Prof Stuart Tangye

Lab Head - Immunology and Immunodeficiency

Principal Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Professor, St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia

Professor Stuart Tangye completed his PhD on B-cell leukemia under the supervision of Prof Bob Raison at the University of Technology Sydney in 1995 and then undertook postdoctoral training at the DNAX Research Institute for Molecular and Cellular Biology (Palo Alto California, USA; 1996-1999) in the laboratories of Drs Jan de Vries, Joe Phillips and Lewis Lanier.

It was during this time that his passion for human immunology, cell biology and immune deficiencies was ignited. He returned to Australia in 2000 as a University of Sydney Research Fellow to work with Dr Phil Hodgkin at the Centenary Institute of Cancer Medicine and Cell Biology (University of Sydney). He established his own independent research lab in 2002, and was recruited to the Garvan Institute in 2006.

Since 1995, he has published >100 peer-reviewed research articles and invited reviews. In 2011, he received the Gottschalk Medal from the Australian Academy of Sciences, which recognises “outstanding research in the medical sciences by scientists no more than 40 years of age”. In addition to overseeing his own research lab, he serves as the Deputy Editor of the journal Immunology & Cell Biology, as an Associate Editor of Journal of Immunology, and an Advisory Editor for the Journal of Experimental Medicine.

He is regularly invited to present his latest findings at numerous international immunology conferences. The Tangye lab has been supported by Research Fellowships and Program and Project grants awarded by the NHMRC, Cancer Council NSW, Association for International Cancer Research (UK), XLP Research Trust (UK) and the Cancer Institute NSW.

Research Interests

Human immunology and immunodeficiency
Transcriptional regulation of lymphocyte function
Cytokine biology
Pathogenesis of human immunological diseases
Infectious susceptibility in human primary immunodeficiencies

In the News

Unravelling the complexity of human immune disease gene by gene: clues from genetic immunodeficiencies - Aug 26, 2016
Inter-disciplinary approach to medical research changing the way we think about cancer treatment - Jun 21, 2016
Antibodies on the agenda: major funding boost for Garvan immunologists - Mar 18, 2016
A piece in the puzzle of primary immunodeficiency - Aug 07, 2015
Insight into how we protect ourselves from certain bacteria and fungi - May 04, 2015
Associate Professor Stuart Tangye awarded a Fulbright scholarship - Feb 16, 2015
Molecular interplay explains many immunodeficiencies - Nov 11, 2013
Understanding immune system memory – in a roundabout way - Nov 11, 2013
Garvan receives $15.5 million in NHMRC funding round - Oct 25, 2013
Surprise finding reveals adaptive nature of immune system - Jul 15, 2013
Garvan performs well in NHMRC grants round - Oct 24, 2012
Potential gene therapy for patients with rare disease - Apr 11, 2012
Potential to adjust the volume control on our immune response - Mar 16, 2012
Understanding kiss of death for some improves outlook for others - Nov 02, 2011
Stuart Tangye wins 2011 Gottschalk Medal - Dec 15, 2010
Creating clarity around a key aspect of the immune system - Aug 16, 2010
How a single molecule gives our immune systems their memory - Jan 11, 2010
What B cells can tell us about certain cancers and autoimmune diseases - Nov 23, 2009
Finding that could shed light on "golden staph", candida and allergies - Jul 01, 2008
Silencing of molecular 'conversation' may help curb severe allergies - Mar 07, 2008
Managing the way our immune system remembers infection - Jul 31, 2007

Awards and Honours

2015 - Fulbright Senior Scholarship - Australian-USA Fulbright Commission
2013 - UTS Alumni Award for Excellence – Faculty of Science
2013-2017 - Principal Research Fellowship, National Health and Medical Research Council of Australia
2011 - Gottschalk Medal, Australian Academy of Science
2008-2012 - Senior Research Fellowship, National Health and Medical Research Council of Australia
2006 - Young Tall Poppy, Office of Science and Medical Research
2004-2007 - RD Wright Career Development Fellowship (Biomedical), National Health and Medical Research Council of Australia
1992 - University Medal, University of Technology


1996 - PhD, University of Technology Sydney - Australia
1992 - B App Sci (Biomedical); Hons First Class and the University Medal, University of Technology Sydney - Australia

Selected Publications

S Pelham, H Lenthall, EK Deenick, SG Tangye. Elucidating the effects of disease-1 causing mutations on STAT3 function in autosomal dominant hyper-IgE syndrome. J Allergy Clin Immunol (October 2016) 138:1210-1213

