Dr Guy Barry

Senior Research Officer

Conjoint/Adjunct Role(s)

Conjoint Senior Lecturer, St Vincent's Clinical School, Faculty of Medicine, UNSW Australia

I completed my undergraduate studies at the University of Cape Town in South Africa before moving to The Scripps Research Institute in San Diego. After a year in Professor Greg Sutcliffe’s laboratory, working on discovering serotonin receptors, I joined a start-up biotechnology company, Neurocrine Biosciences Inc.

Nine years later I moved to Australia where I completed my PhD at The University of Queensland, Brisbane, in the laboratory of Prof David Hume investigating Crohn’s disease. Returning to neuroscience, I started my post-doctoral work in Prof Linda Richards’s laboratory at the Queensland Brain Institute exploring the Nuclear Factor I transcription factors in glial fate determination

I then joined Prof John Mattick’s group at the Institute for Molecular Bioscience and moved down to Sydney and the Garvan Institute to remain in Prof Mattick’s group following his appointment as Garvan's Executive Director. My project here has been to investigate the involvement of non-coding RNA in human brain function. In particular, I have made significant progress in uncovering mechanistic pathways controlled by long non-coding RNAs in both normal and abnormal (e.g. schizophrenia and epilepsy) brain function.

Research Interests

Human brain evolution
Non-coding RNA
Induced pluripotent stem cells
Adaptive evolution
Schizophrenia
Epilepsy

Education

2006 - PhD, University of Queensland - Australia
1991 - BSc, Microbiology, University of Cape Town - South Africa

Selected Publications

Barry G, BriggsJA, VanichkinaDP, PothEM, Beveridge NJ, RatnuVS, Nayler SP, Nones K, Hu J, Bredy TW, NakagawaS, Rigo F, TaftRJ, CairnsMJ, Blackshaw S, Wolvetang EJ, MattickJS. (2014) The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molecular Psychiatry 19(4): 486-94

Barry G (2014) Integrating the roles of long and small non-coding RNA in brain function and disease. Molecular Psychiatry 19(4): 410-6

Avesson L, Barry G. (2014) The emerging role of RNA and DNA editing in cancer. Biochim Biophys Acta.  1845(2): 308-316

Piper M *, Barry G *, Harvey TJ, McLeay R, Smith AG, Harris L, Mason S, Stringer BW, Day BW, Wray NR, Gronostajski RM, Bailey TL, Boyd AW, and Richards LJ. (2014) NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development. Journal of Neuroscience 34(8): 2921-30. *Co-first authors

Heng YH, McLeay RC, Harvey TJ, Smith AG, Barry G, Cato K, Plachez C, Little E, Mason S, Dixon C, Gronostajski RM, Bailey TL, Richards LJ, Piper M. (2014) NFIX Regulates Neural Progenitor Cell Differentiation During Hippocampal Morphogenesis. Cerebral Cortex 24(1): 261-79.

Barry G (2013) Lamarckian evolution explains human brain evolution and psychiatric disorders. Frontiers in Neuroscience. 7:224.

Barry G, Mattick JS (2012) The role of regulatory RNA in cognitive evolution. Trends in Cognitive Sciences 16(10): 497-503.

Heng YH, Barry G, Richards LJ, Piper M (2012) Nuclear Factor I Genes Regulate Neuronal Migration. Neurosignals 20(3): 159-67

Piper M, Harris L, Barry G, Heng YH, Plachez C, Gronostajski RM, Richards LJ. (2011) Nuclear factor one X regulates the development of multiple cellular populations in the postnatal cerebellum. J Comp Neurol. 519(17): 3532-48

Piper M*, Barry G*, Hawkins J, Mason S, Lindwall C, Little E, Sarkar A, Smith AG, Moldrich RX, Boyle GM, Tole S, Gronostajski RM, Bailey TL, Richards LJ (2010) NFIA controls telencephalic progenitor cell differentiation through repression of the Notch effector Hes1. Journal of Neuroscience 30:9127-39 *Co-first authors

Piper M, Moldrich RX, Lindwall C, Little E, Barry G, Mason S, Sunn N, Kurniawan ND, Gronostajski RM, Richards LJ. (2009) Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice. Neural Development 4; 4(1): 43

Barry G, Piper M, Lindwall C, Moldrich R, Mason S, Little E, Sarkar A, Tole S, Gronostajski RM, Richards LJ (2008) Specific glial populations regulate hippocampal morphogenesis. Journal of Neuroscience 28:12328-40.

Barry G, Ross IL (2008) Neurosteroids and sporadic Alzheimer’s disease. Current Alzheimer Research 5: 267-374

Piper M, Dawson AL, Lindwall C, Barry G, Plachez C, Richards LJ (2007) Emx and Nfi genes regulate cortical development and axon guidance in the telencephalon. Novartis Foundation Symposium 288: 276-81. Review.

Schwarz DA, Barry G, Mackay KB, Manu F, Naeve GS, Vana AM, Verge G, Conlon PJ, Foster AC, Maki RA (2002) Identification of differentially expressed genes induced by transient ischemic stroke. Brain Research. Molecular Brain Research 101:12-22.

Dr Guy Barry