Diabetes and Transcription Factors
The causes of diabetes and obesity are only partially understood. These conditions are epidemic in Australia, and treatments are only partially effective.
In diabetes, we know there are changes in gene expression in beta-cells that can yield clues about what is going wrong. Through the use of a variety of tissue-specific knockout and transgenic mice we work with transcription factors to identify mechanisms of beta-cell failure as well as ways to improve beta-cell function, which may lead to improved treatments of human diabetes.
Obesity is the result of a long-term imbalance between energy intake and expenditure. We are working with a transcription factor which when activated prevents excessive weight gain. This may lead to novel human therapeutic agents.
Liver diseases including fatty liver, hepatic fibrosis and cirrhosis are increasingly common in today’s society. They are increased by diabetes, and obesity, indicating fascinating interactions. We are studying the role of various transcription factors in liver diseases
In the News
Improving life for those who suffer most from Type 1 diabetes - Jun 19, 2012
Test Vitamin D levels in pregnant women say researchers - Apr 04, 2011
How fatness gets forecast in the womb - Jan 28, 2011
Garvan Scientists acknowledged on World Diabetes Day - Nov 14, 2010
A potential new treatment for Type 2 diabetes - May 06, 2010
Regulating the sugar factory in diabetes - May 19, 2009
Garvan scientist wins L’Oréal For Women In Science Fellowship - Sep 26, 2007