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New insights into the differentiation and function of T follicular helper cells

Abstract

The seminal studies characterizing T follicular helper (T(FH)) cells described a non-polarized CD4(+) T cell population with a unique ability to home to B cell follicles and to induce antibody production by B cells. In the past few years, the study of T(FH) cells has enjoyed a renaissance and there has been a surge of research activity aimed at understanding the function and differentiation of these important cells. This Review focuses on the current progress in T(FH) cell biology and the important questions that remain unanswered. Particular attention is paid to recent studies that support the idea that T(FH) cells are a separate T cell lineage and those that probe the relationship of T(FH) cells to other T helper cell subsets.

Type Journal
ISBN 1474-1741 (Electronic)
Authors King, C.;
Garvan Authors A/Prof Cecile King
Publisher Name NAT REV IMMUNOL
Published Date 2009-01-01 00:00:00
Published Volume 9
Published Issue 11
Published Pages 757-66
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19855402
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10438_10661/09 King nri2644.pdf