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Cyclin D as a therapeutic target in cancer.

Abstract

Cyclin D1, and to a lesser extent the other D-type cyclins, is frequently deregulated in cancer and is a biomarker of cancer phenotype and disease progression. The ability of these cyclins to activate the cyclin-dependent kinases (CDKs) CDK4 and CDK6 is the most extensively documented mechanism for their oncogenic actions and provides an attractive therapeutic target. Is this an effective means of targeting the cyclin D oncogenes, and how might the patient subgroups that are most likely to benefit be identified?

Type Journal
Authors Musgrove, E.A.; Caldon, C.E.; Barraclough, J.; Stone, A.; Sutherland, R.L.
Garvan Authors Dr Andrew Stone , Dr Liz Caldon
Publisher Name NAT REV CANCER
Published Date 2011-09-01 00:00:00
Published Volume 11
Published Issue 8
Published Pages 558-72
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21734724
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?10994_11570/11 Musgrove nrc3090.pdf