Prof Herbert Herzog
Senior Principal Research Fellow
Since completing my PhD studies in 1989 the achievements of my research have been recognised by awards of the prestigious Erwin Schrödinger Postdoctoral Fellowship (1991), my Habilitation at the Free University in Berlin (1996), the award of a Wellcome Trust Fellowship (1999), the appointment to NHMRC Senior Research Fellow in 2002 and promotion to NHMRC Principal Research Fellow in 2007 and 2011 and my appointment as Director of the Neuroscience Program at the Garvan Institute of Medical Research in 2005. Over the years I have developed and established myself as a world leader in obesity research with a special focus on neuropeptides that control energy homeostasis centrally as well as peripherally.
My achievements have been recognised through invitations to present keynote and plenary lectures at numerous national and international conferences as well as invitations to present at seminar series of different national and international organisations including industry. I have received the ‘Victor Mutt Award” from the International Regulatory Peptide Society in 2009 and was invited to give the ANS plenary lecture in 2010, the highest reward given by the society.
My commitment is to undertake high-quality research in the neurobiology area with a specific focus on determining the fundamental processes that can lead to the development of type 2 diabetes, obesity or the other extreme anorexia, to translate this into potential health outcomes for affected individuals with these conditions. To do this I am continuously developing novel sophisticated transgenic and knockout mouse models and investigate them with an integrated physiology approach and also link this to human studies. I am also interested in how homeostatic processes that regulate bodyweight are coordinated with other homeostatic processes in the body, like the one that control bone mass. I am a great believer in collaborative approaches combining the expertise from different research areas ranging from basic science to clinical studies to maximise the increase in knowledge on complex systems.
Currently I am actively involved in four national and eight international research collaborations. The later ones have attracted a considerable amount of funding from international granting bodies including the Human Frontiers Science Program, Wellcome Trust and the Japanese Government.
In the NewsTaking a ‘diet holiday’ could improve weight loss - Jan 20, 2016
NHMRC funding success for Garvan researchers - Nov 09, 2015
Jackie Lau and Louise Cottle win 2014 Stuart Furler Travel Awards - Nov 06, 2014
Garvan Institute scientists receive $10.7 million in NHMRC funding - Oct 22, 2014
How fat might be controlled through the body clock - Jan 08, 2014
Garvan receives $15.5 million in NHMRC funding round - Oct 25, 2013
Amy Nguyen wins People's Choice Award in speaking event - Aug 07, 2013
Double-barreled attack on obesity in no way a no-brainer - Jul 10, 2013
The brain circuit that makes it hard for obese people to lose weight - Feb 06, 2013
Garvan performs well in NHMRC grants round - Oct 24, 2012
A powerful gut hormone that affects insulin and blood sugar levels - Jun 16, 2010
New weight loss approach targets the body and not the brain - Nov 25, 2009
Professor Herbert Herzog wins prestigious award - Jan 15, 2009
Low levels of PYY hormone a very early indicator of Type 2 diabetes - Mar 11, 2008
Natural gut hormones may provide a treatment for obesity - Jan 09, 2008
The molecule that can switch appetite off and on - Nov 05, 2007
How we can stop stress from making us obese - Jul 10, 2007
Awards and Honours
Victor Mutt Award (International Society for Regulatory Peptides)
Barbara Ell Seminar Series Lecturer
Erwin Schrodinger Fellowship
1996 - Doctor of Science, Free University of Berlin - Germany
1989 - PhD, University of Innsbruck - Austria
1986 - BSc, University of Innsbruck - Austria
Baldock, P.A., Sainsbury, A., Couzens, M., Enriquez, R.F., Gardiner, E.M., Herzog, H. (2002) Hypothalamic Y2 receptors regulate bone formation. J. Clin. Invest. 109, 915-921.
Sainsbury, A., Schwarzer, C. Couzens, M., Jenkins, A., Oakes, S.R., Ormandy, C.J., Herzog, H. (2002) Y4 receptor knockout rescues fertility in ob/ob mice. Genes Dev. 16, 1077-1088.
Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Fürtinger, S., Jenkins, A., Cox, H.M., Sperk, G., Hökfelt, T., Herzog, H. (2002) Important role of hypothalamic Y2 receptors in body weight regulation revealed in conditional knockout mice. Proc. Natl. Acad. Sci. USA (Track II). 99, 8938-8943.
Batterham, R., Cowley, M., Small, C., Herzog, H., Cohen, M., Dakin, C., Wren, A., Brynes, A., Low, M., Ghatei, M., Cone, R., Bloom, S. (2002) Gut hormone, PYY3-36 physiologically inhibits food intake. Nature. 418, 650-654.
