Dr Kharen Doyle

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Lecturer, St Vincent’s Clinical School, Faculty of Medicine, UNSW Australia

I completed my PhD at the Queensland University of Technology where I studied the role of Insulin Like Growth Factor-1 following injury in the rat spinal cord. My first post doc position was at the Garvan Institute, where I continued to look at the role of growth factors following nervous system injury.

This project involved the study of olfactory stem cells when neurospheres were discovered to be growing in the neuronal cultures. To this day I continue to isolate and propagate olfactory (neural) stem cells from the olfactory neuroepithelium for use in neurogenic studies.

The olfactory neuroepithelium is used as a model of neurogenesis to allow a greater understanding of how neurons are born in other regions of the nervous system such as the brain. The olfactory neurons are capable of growing into different kinds of neurons including those that degenerate in diseases such as Parkinson’s and Alzheimer’s Disease.

Research Interests

Neural stem cells
Neurogenesis
Olfaction
Neuropeptide Y

Awards and Honours

2000 - Garnett Passe and Rodney Williams Memorial Postdoctoral Fellowship
1994 - Australian Postgraduate Award

Education

2000 - PhD, Queensland University of Technology - Australia
1990 - BSc Hons, University of Queensland - Australia

Selected Publications

Cunha, C., Hort, Y., Shine, J. and K.L.Doyle (2012). Morphological and behavioural changes occur following the X-ray irradiation of the adult mouse olfactory neuroepithelium. BMC Neuroscience, 13,134-147

Doyle, K.L., Hort, Y., Shine, J. and H. Herzog (2012). Neuropeptide Y and Peptide YY have distinct roles in adult olfactory neurogenesis. J Neurosci Res., 90,1126-1135

Lee, N.J., Nguyen,A., Enriquez,R.F., Doyle, K.L., Sainsbury, A., Baldock, P.A. and H. Herzog (2010). Osteoblast specific Y1 receptor deletion enhances bone mass. Bone, 48,461-467 

Lee, N.J., Doyle, K.L., Sainsbury, A., Enriquez, R.F., Hort, Y.J., Riepler, S.J., Baldock, P.A. and H. Herzog (2010). Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity. Journal of Bone and Mineral Research, 25,1736-1747

Doyle, K.L., Karl, T., Hort, Y., Duffy, L., Shine, J. and H. Herzog (2008). Y1 receptors are critical for the proliferation of adult mouse precursor cells in the olfactory neuroepithelium. J Neurochem, 105,641-652

Doyle, K.L., Kazda, A., Hort, Y., McKay, S. and S. Oleskevich (2007). Differentiation of adult mouse olfactory precursor cells into hair cells in vitro. Stem Cells, 25,621-627

 Howell, O.W., Doyle, K., Goodman, J.H., Scharfman, H.E., Herzog, H., Pringle, A., Beck-Sickinger, A.G. and W.P. Gray (2005). Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. J Neurochem, 93,560-570

Doyle, K.L., Khan, M. and A.M. Cunningham (2001). Expression of the intermediate filament protein nestin by sustentacular cells in mature olfactory neuroepithelium. J Comp Neurol, 437,186-195

Dr Kharen Doyle