C Ma, SG Tangye. Immunology: Cytotoxic T cells that escape exhaustion.  Nature (September 2016) 537: 312-314

HG Woon, A Braun, JJ Li, C Smith, J Edwards, F Sierro, CG Feng, R Khanna, A Bell, FR Carbone, SG Tangye, AB Rickinson, T Gebhardt, WJ Britton, UI Palendira. IL-15 and TGF-b potentiate the selective retention and strategic positioning of Epstein-Barr virus-specific resident memory CD8+ T cells within human lymphoid tissues. PLoS Pathog (August 2016) 10:1371

J Jurczyluk, MA Munoz, OP Skinner, RC Chai, N Ali, U Palendira, JM Quinn, A Preston, SG Tangye, AJ Brown, E Argent,  JB Ziegler, S Mehr, MJ Rogers. Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases. Immun Cell Biology (July 2016) 10.1038

CS Ma, N Wong, G Rao, DT Avery, J Torpy, P O’Young, EK Deenick, J Bustamante, S Boisson-Dupuis, A Puel, S Okada, M Kobayashi, M Elliott, S Sebnem Kilic, J El Baghdadi, Y Minegishi, A Bousfiha, P Hsu, DE Campbell, MO Stormon, M Wong, S Adelstein, DA Fulcher, MC Cook, P Stepensky, K Boztug, R Beier, A Ikincioğullari, JB Ziegler, P Gray, C Picard, B Grimbacher, K Warnatz, SM Holland, G Uzel, JL Casanova, SG Tangye.  Unique and shared signaling pathways co-operate to regulate the differentiation of human CD4+ T cells into distinct effector subsets. J Exp Med (July 2016) 10.1084

V Bryant, SG Tangye. The Expanding Spectrum of NFkB1 Deficiency. J Clin Immunol (June 2016) 36:531-532 

L Moens, A Kane, SG Tangye. Naïve and memory B cells exhibit distinct biochemical responses following BCR engagement. Immunol Cell Biol (EPub 22 April 2016)

A Kane, A Lau, R Brink, SG Tangye, EK Deenick. STAT3 is a critical B-cell intrinsic regulator of functional antibody responses and IgE production. J Allergy Clin Immunol (accepted May 2016)

PE Gray, TA O’Brien, R Sutton, M Wagle, U Palendira, T Roscioli, SG Tangye, JB Ziegler, K Frith. Cerebral vasculitis in X-linked Lymphoproliferative Disease cured by matched unrelated cord blood transplant.  J Clin Immunol (October 2015) 35: 604-609

AY  Kreins, MJ Ciancanelli, S Okada,  XF Kong, N Ramírez-Alejo, S Sebnem Kilic, J El Baghdadi, S Nonoyama, S Alireza Mahdaviani, F Ailal,  A Bousfiha, D Mansouri, E Nievas, C Ma, G Rao, A Bernasconi, HS Kuehn,  J Niemela, J Stoddard, P Deveau, A Cobat, S El Azbaoui, A Sabri, CK Lim, M Sundin, DT Avery,  R Halwani, AV Grant, B Boisson, D Bogunovic, Y Itan, M Moncada-Velez, R Martinez-Barricarte, M Migaud, C Deswarte, L Alsina,  D Kotlarz, C Klein, I Muller-Fleckenstein, B Fleckenstein, V Cormier-Daire, S Rose-John, C Picard,  L Hammarstrom, A Puel, S Al-Muhsen, L Abel, D Chaussabel, SD Rosenzweig, Y Minegishi, SG Tangye, J Bustamante, JL Casanova, S Boisson-Dupuis. 2015. Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome. J Exp Med (EPub 24 August 2015) 

SG Tangye, R Brink, CC Goodnow. TG Phan. 2015. Snapshot: Interactions between B cells and T cells. Cell  (in press 13 August 2015) 162:926

RP Wilson, ML Ives, G Rao, A Lau, K Payne, M Kobayashi, PD Arkwright, J Peake, M Wong, S Adelstein, JM Smart, MA French, DA Fulcher, C Picard, J Bustamante, SBoisson-Dupuis, P Gray, P Stepensky, K Warnatz, AF Freeman, J Rossjohn, J McCluskey, SM Holland, JL Casanova, G Uze,  C Ma, SG Tangye, EK Deenick. 2015. STAT3 is a critical cell intrinsic regulator of human unconventional T cell numbers and function. J Exp Med 2015; 212: 855-864

