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Vitamin D status and parathyroid hormone in a urban population in Vietnam

Abstract

In this cross-sectional study in Vietnam, the prevalence of vitamin D insufficiency was 46% in adult women and 20% in adult men. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued. INTRODUCTION: Vitamin D insufficiency is adversely associated with health outcomes. Vitamin D status in Asian populations is not well documented. This study sought to assess vitamin D status and its relationship to parathyroid hormone in a Vietnamese population. METHODS: This cross-sectional study involved 205 men and 432 women aged 18-87 years, who were randomly sampled from various districts in Ho Chi Minh City (Vietnam) according to a proportional sampling scheme. Serum concentration of 25(OH)D and PTH were measured by the Electrochemiluminescence immunoassay on the Roche Elecsys 10100/201 system (Roche Diagnosis Elecsys). Vitamin D insufficiency was quantified as serum 25(OH)D levels below 30 ng/ml (75 nmol/L). RESULTS: The average age for men and women was 43.8 +/- 18.4 years (mean +/- SD) and 47.7 +/- 17.1 years, respectively. The mean 25(OH)D concentration in men (36.8 +/- 10.2 ng/mL) was significantly higher than in women (30.1 +/- 5.9; P < 0.0001). The prevalence of vitamin D insufficiency in men was 20% (41/205) which was significantly lower than in women (46%, 199/432). Age, height and weight were independent predictors of 25(OH)D concentrations, and the three factors explained 15% and 5% of variance in 25(OH)D in men and women, respectively. There was a linear inverse relationship between serum 25(OH)D and PTH concentrations, but there was no threshold of 25(OH)D at which PTH levels plateaued. CONCLUSIONS: These data show that vitamin D insufficiency is common even in tropical region, and that women had a greater risk of vitamin D insufficiency than men. These data suggest that an elevation in PTH cannot be used as a marker for vitamin D deficiency.

Type Journal
ISBN 1433-2965 (Electronic) 0937-941X (Linking)
Authors Ho-Pham, L. T.; Nguyen, N. D.; Lai, T. Q.; Eisman, J. A.; Nguyen, T. V.:
Garvan Authors Prof John Eisman
Publisher Name OSTEOPOROSIS INT
Published Date 2011-01-01 00:00:00
Published Volume 22
Published Issue 1
Published Pages 241-8
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20414642
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10550_11282/11 HoPham Osteoporosis Int_.pdf