Prof Herbert Herzog

Lab Head - Eating Disorders

Senior Principal Research Fellow

Conjoint/Adjunct Role(s)

Conjoint Professor, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

Since completing my PhD studies in 1989 the achievements of my research have been recognised by awards of the prestigious Erwin Schrödinger Postdoctoral Fellowship (1991), my Habilitation at the Free University in Berlin (1996), the award of a Wellcome Trust Fellowship (1999), the appointment to NHMRC Senior Research Fellow in 2002 and promotion to NHMRC Principal Research Fellow in 2007 and 2011 and my appointment as Director of the Neuroscience Program at the Garvan Institute of Medical Research in 2005. Over the years I have developed and established myself as a world leader in obesity research with a special focus on neuropeptides that control energy homeostasis centrally as well as peripherally.

My achievements have been recognised through invitations to present keynote and plenary lectures at numerous national and international conferences as well as invitations to present at seminar series of different national and international organisations including industry. I have received the ‘Victor Mutt Award” from the International Regulatory Peptide Society in 2009 and was invited to give the ANS plenary lecture in 2010, the highest reward given by the society.

My commitment is to undertake high-quality research in the neurobiology area with a specific focus on determining the fundamental processes that can lead to the development of type 2 diabetes, obesity or the other extreme anorexia, to translate this into potential health outcomes for affected individuals with these conditions. To do this I am continuously developing novel sophisticated transgenic and knockout mouse models and investigate them with an integrated physiology approach and also link this to human studies. I am also interested in how homeostatic processes that regulate bodyweight are coordinated with other homeostatic processes in the body, like the one that control bone mass. I am a great believer in collaborative approaches combining the expertise from different research areas ranging from basic science to clinical studies to maximise the increase in knowledge on complex systems.

Currently I am actively involved in four national and eight international research collaborations. The later ones have attracted a considerable amount of funding from international granting bodies including the Human Frontiers Science Program, Wellcome Trust and the Japanese Government.

Research Interests

NPY and the role of other family members like PYY and pancreatic poly peptide.
Appetite control
Energy homeostasis
Eating disorders
Obesity
Stress
Depression

Awards and Honours

NHMRC Principal Research Fellow
Victor Mutt Award (International Society for Regulatory Peptides)
Barbara Ell Seminar Series Lecturer
Erwin Schrodinger Fellowship

Education

2005 - Leadership Development Program, Melbourne Business School - Australia
1996 - Doctor of Science, Free University of Berlin - Germany
1989 - PhD, University of Innsbruck - Austria
1986 - BSc, University of Innsbruck - Austria

Selected Publications

Baldock, P.A., Sainsbury, A., Couzens, M., Enriquez, R.F., Gardiner, E.M., Herzog, H. (2002) Hypothalamic Y2 receptors regulate bone formation. J. Clin. Invest. 109, 915-921.

Sainsbury, A., Schwarzer, C. Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J., Herzog, H. (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev. 16, 1077-1088.

Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Fürtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hökfelt, T., Herzog, H. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA (Track II). 99, 8938-8943.

Batterham, R., Cowley, M., Small, C., Herzog, H., Cohen, M., Dakin, C., Wren, A., Brynes, A., Low, M., Ghatei, M., Cone, R., Bloom, S. (2002) Gut hormone, PYY3-36 physiologically inhibits food intake. Nature.  418, 650-654.

Sainsbury, A., Schwarzer, C., Couzens, M., Herzog, H. (2002) Y2 receptor deletion attenuates the diabetic syndrome of genetically obese ob/ob mice. Diabetes. 51(12), 3420-3427.

Karl, T., Schwarzer, C., Lin, S., Sainsbury, A., Boey, D. Couzens, M., von Hörsten,S., Herzog, H. (2004) Y1 receptors regulate aggressive behavior by modulating sertonin pathways. Proc. Natl. Acad. Sci. USA (Track II). 101, 12742-12747.

Wheway, J., Mackay, C.R., Newton, R., Sainsbury-Salis, A., Boey, D., Mackay, F.* & Herzog, H.* (2005) A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J. Exp. Med. 202(11), 1527-38. *equal last authors

Sainsbury, A., Bergen, H.T., Boey, D., Bamming, D., Cooney, G., Lin, S., Couzens, M., Stroth, N., Lee, N.J., Herzog, H. (2006) Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Diabetes. 55(1), 19-26.

Batterham, R.L., Chivers, J.E., Kapoor, S., Heffron, H., Le Roux, C.W., Thomas, L., Bell, J.D., Herzog, H., Withers, D.J. (2006) Critical role for peptide YY in protein-mediated satiation and body weight regulation. Cell Metabolism. 4(3), 223-233.

Kuo, L.E., Kitlinska, J.B., Tilan, J.U., Li, L., Baker, S.B., Johnson, M.D., Lee, E.W., Burnett, M.S., Fricke, S.T., Kvetnansky, R.K., Herzog, H., Zukowska, Z. (2007) Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med. 13(7), 803-11.

Johnen, H., Lin, S., Kuffner, T., Brown, D.A., Tsai, V.W.W., Bauskin, A.R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., Hunter, M., Fairlie, W.D., Lee, N.J., Enriquez, R.F., Baldock, P.A., Corey, E., Apple, F.S., Murakami, M.M., Lin, E.J., Wang, C., During, M.J., Sainsbury, A., Breit, S.N.* & Herzog, H.* (2007) Tumour-induced anorexia and weight loss are mediated by the TGF-b superfamily cytokine MIC-1. Nat. Med. 13(11), 1333-1340. *equal last authors

Cox, H.M., Iain, R., Tough, R.I., Woolston, A.M., Zhang, L., Nguyen, A.D., Sainsbury, A. Herzog H(2010) Peptide YY is critical for Gpr119-induced activation of gastrointestinal mucosal responses.  Cell Metabolism. 11(6), 532-542.

Macia, L., Yulyaningsigh, E., Pangon, L., Nguyen, A.D., Lin, S., Shi, YC., Zhang, L., Bijker, M., Grey, S., Mackay, F., Sainsbury, A., Herzog, H. (2012) Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity. Diabetes. 61(12), 3228-3238.

Shi, Y-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X-F., Baldock, P., Ernriquez, R., Zhang, L. Sainsbury, A., Herzog, H.*, Lin, S*. (2013) Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism. 17(2), 236-48. *equal last authors

Zhang, L., Lee, I-C.J, Enriquez, R.F., Lau, J., Vähätalo, L.H., Baldock, P.A., Savontaus, E., Herzog, H. (2014) Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons. Molecular Metabolism. 3(5), 581-591.

Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B.A., Enriquez, R., Driessler, F., Macia, L., Khor, E.C., Qi, Y., Baldock, P., Sainsbury, A., Herzog, H. (2014) Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism. 19(1), 58-72.

Lee, N.J., Nguyen, A.D., Enriquez, R.F., Luzuriaga, J., Bensellam, M., Rogers, M., Laybutt, D.R., Baldock, P.A., Herzog, H. (2015) NPY signalling in osteoblasts controls glucose homeostasis. Molecular Metabolism. 4(3), 164-174.

Shi, Y.C., Loh, K., Bensellam, M., Zhai, L., Lee, K., Lau, K., Cantley, K.J., Laybutt, D.R., & Herzog, H. (2015) Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in mice. Endocrinology, 156(9):3122-36. (Cover)


Prof Herbert Herzog