C Ma, N Wong, G Rao, D Avery, J Torpy, J Bustamante, J Okada, J Stoddard, EK Deenick, S Pelham, S Boisson-Dupuis, A Puel, M Kobayashi, P Arkwright, SS Kilic, J El Baghdadi, S Nonoyama, Y Minegishi, SA Mahdaviani, D Mansouri, A Bousfiha, M French, P Hsu, D Campbell, M Stormon, M Wong, S Adelstein, J Smart, D Fulcher, M Cook, TG Phan, P Stepensky, K Boztug, A Ikincioğullari, R Beier, J Ziegler, P Gray, C Picard, B Grimbacher, K Warnatz, S Holland, JL Casanova, G Uzel, SG Tangye. 2015. Monogenic mutations differentially impact the quantity and quality of T follicular helper cells inhuman primary immunodeficiencies. J Allergy Clin Immunol (Published online July 8th 2015).

S Okada, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson L, Marzouqa H, Shamma J, Gonzalez M, Martinez-Baricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Lindestam Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay J-P, Moshous D, Hambleton S, Latour S, Arkwright P, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL. Impairment of IL-17 immunity to Candida and IFN-g immunity to Mycobacterium in humans with inherited RORgT deficiency. Science (published online 10th July 2015)

SG Tangye. 2015. Advances is IL-21 biology enchancing our understanding of human disease. Curr Opin Immunol (April 2015). 34: 107-115

SG Tangye. 2014. T cells require DOCK8 for flexibility and function. J Exp Med (December 2014).  211: 2482-2483

CS Ma  & SG Tangye. 2014. Human T follicular helper cells in primary immunodeficiencies. Curr Opin Pediatr (November 2014). 26: 720-726

SG Tangye. 2014. XLP: Clinical Features and Molecular Etiology due to Mutations in SH2D1A Encoding SAP. J Clin Immunol (September 2014). 34: 772-779

SG Tangye. 2014 The right "Job" for STAT3 mutant mice! Blood (May 2014) 123: 2907-2909

L Moens  & SG Tangye. 2014. Cytokine-mediated regulation of plasma cell generation: IL-21 takes centre stage. Frontiers in Immunology (February 2014) 5: 1-13

EK Deenick, DT Avery, A Chan, LJ Berglund, ML Ives, L Moens, JL Stoddard, J Bustamante, S Boisson-Dupuis, M Tsumura, M Kobayashi, PD Arkwright, D Averbuch, D Engelhard, K Magdorf, J Roesler, J Peake, M Wong, S Adelstein, S Choo, JM Smart, MA French, DA Fulcher, MC Cook, C Picard, A Durandy, C Klein, SM Holland,G Uzel, JL Casanova, CS Ma, SG Tangye. 2013. Naïve and memory human B cells have distinct requirements for STAT3 activation to differentiate into antibody-secreting plasma cells. J Exp Med (online November 2013). 210: 2739-2753

LJ Berglund, DT Avery, CS Ma, L Moens, EK Deenick, J Bustamante, S Boisson-Dupuis, M Wong, S Adelstein, PD Arkwright, R Bacchetta, L Bezrodnik, H Dadi, C Roifman, DA Fulcher, JB Ziegler, JM Smart, M Kobayashi, C Picard, A Durandy, MC Cook, JL Casanova, G Uzel,SG Tangye. IL-21 signalling via STAT3 primes human naïve B cells to respond to IL-2 to enhance their differentiation into plasmablasts. BLOOD (online October 25th 2013). 122: 3940-3950

ML Ives, CS Ma, U Palendira, A Chan, J Bustamante, S Boisson-Dupuis, PD Arkwright, D Engelhardt, D Averbuch K Magdorf, J Roesler,  J Peake, M Wong, S Adelstein, S Choo, JM Smart, MA French, DA Fulcher, MC Cook, M Tsumura, M Kobayashi, G Uzel, JL Casanova, SG Tangye*, EK Deenick* (*equal contribution). 2013. STAT3 mutations underlying autosomal dominant hyper-IgE syndrome impair human CD8+ T cell memory formation and acquisition of cytotoxic machinery. J Allergy Clin Immunol 132: 400-411.e9.

SG Tangye, CS Ma, R Brink, EK Deenick. 2013. The good, the bad and the ugly - Tfh cells in human health and disease. Nat Rev Immunol 13: 412-426.

