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B-cell tolerance: mechanisms and implications

Abstract

Advances in our knowledge of the spectrum of B-cell activities combined with the remarkable clinical efficacy of B-cell inhibitors in autoimmunity and transplantation settings serve to re-emphasise the importance of tolerance to self and foreign antigens in the B-cell repertoire. In particular, new information is emerging about the molecular mechanisms involved in B-cell tolerance induction and identification of B-cell selective defects that contribute to the pathogenesis of autoimmune/inflammatory diseases.

Type Journal
ISBN 1879-0372 (Electronic) 0952-7915 (Linking)
Authors Basten, A.; Silveira, P.A.:
Garvan Authors Prof Antony Basten
Publisher Name CURR OPIN IMMUNOL
Published Date 2010-10-28 00:00:00
Published Volume 22
Published Issue 5
Published Pages 566-74
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20829011
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10646_11187/10 Basten COI_.pdf