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Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel

Abstract

Growth factor receptor-bound protein 14 (Grb14) is an adaptor protein that is involved in receptor tyrosine kinase signalling. In this study, we report that Grb14 interacts with the rod photoreceptor-specific cyclic-nucleotide-gated channel alpha subunit (CNGA1) and decreases its affinity for cyclic guanosine monophosphate. Channel modulation is controlled by direct binding of the Grb14 Ras-associating domain with the carboxy-terminal region of CNGA1. We observed that the channel remains open in Grb14(-/-) mice that are exposed to light, suggesting that Grb14 is a normal physiological modulator of CNG channel function in vivo.

Type Journal
ISBN 1469-3178 (Electronic) 1469-221X (Linking)
Authors Gupta, V.K.; Rajala, A.; Daly, R.J.; Rajala, R.V.S.
Publisher Name EMBO REP
Published Date 2010-11-01 00:00:00
Published Volume 11
Published Issue 11
Published Pages 861-7
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20890309
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10594_11231/10 Gupta Embo_.pdf