Dr Tyani Chan

Group Leader - Autoantibodies

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia

Tyani completed her Bachelor of Medical Science majoring in Immunology at the University of Sydney. She then earned her PhD at the Garvan Institute under the guidance of Prof Robert Brink.

Tyani’s PhD candidature resulted in the development of the first experimental model of acquired autoimmunity. This experimental model allows researchers to study the various ways that our immune system maintains normal health by preventing the emergence of self-attacking antibodies.  It can also be used to study how normal processes break down and potentially lead to autoimmune disease. 

Currently, she holds a Fellowship and Project Grant from the NHMRC and her research interests include autoimmunity and allergic diseases.

Research Interests

Autoimmune Diseases
Allergy
B cells
Antibody Responses

Awards and Honours

2015-2017 - NHMRC New Investigator Project Grant
2013-2016 - NHMRC Early Career Fellowship
2014 - Keystone Symposium Travel Award
2011 - Early Career Researcher Prize, ASI NSW/ACT
2011 - Australasian Society of Immunology (ASI) Travel Award
2010 - International Summer Program Travel Award, RIKEN Research Centre,
2010 - Best Presentation Award, RIKEN Research Center for Allergy and Immunology, Japan
2009 - Postgraduate Research Scheme Scholarship, UNSW Australia
2009 - Keystone Symposium Travel Award
2008 - Flow Cytometry Prize, Advanced Cytometry Facility NSW

Education

2010 - PhD in Medicine, University of New South Wales - Australia
2001 - BMedSc, University of Sydney - Australia

Selected Publications

D. Butt*, T.D. Chan*, K. Bourne, J.R. Hermes, A. Nguyen, A. Statham, LA. O’Reilly, A. Strasser, S.Price, P.Schofield, D.Christ, A.Basten, C.S. Ma, S.G. Tangye, T.G.Phan, V. Koneti Rao and R.Brink. 2015. Rogue Germinal Center B cells: Unconventional lymphocytes released by FAS inactivation that drive IgE and autoantibody production. Immunity. 42:890-902. *Equal first-author contribution.

Chan, T.D., K. Wood, J.R. Hermes, D. Butt, C.J. Jolly, A. Basten, and R. Brink. 2012. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37, 893-904.

Chan, T.D. and R. Brink. 2012. Affinity-based selection in the germinal center. Immunological Reviews 247, 11-23.

Chan, T.D., S. Gardam, D. Gatto, V.M. Turner, J. Silke, and R. Brink. 2010. In vivo control of B-cell survival and antigen-specific B-cell responses. Immunological Reviews 237:90-103.

Chan, T.D., D. Gatto, K. Wood, T. Camidge, A. Basten, and R. Brink. 2009. Antigen affinity controls rapid T-dependent antibody production by driving the expansion rather than the differentiation or extrafollicular migration of early plasmablasts. The Journal of Immunology 183:3139-3149.

R. Brink, D. Paus, K. Bourne, J.R. Hermes, S. Gardam, T.G. Phan, T.D. Chan. 2014. The SWHEL system for high-resolution analysis of in vivo antigen-specific T-dependent B cell responses. Methods in Molecular Biology 1291:103-123. ISBN 978-1-4939-2498-1, © 2015.

Brink, R., T.G. Phan, D. Paus, and T.D. Chan. 2008. Visualizing the effects of antigen affinity on T-dependent B-cell differentiation. Immunology and Cell Biology 86:31-39.

McGuire, H.M.*, Vogelzang, A.*, J. Warren, C. Loetsch, K.D. Natividad, T.D. Chan, R. Brink, M. Batten and C. King. 2015. Interleukin-21 and interleukin-4 collaborate to shape T dependent antibody responses. Journal of Immunology 195:5123-5135.

Sabouri, Z., P. Schofield, K. Horikawa, E. Spierings, D. Kipling, K.L. Randall, D. Langley, B. Roome, R. Vazquez-Lombardi, R. Rouet, J. Hermes, T.D. Chan, R. Brink, D.K. Dunn-Walters, D. Christ, and C.C. Goodnow. 2014. Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. PNAS. 111:E2567-2575.

Lee, S.K., R.J. Rigby, D. Zotos, L.M. Tsai, S. Kawamoto, J.L. Marshall, R.R. Ramiscal, T.D. Chan, D. Gatto, R. Brink, D. Yu, S. Fagarasan, D.M. Tarlinton, A.F. Cunningham, and C.G. Vinuesa. 2011. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J Exp Med. 208:1377-1388.

Avery, D.T., E.K. Deenick, C.S. Ma, S. Suryani, N. Simpson, G.Y. Chew, T.D. Chan, U. Palendira, J. Bustamante, S. Boisson-Dupuis, S. Choo, K.E. Bleasel, J. Peake, C. King, M.A. French, D. Engelhard, S. Al-Hajjar, S. Al-Muhsen, K. Magdorf, J. Roesler, P.D. Arkwright, P. Hissaria, D.S. Riminton, M. Wong, R. Brink, D.A. Fulcher, J.L. Casanova, M.C. Cook, and S.G. Tangye. 2010. B cell-intrinsic signaling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 207:155-171.

Randall, K.L., T. Lambe, A.L. Johnson, B. Treanor, E. Kucharska, H. Domaschenz, B. Whittle, L.E. Tze, A. Enders, T.L. Crockford, T. Bouriez-Jones, D. Alston, J.G. Cyster, M.J. Lenardo, F. Mackay, E.K. Deenick, S.G. Tangye, T.D. Chan, T. Camidge, R. Brink, C.G. Vinuesa, F.D. Batista, R.J. Cornall, and C.C. Goodnow. 2009. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol 10:1283-1291.

Phan, T.G., D. Paus, T.D. Chan, M.L. Turner, S.L. Nutt, A. Basten, and R. Brink. 2006. High affinity germinal center B cells are actively selected into the plasma cell compartment. J Exp Med 203:2419-2424.

Paus, D., T.G. Phan, T.D. Chan, S. Gardam, A. Basten, and R. Brink. 2006. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J Exp Med 203:1081-1091.

Grech, A.P., S. Gardam, T. Chan, R. Quinn, R. Gonzales, A. Basten, and R. Brink. 2005. Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site. J Biol Chem 280:31572-31581.

Grech, A.P., M. Amesbury, T. Chan, S. Gardam, A. Basten, and R. Brink. 2004. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity 21:629-642.

Dr Tyani Chan