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MicroRNAs in common diseases and potential therapeutic applications

Abstract

1. Evidence gathered in the last few years has revealed microRNAs (miRNAs) fine-tune gene expression and play an instrumental role in various cellular processes including cell growth, differentiation, proliferation and apoptosis. 2. This review summarizes current knowledge of miRNA-pathways in the pathogenesis of cancer, cardiac diseases, neurodegenerative diseases, diabetes, autoimmune/inflammatory diseases and infection. 3. There is a great promise to target miRNAs as a novel approach to treat human diseases. 4. MiRNA-based therapies are being examined in both animal model studies and human clinical trials.

Type Journal
ISBN 0305-1870 (Linking)
Authors Tsai, L. M.; Yu, D.;
Publisher Name CLIN EXP PHARMACOL P
Published Date 2010-01-01 00:00:00
Published Volume 37
Published Issue 1
Published Pages 102-107
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19671070
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10573_10795/09 Tsai CEPP.pdf