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NPY regulation of bone remodelling

Abstract

Neuropeptide Y (NPY), a classic neuronal regulator of energy homeostasis, is now also known to be involved in the control of bone homeostasis. Of the five known Y receptors through which the NPY family of ligands signals, the Y1 and Y2 receptors have so far been implicated in the control of osteoblast activity and thus bone formation. Analysis of brain specific NPY overexpressing and Y receptor knockout models has revealed a powerful anabolic pathway likely involving hypothalamic Y2 receptors and osteoblastic Y1 receptors. Furthering our understanding of the mechanisms underlying the involvement of the NPY system in the control of bone could lead to the development of therapies to improve bone mass in patients with diseases such as osteoporosis.

Type Journal
ISBN 1532-2785 (Electronic)
Authors Lee, N. J.; Herzog, H.;
Garvan Authors Prof Herbert Herzog , Dr Nikki Lee
Publisher Name NEUROPEPTIDES
Published Date 2009-01-01 00:00:00
Published Volume 43
Published Issue 6
Published Pages 457-63
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19748118
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10500_10708/09 Lee Neuro.pdf