Dr Michael Clark

Research Officer

EMBO Long Term Research Fellow

Mike completed his BSc (Hons) and MSc at the University of Otago in New Zealand, before joining the lab of Prof John Mattick for his PhD to study long noncoding RNAs. He joined A/Prof Marcel Dinger’s lab in 2013 and is currently based in the MRC Functional Genomics Unit at the University of Oxford.

Mike’s research focuses on gene expression, especially of long noncoding RNAs and how these and other noncoding parts of our genome are regulated and can contribute to disease.

Research Interests

Transcriptomics
Genomics
Gene expression and epigenetics
Long noncoding RNAs
Neurological disorders

Awards and Honours

2014-2017 - NHMRC CJ Martin Overseas Biomedical Fellowship
2014-2016 - EMBO Long Term Fellowship
2013 - Australian RNA Special Interest Group Young Investigator Award
2013 - Dean's Award for Research Higher Degree Excellence

Education

2012 - PhD, University of Queensland - Australia
2009 - MSc, University of Otago - New Zealand
2006 - BSc Hons (1st Class), University of Otago - New Zealand

Selected Publications

Mercer TR*, Clark MB*, Andersen SB, Brunck ME, Haerty W, Crawford J, Taft RJ, Nielsen LK, Dinger ME, Mattick JS (2015). Genome-wide discovery of human splicing branchpoints. Genome Res. January 5, doi: 10.1101/gr.182899.114

Quek XC, Thomson DW, Maag JL, Bartonicek N, Signal B, Clark MB, Gloss BS, Dinger ME (2014). lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs. Nucleic Acids Res. Oct 20. doi: 10.1093/nar/gku988 

Mercer TR*, Clark MB*, Crawford J*, Brunck ME, Gerhardt DJ, Taft RJ, Nielsen LK, Dinger ME, Mattick JS (2014). Targeted sequencing for gene discovery and quantification using RNA CaptureSeq. Nat Protoc. 9: 989-1009 

Mercer TR, Edwards SL, Clark MB, Neph SJ, Wang H, Stergachis AB, John S, Sandstrom R, Li G, Sandhu KS, Ruan Y, Nielsen L, Mattick JS, Stamatoyannopoulos JA (2013). DNaseI-hypersensitive exons co-localize with promoters and distal regulatory elements. Nat Genet. 45: 852-9 

Clark MB, Choudhary A, Smith, MA, Taft RJ, Mattick JS (2013). The dark matter rises: The expanding world of regulatory RNAs. Essays Biochem. 54: 1–16

Clark MB, Johnston RL, Inostroza-Ponta M, Fox AH, Fortini E, Moscato P, Dinger ME, Mattick JS (2012). Genome-wide analysis of long noncoding RNA stability. Genome Res. 22: 885-898 

Clark MB, Amaral PP, Schlesinger FJ, Dinger ME, Taft RJ, et al. (2011) The Reality of Pervasive Transcription. PLoS Biol 9:e1000625.

Clark MB, Mattick JS (2011) Long noncoding RNAs in cell biology. Semin Cell Dev Biol 22:366-376.

Amaral PP*, Clark MB*, Gascoigne DK*, Dinger ME, Mattick JS (2011). lncRNAdb: a reference database for long noncoding RNAs. Nucleic Acids Res. 39: D146-151.

*Joint first authors

Dr Michael Clark



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