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Therapeutic implications of advances in our understanding of transitional B-cell development in humans

Abstract

B-cell development is characterized by the progressive maturation of hematopoietic stem cells through several stages to ultimately give rise to the mature B-cell pool that has been selected for reactivity against non-self antigens. Thus, the mature pool of naive B cells is capable of elicting high-affinity responses following natural infection with pathogens or vaccination and provides the host with protective long-lived humoral immunity. However, perturbations during the processes of B-cell development and differentiation can give rise to a diverse array of immunological diseases including autoimmunity, immunodeficiency and malignancy. While we have a very rich understanding of the processes underlying B-cell development in mice, our knowledge of the corresponding events occurring in human B cells is substantially less robust. Here, we overview the latest findings relating to human B cells in health and disease with a particular emphasis on the transitional stage of B-cell development.

Type Journal
ISBN 1744-666X (Linking)
Authors Suryani, S.; Tangye, S.G.:
Garvan Authors Prof Stuart Tangye
Publisher Name Expert Review of Clinical Immunology
Published Date 2010-09-01 00:00:00
Published Volume 6
Published Issue 5
Published Pages 765-75
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20828285
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10655_11169/10 Suryani ERCI_.pdf