Sainsbury, A., Schwarzer, C., Couzens, M., Herzog, H. (2002) Y2 receptor deletion attenuates the diabetic syndrome of genetically obese ob/ob mice. Diabetes. 51(12), 3420-3427.
Karl, T., Schwarzer, C., Lin, S., Sainsbury, A., Boey, D. Couzens, M., von Hörsten,S., Herzog, H. (2004) Y1 receptors regulate aggressive behavior by modulating sertonin pathways. Proc. Natl. Acad. Sci. USA (Track II). 101, 12742-12747.
Wheway, J., Mackay, C.R., Newton, R., Sainsbury-Salis, A., Boey, D., Mackay, F.* & Herzog, H.* (2005) A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. J. Exp. Med. 202(11), 1527-38. *equal last authors
Sainsbury, A., Bergen, H.T., Boey, D., Bamming, D., Cooney, G., Lin, S., Couzens, M., Stroth, N., Lee, N.J., Herzog, H. (2006) Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice. Diabetes. 55(1), 19-26.
Batterham, R.L., Chivers, J.E., Kapoor, S., Heffron, H., Le Roux, C.W., Thomas, L., Bell, J.D., Herzog, H., Withers, D.J. (2006) Critical role for peptide YY in protein-mediated satiation and body weight regulation. Cell Metabolism. 4(3), 223-233.
Kuo, L.E., Kitlinska, J.B., Tilan, J.U., Li, L., Baker, S.B., Johnson, M.D., Lee, E.W., Burnett, M.S., Fricke, S.T., Kvetnansky, R.K., Herzog, H., Zukowska, Z. (2007) Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med. 13(7), 803-11.
Johnen, H., Lin, S., Kuffner, T., Brown, D.A., Tsai, V.W.W., Bauskin, A.R., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., Hunter, M., Fairlie, W.D., Lee, N.J., Enriquez, R.F., Baldock, P.A., Corey, E., Apple, F.S., Murakami, M.M., Lin, E.J., Wang, C., During, M.J., Sainsbury, A., Breit, S.N.* & Herzog, H.* (2007) Tumour-induced anorexia and weight loss are mediated by the TGF-b superfamily cytokine MIC-1. Nat. Med. 13(11), 1333-1340. *equal last authors
Cox, H.M., Iain, R., Tough, R.I., Woolston, A.M., Zhang, L., Nguyen, A.D., Sainsbury, A. Herzog H(2010) Peptide YY is critical for Gpr119-induced activation of gastrointestinal mucosal responses. Cell Metabolism. 11(6), 532-542.
Macia, L., Yulyaningsigh, E., Pangon, L., Nguyen, A.D., Lin, S., Shi, YC., Zhang, L., Bijker, M., Grey, S., Mackay, F., Sainsbury, A., Herzog, H. (2012) Neuropeptide Y1 receptor in immune cells regulates inflammation and insulin resistance associated with diet-induced obesity. Diabetes. 61(12), 3228-3238.
Shi, Y-C., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X-F., Baldock, P., Ernriquez, R., Zhang, L. Sainsbury, A., Herzog, H.*, Lin, S*. (2013) Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism. 17(2), 236-48. *equal last authors
Zhang, L., Lee, I-C.J, Enriquez, R.F., Lau, J., Vähätalo, L.H., Baldock, P.A., Savontaus, E., Herzog, H. (2014) Stress- and diet-induced fat gain is controlled by NPY in catecholaminergic neurons. Molecular Metabolism. 3(5), 581-591.
Yulyaningsih, E., Loh, K., Lin, S., Lau, J., Zhang, L., Shi, Y., Berning, B.A., Enriquez, R., Driessler, F., Macia, L., Khor, E.C., Qi, Y., Baldock, P., Sainsbury, A., Herzog, H. (2014) Pancreatic polypeptide controls energy homeostasis via Npy6r signaling in the suprachiasmatic nucleus in mice. Cell Metabolism. 19(1), 58-72.
Lee, N.J., Nguyen, A.D., Enriquez, R.F., Luzuriaga, J., Bensellam, M., Rogers, M., Laybutt, D.R., Baldock, P.A., Herzog, H. (2015) NPY signalling in osteoblasts controls glucose homeostasis. Molecular Metabolism. 4(3), 164-174.
Shi, Y.C., Loh, K., Bensellam, M., Zhai, L., Lee, K., Lau, K., Cantley, K.J., Laybutt, D.R., & Herzog, H. (2015) Pancreatic PYY is critical in the control of insulin secretion and glucose homeostasis in mice. Endocrinology, 156(9):3122-36. (Cover)