry

Education

1980 - PhD, University of Sydney - Australia
1976 - BSc (Hons I), University of Sydney - Australia

Selected Publications

Hocking SL, Stewart RL, Brandon AE, Suryana E, Stuart E, Baldwin EM, Kolumam GA, Modrusan Z, Junutula JR, Gunton JE, Medynskyj M, Blaber SP, Karsten E, Herbert BR, James DE, Cooney GJ, Swarbrick MM.  Subcutaneous fat transplantation alleviates diet-induced glucose intolerance and inflammation in mice.  Diabetologia. 2015 Apr 22. [Epub ahead of print].

Brandon AE, Tid-Ang J, Wright LE, Stuart E, Suryana E, Bentley N, Turner N, Cooney GJ, Ruderman NB, Kraegen EW.  Overexpression of SIRT1 in rat skeletal muscle does not alter glucose induced insulin resistance.  PLoS One. 2015; 10 (3):e0121959 (eCollection).

Stöckli J, Meoli CC, Hoffman NJ, Fazakerley DJ, Pant H, Cleasby ME, Ma X, Kleinert M, Brandon AE, Lopez JA, Cooney GJ, James DE.  The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle.  Diabetes. 2015; 64 (6):1914-22.

Liu M, Montgomery MK, Fiveash CE, Osborne B, Cooney GJ, Bell-Anderson K, Turner N.  PPARα-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis.  Sci Rep. 2014; 4:5538.

Wu LE, Meoli CC, Mangiafico SP, Fazakerley DJ, Cogger VC, Mohamad M, Pant H, Kang MJ, Powter E, Burchfield JG, Xirouchaki CE, Mikolaizak AS, Stöckli J, Kolumam G, van Bruggen N, Gamble JR, Le Couteur DG, Cooney GJ, Andrikopoulos S, James DE.  Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction.  Diabetes. 2014; 63 (8):2656-67.

Mokbel N, Hoffman NJ, Girgis CM, Small L, Turner N, Daly RJ, Cooney GJ, Holt LJ.  Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation.  J Cell Physiol. 2014; 229 (11):1753-64.

Solon-Biet SM, McMahon AC, Ballard JW, Ruohonen K, Wu LE, Cogger VC, Warren A, Huang X, Pichaud N, Melvin RG, Gokarn R, Khalil M, Turner N, Cooney GJ, Sinclair DA, Raubenheimer D, Le Couteur DG, Simpson SJ.  The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.  Cell Metab. 2014; 19 (3):418-30.

Turner N, Cooney GJ, Kraegen EW, Bruce CR. Fatty acid metabolism, energy expenditure and insulin resistance in muscle.  J Endocrinol. 2014; 220 (2):T61-79.  Review.

Turner N, Kowalski GM, Leslie SJ, Risis S, Yang C, Lee-Young RS, Babb JR, Meikle PJ, Lancaster GI, Henstridge DC, White PJ, Kraegen EW, Marette A, Cooney GJ, Febbraio MA, Bruce CR. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia. 2013; 56 (7): 1638-48.

Prof Gregory Cooney