CS Ma, DT Avery, A Chan, M Batten, J Bustamante, S Boisson-Dupuis, PD Arkwright, AY Kreins, D Averbuch, D Engelhardt, J Roesler, K Magdorf, SS Kilic, Y Minegishi, S Nonoyama, MA French, S Choo, JM Smart, J Peake, M Wong, P Gray, MC Cook, DA Fulcher, JL Casanova, EK Deenick, SG Tangye. 2012. Functional STAT3 deficiency compromises the generation of human T follicular helper cells. BLOOD. 119: 3997-4008.

U Palendira, C Low, AI Bell, CS Ma, RJ Abbott, TG Phan, DS Riminton, S Choo, JM Smart, V Lougaris, S Giliani, RH Buckley, B Grimbacher, F Alvaro, A Klion, KE Nichols, S Adelstein, AB Rickinson, SG Tangye. Expansion of somatically reverted memory CD8+ T cells in X-linked lymphoproliferative disease is due to selective pressure from Epstein Barr virus. J Exp Med. 209: 913-924

KL Randall*, SS-Y Chan*, CS Ma*, I Fung*, Y Mei, M Yabas, A Tan, PD Arkwright, W Al Suwairi, S Oswaldo Lugo Reyes, MA Yamazaki-Nakashimada, M de la Luz Garcia-Cruz, JM Smart, C Picard, S Okada, E Jouanguy, J-L Casanova, RJ Cornall, S Russell, J Oliaro*, SG Tangye*, EM Bertram*, CC Goodnow* (*equal contribution). 2011. DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med 208: 2305-2320.

U Palendira, C Low, A Chan, AD Hislop, E Ho, TG Phan, EK Deenick, MC Cook, DS Riminton, S Choo, R Loh, C Booth, HB Gaspar, A Moretta, R Khanna, AB Rickinson, SG Tangye. Molecular pathogenesis of EBV infection as revealed by analysis of XLP carriers with heterozygous expression of SAP. PLoS Biol 9: e1001187.

M Recher*, LJ Berglund*, DT Avery, MJ Cowan, AR Gennery, J Smart, J Peake, M Wong, S-Yun Pai, S Baxi, JE Walter, U Palendira, GA Tangye, M Rice, S Brothers, W Al-Herz, H Oettgen, H Eibel, JM Puck, F Cattaneo, JB Ziegler, S Giliani, SG Tangye*, LD Notarangelo* (*equal contribution). 2011. IL-21 is the primary common gamma chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 118: 6824-6835.

EK Deenick, A Chan, CS Ma, D Gatto, PL Schwartzberg, R Brink*, SG Tangye* (*equal contribution). 2010. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 33: 241-253

DT Avery, EK Deenick, CS Ma, S Suryani, N Simpson, GY Chew, TD Chan, U Palendira, J Bustamante, S Boisson-Dupuis, S Choo, KE Bleasel, J Peake, C King, MA French, D Engelhard, S Al-Hajjar, S Al-Muhsen, K Magdorf, J Roesler, PD Arkwright, P Hissaria, DS Riminton, M Wong, R Brink, DA Fulcher, J-L Casanova, MC Cook, and SG Tangye. 2010. B-cell intrinsic signalling through IL-21 receptor and STAT3 is required for establishing long-lived antibody responses in humans. J Exp Med 207: 155-171

CS Ma, S Suryani, DT Avery, A Chan, R Nanan, B Nanan, EK Deenick, SG Tangye. 2009. Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL-12. Immunol Cell Biol. 87: 590-600

CS Ma, GYJ Chew, N Simpson, A Priyadarshi, M Wong, B Grimbacher, DA Fulcher, SG Tangye*, MC Cook* (equal contribution). 2008. Hyper IgE syndrome due to mutations in STAT3 represents a Th17 deficiency. J Exp Med 205: 1551-1557

DT Avery, VL Bryant, CS Ma, R de Waal Malefyt, and SG Tangye. 2008. IL-21-induced isotype switching to IgG and IgA by human naïve B cells is differentially regulated by IL-4. J Immunol 181: 1767-1779

VL Bryant, CS Ma, DT Avery, Y Li, KL Good, LM Corcoran, R de Waal Malefyt and SG Tangye. 2007. Cytokine-mediated regulation of human B-cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 179: 8180-8190

Prof Stuart Tangye