Dr Fabian Buske

Visiting Scientist

Fabian completed his Bachelor and Master of Science at  Freie Universität Berlin, Germany, before starting his PhD on nucleic acid triple helices at the Institute for Molecular Bioscience in Brisbane, Australia, graduating in 2013.

He then joined the Cancer Epigenetics lab at the Garvan Institute and accepted the challenge of integrating the wide array of epigenetic data sets as well as to extend our predominately one-dimensional view of genomic data to the third dimension to unravel the cellular mechanisms that contribute to cancer.

Fabian specialises in machine learning and graph-based data analysis of large sequence, epigenomic, transcriptomic and medical data sets and is tapping into state-of-the-art Big Data technology to advance our understanding of cancer biology.

Research Interests

The genome’s three-dimensional organisation in normal and cancer biology
Data processing and analytics of large scale sequencing data using HPC cluster
Sequence Analysis, Machine Learning and Data Mining of genomic, transcriptomic and epigenomic data in normal and cancer biology
Graph-based data representation, analysis and visualization of Big Data

Education

2013 - PhD (Bioinformatics), Institute for Molecular Bioscience, University of Queensland - Australia
2007 - MSc (Major: Bioinformatics), Freie Universität Berlin - Germany
2005 - BSc (Major: Bioinformatics), Freie Universität Berlin - Germany

Selected Publications

Fabian A. Buske, Hugh J. French, Martin A. Smith, Susan J. Clark and Denis C. Bauer. NGSANE: A Lightweight Production Informatics Framework for High Throughput Data Analysis. Bioinformatics, 2014: 10.1093/bioinformatics/btu036.

Fabian A. Buske, Denis C. Bauer, John S. Mattick, Timothy L. Bailey. Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci. Bioinformatics, 2013: doi: 10.1093/bioinformatics/btt315 

Fabian A. Buske, Denis C. Bauer, John S. Mattick, Timothy L. Bailey. Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci. Genome Research, 2012: doi:10.1101/gr.130237.111

Fabian A. Buske, John S. Mattick, Timothy L. Bailey, Potential in vivo roles of nucleic acid triple-helices. RNA biology, 2011, doi: 10.4161/rna.8.3.14999

Fabian A. Buske, Mikael Bodén, Denis C Bauer, Timothy L. Bailey, Assigning roles to DNA regulatory motifs using comparative genomics. Bioinformatics, 2010, doi:10.1093/bioinformatics/btq049

Timothy L Bailey, Mikael Boden, Fabian A Buske, Martin Frith, Charles E Grant, Luca Clementi, Jingyuan Ren, Wilfred W Li, William S Noble, MEME SUITE: tools for motif discovery and searching. Nucl. Acids Res, 2009, doi: 10.1093/nar/gkp335

Dr Fabian Buske



Division Overview

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